Risk Factors for Ventricular Septal Defects in Murmansk County, Russia: A Registry-Based Study
Cardiovascular malformations are one of the most common birth defects among newborns and constitute a leading cause of perinatal and infant mortality. Although some risk factors are recognized, the causes of cardiovascular malformations (CVMs) remain largely unknown. In this study, we aim to identif...
Published in: | International Journal of Environmental Research and Public Health |
---|---|
Main Authors: | , , , , , |
Format: | Text |
Language: | English |
Published: |
Multidisciplinary Digital Publishing Institute
2018
|
Subjects: | |
Online Access: | https://doi.org/10.3390/ijerph15071320 |
id |
ftmdpi:oai:mdpi.com:/1660-4601/15/7/1320/ |
---|---|
record_format |
openpolar |
spelling |
ftmdpi:oai:mdpi.com:/1660-4601/15/7/1320/ 2023-08-20T04:08:49+02:00 Risk Factors for Ventricular Septal Defects in Murmansk County, Russia: A Registry-Based Study Anton A. Kovalenko Erik Eik Anda Jon Øyvind Odland Evert Nieboer Tormod Brenn Alexandra Krettek agris 2018-06-24 application/pdf https://doi.org/10.3390/ijerph15071320 EN eng Multidisciplinary Digital Publishing Institute Health Behavior, Chronic Disease and Health Promotion https://dx.doi.org/10.3390/ijerph15071320 https://creativecommons.org/licenses/by/4.0/ International Journal of Environmental Research and Public Health; Volume 15; Issue 7; Pages: 1320 registry risk factors ventricular septal defects Text 2018 ftmdpi https://doi.org/10.3390/ijerph15071320 2023-07-31T21:35:30Z Cardiovascular malformations are one of the most common birth defects among newborns and constitute a leading cause of perinatal and infant mortality. Although some risk factors are recognized, the causes of cardiovascular malformations (CVMs) remain largely unknown. In this study, we aim to identify risk factors for ventricular septal defects (VSDs) in Northwest Russia. The study population included singleton births registered in the Murmansk County Birth Registry (MCBR) between 1 January 2006 and 31 December 2011. Infants with a diagnosis of VSD in the MCBR and/or in the Murmansk Regional Congenital Defects Registry (up to two years post-delivery) constituted the study sample. Among the 52,253 infants born during the study period there were 744 cases of septal heart defects (SHDs), which corresponds to a prevalence of 14.2 [95% confidence interval (CI) of 13.2–15.3] per 1000 infants. Logistic regression analyses were carried out to identify VSD risk factors. Increased risk of VSDs was observed among infants born to mothers who abused alcohol [OR = 4.83; 95% CI 1.88–12.41], or smoked during pregnancy [OR = 1.35; 95% CI 1.02–1.80]. Maternal diabetes mellitus was also a significant risk factor [OR = 8.72; 95% CI 3.16–24.07], while maternal age, body mass index, folic acid and multivitamin intake were not associated with increased risk. Overall risks of VSDs for male babies were lower [OR = 0.67; 95% CI 0.52–0.88]. Text Northwest Russia MDPI Open Access Publishing Murmansk International Journal of Environmental Research and Public Health 15 7 1320 |
institution |
Open Polar |
collection |
MDPI Open Access Publishing |
op_collection_id |
ftmdpi |
language |
English |
topic |
registry risk factors ventricular septal defects |
spellingShingle |
registry risk factors ventricular septal defects Anton A. Kovalenko Erik Eik Anda Jon Øyvind Odland Evert Nieboer Tormod Brenn Alexandra Krettek Risk Factors for Ventricular Septal Defects in Murmansk County, Russia: A Registry-Based Study |
topic_facet |
registry risk factors ventricular septal defects |
description |
Cardiovascular malformations are one of the most common birth defects among newborns and constitute a leading cause of perinatal and infant mortality. Although some risk factors are recognized, the causes of cardiovascular malformations (CVMs) remain largely unknown. In this study, we aim to identify risk factors for ventricular septal defects (VSDs) in Northwest Russia. The study population included singleton births registered in the Murmansk County Birth Registry (MCBR) between 1 January 2006 and 31 December 2011. Infants with a diagnosis of VSD in the MCBR and/or in the Murmansk Regional Congenital Defects Registry (up to two years post-delivery) constituted the study sample. Among the 52,253 infants born during the study period there were 744 cases of septal heart defects (SHDs), which corresponds to a prevalence of 14.2 [95% confidence interval (CI) of 13.2–15.3] per 1000 infants. Logistic regression analyses were carried out to identify VSD risk factors. Increased risk of VSDs was observed among infants born to mothers who abused alcohol [OR = 4.83; 95% CI 1.88–12.41], or smoked during pregnancy [OR = 1.35; 95% CI 1.02–1.80]. Maternal diabetes mellitus was also a significant risk factor [OR = 8.72; 95% CI 3.16–24.07], while maternal age, body mass index, folic acid and multivitamin intake were not associated with increased risk. Overall risks of VSDs for male babies were lower [OR = 0.67; 95% CI 0.52–0.88]. |
format |
Text |
author |
Anton A. Kovalenko Erik Eik Anda Jon Øyvind Odland Evert Nieboer Tormod Brenn Alexandra Krettek |
author_facet |
Anton A. Kovalenko Erik Eik Anda Jon Øyvind Odland Evert Nieboer Tormod Brenn Alexandra Krettek |
author_sort |
Anton A. Kovalenko |
title |
Risk Factors for Ventricular Septal Defects in Murmansk County, Russia: A Registry-Based Study |
title_short |
Risk Factors for Ventricular Septal Defects in Murmansk County, Russia: A Registry-Based Study |
title_full |
Risk Factors for Ventricular Septal Defects in Murmansk County, Russia: A Registry-Based Study |
title_fullStr |
Risk Factors for Ventricular Septal Defects in Murmansk County, Russia: A Registry-Based Study |
title_full_unstemmed |
Risk Factors for Ventricular Septal Defects in Murmansk County, Russia: A Registry-Based Study |
title_sort |
risk factors for ventricular septal defects in murmansk county, russia: a registry-based study |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2018 |
url |
https://doi.org/10.3390/ijerph15071320 |
op_coverage |
agris |
geographic |
Murmansk |
geographic_facet |
Murmansk |
genre |
Northwest Russia |
genre_facet |
Northwest Russia |
op_source |
International Journal of Environmental Research and Public Health; Volume 15; Issue 7; Pages: 1320 |
op_relation |
Health Behavior, Chronic Disease and Health Promotion https://dx.doi.org/10.3390/ijerph15071320 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/ijerph15071320 |
container_title |
International Journal of Environmental Research and Public Health |
container_volume |
15 |
container_issue |
7 |
container_start_page |
1320 |
_version_ |
1774721322102816768 |