Antiviral Defense and Innate Immune Memory in the Oyster
The Pacific oyster, Crassostrea gigas, is becoming a valuable model for investigating antiviral defense in the Lophotrochozoa superphylum. In the past five years, improvements to laboratory-based experimental infection protocols using Ostreid herpesvirus I (OsHV-1) from naturally infected C. gigas c...
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ftmdpi:oai:mdpi.com:/1999-4915/10/3/133/ 2023-08-20T04:06:04+02:00 Antiviral Defense and Innate Immune Memory in the Oyster Timothy Green Peter Speck agris 2018-03-16 application/pdf https://doi.org/10.3390/v10030133 EN eng Multidisciplinary Digital Publishing Institute Insect Viruses https://dx.doi.org/10.3390/v10030133 https://creativecommons.org/licenses/by/4.0/ Viruses; Volume 10; Issue 3; Pages: 133 Crassostrea OsHV-1 immune priming interferon RNAi Text 2018 ftmdpi https://doi.org/10.3390/v10030133 2023-07-31T21:26:00Z The Pacific oyster, Crassostrea gigas, is becoming a valuable model for investigating antiviral defense in the Lophotrochozoa superphylum. In the past five years, improvements to laboratory-based experimental infection protocols using Ostreid herpesvirus I (OsHV-1) from naturally infected C. gigas combined with next-generation sequencing techniques has revealed that oysters have a complex antiviral response involving the activation of all major innate immune pathways. Experimental evidence indicates C. gigas utilizes an interferon-like response to limit OsHV-1 replication and spread. Oysters injected with a viral mimic (polyI:C) develop resistance to OsHV-1. Improved survival following polyI:C injection was found later in life (within-generational immune priming) and in the next generation (multi-generational immune priming). These studies indicate that the oyster’s antiviral defense system exhibits a form of innate immune-memory. An important priority is to identify the molecular mechanisms responsible for this phenomenon. This knowledge will motivate the development of practical and cost-effective treatments for improving oyster health in aquaculture. Text Crassostrea gigas Pacific oyster MDPI Open Access Publishing Pacific Viruses 10 3 133 |
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MDPI Open Access Publishing |
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ftmdpi |
language |
English |
topic |
Crassostrea OsHV-1 immune priming interferon RNAi |
spellingShingle |
Crassostrea OsHV-1 immune priming interferon RNAi Timothy Green Peter Speck Antiviral Defense and Innate Immune Memory in the Oyster |
topic_facet |
Crassostrea OsHV-1 immune priming interferon RNAi |
description |
The Pacific oyster, Crassostrea gigas, is becoming a valuable model for investigating antiviral defense in the Lophotrochozoa superphylum. In the past five years, improvements to laboratory-based experimental infection protocols using Ostreid herpesvirus I (OsHV-1) from naturally infected C. gigas combined with next-generation sequencing techniques has revealed that oysters have a complex antiviral response involving the activation of all major innate immune pathways. Experimental evidence indicates C. gigas utilizes an interferon-like response to limit OsHV-1 replication and spread. Oysters injected with a viral mimic (polyI:C) develop resistance to OsHV-1. Improved survival following polyI:C injection was found later in life (within-generational immune priming) and in the next generation (multi-generational immune priming). These studies indicate that the oyster’s antiviral defense system exhibits a form of innate immune-memory. An important priority is to identify the molecular mechanisms responsible for this phenomenon. This knowledge will motivate the development of practical and cost-effective treatments for improving oyster health in aquaculture. |
format |
Text |
author |
Timothy Green Peter Speck |
author_facet |
Timothy Green Peter Speck |
author_sort |
Timothy Green |
title |
Antiviral Defense and Innate Immune Memory in the Oyster |
title_short |
Antiviral Defense and Innate Immune Memory in the Oyster |
title_full |
Antiviral Defense and Innate Immune Memory in the Oyster |
title_fullStr |
Antiviral Defense and Innate Immune Memory in the Oyster |
title_full_unstemmed |
Antiviral Defense and Innate Immune Memory in the Oyster |
title_sort |
antiviral defense and innate immune memory in the oyster |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2018 |
url |
https://doi.org/10.3390/v10030133 |
op_coverage |
agris |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_source |
Viruses; Volume 10; Issue 3; Pages: 133 |
op_relation |
Insect Viruses https://dx.doi.org/10.3390/v10030133 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/v10030133 |
container_title |
Viruses |
container_volume |
10 |
container_issue |
3 |
container_start_page |
133 |
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1774716973512392704 |