An Investigation of the Wild Rat Crown Incisor as an Indicator of Lead (Pb) Exposure Using Inductively Couple Plasma Mass Spectrometry (ICP-MS) and Laser Ablation ICP-MS
Lead (Pb) is a metal toxicant of great public health concern. The present study investigated the applicability of the rat incisor in Pb exposure screening. The levels of lead in teeth (Pb-T) in the crown and root of incisors in laboratory Pb-exposed Sprague Dawley rats were quantified using inductiv...
Published in: | International Journal of Environmental Research and Public Health |
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Online Access: | https://doi.org/10.3390/ijerph18020767 |
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ftmdpi:oai:mdpi.com:/1660-4601/18/2/767/ 2023-08-20T04:09:26+02:00 An Investigation of the Wild Rat Crown Incisor as an Indicator of Lead (Pb) Exposure Using Inductively Couple Plasma Mass Spectrometry (ICP-MS) and Laser Ablation ICP-MS Andrew Kataba Shouta M. M. Nakayama Hokuto Nakata Haruya Toyomaki Yared B. Yohannes John Yabe Kaampwe Muzandu Golden Zyambo Ayano Kubota Takehisa Matsukawa Kazuhito Yokoyama Yoshinori Ikenaka Mayumi Ishizuka agris 2021-01-18 application/pdf https://doi.org/10.3390/ijerph18020767 EN eng Multidisciplinary Digital Publishing Institute Environmental Health https://dx.doi.org/10.3390/ijerph18020767 https://creativecommons.org/licenses/by/4.0/ International Journal of Environmental Research and Public Health; Volume 18; Issue 2; Pages: 767 lead incisor biomarker sentinel wild rodent Text 2021 ftmdpi https://doi.org/10.3390/ijerph18020767 2023-08-01T00:53:07Z Lead (Pb) is a metal toxicant of great public health concern. The present study investigated the applicability of the rat incisor in Pb exposure screening. The levels of lead in teeth (Pb-T) in the crown and root of incisors in laboratory Pb-exposed Sprague Dawley rats were quantified using inductively coupled plasma mass spectrometry (ICP-MS). The crown accumulated much Pb-T than the root of the Sprague Dawley rat incisor. The levels of lead in blood (Pb-B) were positively correlated with the Pb-T in the crown and root incisors of the Sprague Dawley rats. As an application of the Pb-T crown results in experimental rats, we subsequently analyzed the Pb-T in the crown incisors of Pb-exposed wild rats (Rattus rattus) sampled from residential sites within varying distances from an abandoned lead–zinc mine. The Pb-T accumulation in the crown of incisors of R. rattus rats decreased with increased distance away from the Pb–Zn mine. Furthermore, the Pb-T was strongly correlated (r = 0.85) with the Pb levels in the blood. Laser ablation ICP-MS Pb-T mappings revealed a homogenous distribution of Pb in the incisor with an increased intensity of Pb-T localized in the tip of the incisor crown bearing an enamel surface in both Sprague Dawley and R. rattus rats. These findings suggest that Pb-T in the crown incisor may be reflective of the rat’s environmental habitat, thus a possible indicator of Pb exposure. Text Rattus rattus MDPI Open Access Publishing International Journal of Environmental Research and Public Health 18 2 767 |
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Open Polar |
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MDPI Open Access Publishing |
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ftmdpi |
language |
English |
topic |
lead incisor biomarker sentinel wild rodent |
spellingShingle |
lead incisor biomarker sentinel wild rodent Andrew Kataba Shouta M. M. Nakayama Hokuto Nakata Haruya Toyomaki Yared B. Yohannes John Yabe Kaampwe Muzandu Golden Zyambo Ayano Kubota Takehisa Matsukawa Kazuhito Yokoyama Yoshinori Ikenaka Mayumi Ishizuka An Investigation of the Wild Rat Crown Incisor as an Indicator of Lead (Pb) Exposure Using Inductively Couple Plasma Mass Spectrometry (ICP-MS) and Laser Ablation ICP-MS |
topic_facet |
lead incisor biomarker sentinel wild rodent |
description |
Lead (Pb) is a metal toxicant of great public health concern. The present study investigated the applicability of the rat incisor in Pb exposure screening. The levels of lead in teeth (Pb-T) in the crown and root of incisors in laboratory Pb-exposed Sprague Dawley rats were quantified using inductively coupled plasma mass spectrometry (ICP-MS). The crown accumulated much Pb-T than the root of the Sprague Dawley rat incisor. The levels of lead in blood (Pb-B) were positively correlated with the Pb-T in the crown and root incisors of the Sprague Dawley rats. As an application of the Pb-T crown results in experimental rats, we subsequently analyzed the Pb-T in the crown incisors of Pb-exposed wild rats (Rattus rattus) sampled from residential sites within varying distances from an abandoned lead–zinc mine. The Pb-T accumulation in the crown of incisors of R. rattus rats decreased with increased distance away from the Pb–Zn mine. Furthermore, the Pb-T was strongly correlated (r = 0.85) with the Pb levels in the blood. Laser ablation ICP-MS Pb-T mappings revealed a homogenous distribution of Pb in the incisor with an increased intensity of Pb-T localized in the tip of the incisor crown bearing an enamel surface in both Sprague Dawley and R. rattus rats. These findings suggest that Pb-T in the crown incisor may be reflective of the rat’s environmental habitat, thus a possible indicator of Pb exposure. |
format |
Text |
author |
Andrew Kataba Shouta M. M. Nakayama Hokuto Nakata Haruya Toyomaki Yared B. Yohannes John Yabe Kaampwe Muzandu Golden Zyambo Ayano Kubota Takehisa Matsukawa Kazuhito Yokoyama Yoshinori Ikenaka Mayumi Ishizuka |
author_facet |
Andrew Kataba Shouta M. M. Nakayama Hokuto Nakata Haruya Toyomaki Yared B. Yohannes John Yabe Kaampwe Muzandu Golden Zyambo Ayano Kubota Takehisa Matsukawa Kazuhito Yokoyama Yoshinori Ikenaka Mayumi Ishizuka |
author_sort |
Andrew Kataba |
title |
An Investigation of the Wild Rat Crown Incisor as an Indicator of Lead (Pb) Exposure Using Inductively Couple Plasma Mass Spectrometry (ICP-MS) and Laser Ablation ICP-MS |
title_short |
An Investigation of the Wild Rat Crown Incisor as an Indicator of Lead (Pb) Exposure Using Inductively Couple Plasma Mass Spectrometry (ICP-MS) and Laser Ablation ICP-MS |
title_full |
An Investigation of the Wild Rat Crown Incisor as an Indicator of Lead (Pb) Exposure Using Inductively Couple Plasma Mass Spectrometry (ICP-MS) and Laser Ablation ICP-MS |
title_fullStr |
An Investigation of the Wild Rat Crown Incisor as an Indicator of Lead (Pb) Exposure Using Inductively Couple Plasma Mass Spectrometry (ICP-MS) and Laser Ablation ICP-MS |
title_full_unstemmed |
An Investigation of the Wild Rat Crown Incisor as an Indicator of Lead (Pb) Exposure Using Inductively Couple Plasma Mass Spectrometry (ICP-MS) and Laser Ablation ICP-MS |
title_sort |
investigation of the wild rat crown incisor as an indicator of lead (pb) exposure using inductively couple plasma mass spectrometry (icp-ms) and laser ablation icp-ms |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2021 |
url |
https://doi.org/10.3390/ijerph18020767 |
op_coverage |
agris |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_source |
International Journal of Environmental Research and Public Health; Volume 18; Issue 2; Pages: 767 |
op_relation |
Environmental Health https://dx.doi.org/10.3390/ijerph18020767 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/ijerph18020767 |
container_title |
International Journal of Environmental Research and Public Health |
container_volume |
18 |
container_issue |
2 |
container_start_page |
767 |
_version_ |
1774722376420818944 |