Newlavirus, a Novel, Highly Prevalent, and Highly Diverse Protoparvovirus of Foxes (Vulpes spp.)
The genus Protoparvovirus (family Parvoviridae) includes several viruses of carnivores. We describe a novel fox protoparvovirus, which we named Newlavirus as it was discovered in samples from Newfoundland and Labrador, Canada. Analysis of the full non-structural protein (NS1) sequence indicates that...
Published in: | Viruses |
---|---|
Main Authors: | , , , , , , , , , |
Format: | Text |
Language: | English |
Published: |
Multidisciplinary Digital Publishing Institute
2021
|
Subjects: | |
Online Access: | https://doi.org/10.3390/v13101969 |
id |
ftmdpi:oai:mdpi.com:/1999-4915/13/10/1969/ |
---|---|
record_format |
openpolar |
spelling |
ftmdpi:oai:mdpi.com:/1999-4915/13/10/1969/ 2023-08-20T04:08:03+02:00 Newlavirus, a Novel, Highly Prevalent, and Highly Diverse Protoparvovirus of Foxes (Vulpes spp.) Marta Canuti Émilie Bouchard Bruce Rodrigues Hugh Whitney Marti Hopson Cornelia Gilroy Garry Stenson Suzanne Dufour Andrew Lang Joost Verhoeven agris 2021-09-30 application/pdf https://doi.org/10.3390/v13101969 EN eng Multidisciplinary Digital Publishing Institute Animal Viruses https://dx.doi.org/10.3390/v13101969 https://creativecommons.org/licenses/by/4.0/ Viruses; Volume 13; Issue 10; Pages: 1969 protoparvovirus parvovirus virus discovery fox carnivore Text 2021 ftmdpi https://doi.org/10.3390/v13101969 2023-08-01T02:51:09Z The genus Protoparvovirus (family Parvoviridae) includes several viruses of carnivores. We describe a novel fox protoparvovirus, which we named Newlavirus as it was discovered in samples from Newfoundland and Labrador, Canada. Analysis of the full non-structural protein (NS1) sequence indicates that this virus is a previously uncharacterized species. Newlavirus showed high prevalence in foxes from both the mainland (Labrador, 54/137, 39.4%) and the island of Newfoundland (22/50, 44%) but was not detected in samples from other carnivores, including coyotes (n = 92), lynx (n = 58), martens (n = 146), mink (n = 47), ermines (n = 17), dogs (n = 48), and ringed (n = 4), harp (n = 6), bearded (n = 6), and harbor (n = 2) seals. Newlavirus was found at similar rates in stool and spleen (24/80, 30% vs. 59/152, 38.8%, p = 0.2) but at lower rates in lymph nodes (2/37, 5.4%, p < 0.01). Sequencing a fragment of approximately 750 nt of the capsid protein gene from 53 samples showed a high frequency of co-infection by more than one strain (33.9%), high genetic diversity with 13 genotypes with low sequence identities (70.5–87.8%), and no geographic segregation of strains. Given the high prevalence, high diversity, and the lack of identification in other species, foxes are likely the natural reservoir of Newlavirus, and further studies should investigate its distribution. Text Newfoundland Lynx MDPI Open Access Publishing Canada Newfoundland Viruses 13 10 1969 |
institution |
Open Polar |
collection |
MDPI Open Access Publishing |
op_collection_id |
ftmdpi |
language |
English |
topic |
protoparvovirus parvovirus virus discovery fox carnivore |
spellingShingle |
protoparvovirus parvovirus virus discovery fox carnivore Marta Canuti Émilie Bouchard Bruce Rodrigues Hugh Whitney Marti Hopson Cornelia Gilroy Garry Stenson Suzanne Dufour Andrew Lang Joost Verhoeven Newlavirus, a Novel, Highly Prevalent, and Highly Diverse Protoparvovirus of Foxes (Vulpes spp.) |
topic_facet |
protoparvovirus parvovirus virus discovery fox carnivore |
description |
The genus Protoparvovirus (family Parvoviridae) includes several viruses of carnivores. We describe a novel fox protoparvovirus, which we named Newlavirus as it was discovered in samples from Newfoundland and Labrador, Canada. Analysis of the full non-structural protein (NS1) sequence indicates that this virus is a previously uncharacterized species. Newlavirus showed high prevalence in foxes from both the mainland (Labrador, 54/137, 39.4%) and the island of Newfoundland (22/50, 44%) but was not detected in samples from other carnivores, including coyotes (n = 92), lynx (n = 58), martens (n = 146), mink (n = 47), ermines (n = 17), dogs (n = 48), and ringed (n = 4), harp (n = 6), bearded (n = 6), and harbor (n = 2) seals. Newlavirus was found at similar rates in stool and spleen (24/80, 30% vs. 59/152, 38.8%, p = 0.2) but at lower rates in lymph nodes (2/37, 5.4%, p < 0.01). Sequencing a fragment of approximately 750 nt of the capsid protein gene from 53 samples showed a high frequency of co-infection by more than one strain (33.9%), high genetic diversity with 13 genotypes with low sequence identities (70.5–87.8%), and no geographic segregation of strains. Given the high prevalence, high diversity, and the lack of identification in other species, foxes are likely the natural reservoir of Newlavirus, and further studies should investigate its distribution. |
format |
Text |
author |
Marta Canuti Émilie Bouchard Bruce Rodrigues Hugh Whitney Marti Hopson Cornelia Gilroy Garry Stenson Suzanne Dufour Andrew Lang Joost Verhoeven |
author_facet |
Marta Canuti Émilie Bouchard Bruce Rodrigues Hugh Whitney Marti Hopson Cornelia Gilroy Garry Stenson Suzanne Dufour Andrew Lang Joost Verhoeven |
author_sort |
Marta Canuti |
title |
Newlavirus, a Novel, Highly Prevalent, and Highly Diverse Protoparvovirus of Foxes (Vulpes spp.) |
title_short |
Newlavirus, a Novel, Highly Prevalent, and Highly Diverse Protoparvovirus of Foxes (Vulpes spp.) |
title_full |
Newlavirus, a Novel, Highly Prevalent, and Highly Diverse Protoparvovirus of Foxes (Vulpes spp.) |
title_fullStr |
Newlavirus, a Novel, Highly Prevalent, and Highly Diverse Protoparvovirus of Foxes (Vulpes spp.) |
title_full_unstemmed |
Newlavirus, a Novel, Highly Prevalent, and Highly Diverse Protoparvovirus of Foxes (Vulpes spp.) |
title_sort |
newlavirus, a novel, highly prevalent, and highly diverse protoparvovirus of foxes (vulpes spp.) |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2021 |
url |
https://doi.org/10.3390/v13101969 |
op_coverage |
agris |
geographic |
Canada Newfoundland |
geographic_facet |
Canada Newfoundland |
genre |
Newfoundland Lynx |
genre_facet |
Newfoundland Lynx |
op_source |
Viruses; Volume 13; Issue 10; Pages: 1969 |
op_relation |
Animal Viruses https://dx.doi.org/10.3390/v13101969 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/v13101969 |
container_title |
Viruses |
container_volume |
13 |
container_issue |
10 |
container_start_page |
1969 |
_version_ |
1774720126323523584 |