Identification of Novel Rodent-Borne Orthohantaviruses in an Endemic Area of Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka
We reported the genetic evidence of circulating hantaviruses from small mammals captured in a chronic kidney disease of unknown etiology (CKDu) hotspot area of Sri Lanka. The high seroprevalence of anti-hantavirus antibodies against Thailand orthohantavirus (THAIV) has been reported among CKDu patie...
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ftmdpi:oai:mdpi.com:/1999-4915/13/10/1984/ 2023-08-20T04:09:25+02:00 Identification of Novel Rodent-Borne Orthohantaviruses in an Endemic Area of Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka Devinda S. Muthusinghe Kenta Shimizu Sithumini M. W. Lokupathirage Zhouoxing Wei Yomani D. Sarathkumara G. R. Amanda Fonseka Pavani Senarathne Nobuo Koizumi Tomonori Kawakami Akio Koizumi Chaminda Wickramasinghe Hideki Ebihara Keita Matsuno Yoshimi Tsuda Jiro Arikawa Chandika D. Gamage Kumiko Yoshimatsu agris 2021-10-02 application/pdf https://doi.org/10.3390/v13101984 EN eng Multidisciplinary Digital Publishing Institute Animal Viruses https://dx.doi.org/10.3390/v13101984 https://creativecommons.org/licenses/by/4.0/ Viruses; Volume 13; Issue 10; Pages: 1984 hantavirus Mus booduga Thailand orthohantavirus Anjozorobe hantavirus Text 2021 ftmdpi https://doi.org/10.3390/v13101984 2023-08-01T02:52:05Z We reported the genetic evidence of circulating hantaviruses from small mammals captured in a chronic kidney disease of unknown etiology (CKDu) hotspot area of Sri Lanka. The high seroprevalence of anti-hantavirus antibodies against Thailand orthohantavirus (THAIV) has been reported among CKDu patients and rodents in Sri Lankan CKDu hotspots. We captured 116 small mammals from CKDu endemic regions in the Polonnaruwa District of Sri Lanka. Seven animals (five out of 11 Mus booduga and two out of 99 Rattus rattus) were PCR-positive for the hantavirus. A rat-borne sequence was grouped with a THAIV-like Anjozorobe virus. In contrast, Mus-borne sequences belonged to the THAIV lineage, suggesting a novel orthohantavirus species according to the phylogenetic analyses and whole-genome comparisons. Our genetic evidence indicates the presence of two THAIV-related viruses circulating in this CKDu endemic area, suggesting a basis for further investigations to identify the infectious virus in patients with CKDu and the CKDu induction mechanism of these viruses. Text Rattus rattus MDPI Open Access Publishing Viruses 13 10 1984 |
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Open Polar |
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MDPI Open Access Publishing |
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ftmdpi |
language |
English |
topic |
hantavirus Mus booduga Thailand orthohantavirus Anjozorobe hantavirus |
spellingShingle |
hantavirus Mus booduga Thailand orthohantavirus Anjozorobe hantavirus Devinda S. Muthusinghe Kenta Shimizu Sithumini M. W. Lokupathirage Zhouoxing Wei Yomani D. Sarathkumara G. R. Amanda Fonseka Pavani Senarathne Nobuo Koizumi Tomonori Kawakami Akio Koizumi Chaminda Wickramasinghe Hideki Ebihara Keita Matsuno Yoshimi Tsuda Jiro Arikawa Chandika D. Gamage Kumiko Yoshimatsu Identification of Novel Rodent-Borne Orthohantaviruses in an Endemic Area of Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka |
topic_facet |
hantavirus Mus booduga Thailand orthohantavirus Anjozorobe hantavirus |
description |
We reported the genetic evidence of circulating hantaviruses from small mammals captured in a chronic kidney disease of unknown etiology (CKDu) hotspot area of Sri Lanka. The high seroprevalence of anti-hantavirus antibodies against Thailand orthohantavirus (THAIV) has been reported among CKDu patients and rodents in Sri Lankan CKDu hotspots. We captured 116 small mammals from CKDu endemic regions in the Polonnaruwa District of Sri Lanka. Seven animals (five out of 11 Mus booduga and two out of 99 Rattus rattus) were PCR-positive for the hantavirus. A rat-borne sequence was grouped with a THAIV-like Anjozorobe virus. In contrast, Mus-borne sequences belonged to the THAIV lineage, suggesting a novel orthohantavirus species according to the phylogenetic analyses and whole-genome comparisons. Our genetic evidence indicates the presence of two THAIV-related viruses circulating in this CKDu endemic area, suggesting a basis for further investigations to identify the infectious virus in patients with CKDu and the CKDu induction mechanism of these viruses. |
format |
Text |
author |
Devinda S. Muthusinghe Kenta Shimizu Sithumini M. W. Lokupathirage Zhouoxing Wei Yomani D. Sarathkumara G. R. Amanda Fonseka Pavani Senarathne Nobuo Koizumi Tomonori Kawakami Akio Koizumi Chaminda Wickramasinghe Hideki Ebihara Keita Matsuno Yoshimi Tsuda Jiro Arikawa Chandika D. Gamage Kumiko Yoshimatsu |
author_facet |
Devinda S. Muthusinghe Kenta Shimizu Sithumini M. W. Lokupathirage Zhouoxing Wei Yomani D. Sarathkumara G. R. Amanda Fonseka Pavani Senarathne Nobuo Koizumi Tomonori Kawakami Akio Koizumi Chaminda Wickramasinghe Hideki Ebihara Keita Matsuno Yoshimi Tsuda Jiro Arikawa Chandika D. Gamage Kumiko Yoshimatsu |
author_sort |
Devinda S. Muthusinghe |
title |
Identification of Novel Rodent-Borne Orthohantaviruses in an Endemic Area of Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka |
title_short |
Identification of Novel Rodent-Borne Orthohantaviruses in an Endemic Area of Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka |
title_full |
Identification of Novel Rodent-Borne Orthohantaviruses in an Endemic Area of Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka |
title_fullStr |
Identification of Novel Rodent-Borne Orthohantaviruses in an Endemic Area of Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka |
title_full_unstemmed |
Identification of Novel Rodent-Borne Orthohantaviruses in an Endemic Area of Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka |
title_sort |
identification of novel rodent-borne orthohantaviruses in an endemic area of chronic kidney disease of unknown etiology (ckdu) in sri lanka |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2021 |
url |
https://doi.org/10.3390/v13101984 |
op_coverage |
agris |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_source |
Viruses; Volume 13; Issue 10; Pages: 1984 |
op_relation |
Animal Viruses https://dx.doi.org/10.3390/v13101984 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/v13101984 |
container_title |
Viruses |
container_volume |
13 |
container_issue |
10 |
container_start_page |
1984 |
_version_ |
1774722362162282496 |