The Urban-Rural Gradient In Asthma: A Population-Based Study in Northern Europe
The early life environment appears to have a persistent impact on asthma risk. We hypothesize that environmental factors related to rural life mediate lower asthma prevalence in rural populations, and aimed to investigate an urban-rural gradient, assessed by place of upbringing, for asthma. The popu...
Published in: | International Journal of Environmental Research and Public Health |
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Online Access: | https://doi.org/10.3390/ijerph13010093 |
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ftmdpi:oai:mdpi.com:/1660-4601/13/1/93/ 2023-08-20T04:07:29+02:00 The Urban-Rural Gradient In Asthma: A Population-Based Study in Northern Europe Signe Timm Morten Frydenberg Christer Janson Brittany Campbell Bertil Forsberg Thorarinn Gislason Mathias Holm Rain Jogi Ernst Omenaas Torben Sigsgaard Cecilie Svanes Vivi Schlünssen agris 2015-12-30 application/pdf https://doi.org/10.3390/ijerph13010093 EN eng Multidisciplinary Digital Publishing Institute https://dx.doi.org/10.3390/ijerph13010093 https://creativecommons.org/licenses/by/4.0/ International Journal of Environmental Research and Public Health; Volume 13; Issue 1; Pages: 93 asthma early life environment farming microbial exposure urban-rural gradient hygiene hypothesis RHINE Text 2015 ftmdpi https://doi.org/10.3390/ijerph13010093 2023-07-31T20:49:13Z The early life environment appears to have a persistent impact on asthma risk. We hypothesize that environmental factors related to rural life mediate lower asthma prevalence in rural populations, and aimed to investigate an urban-rural gradient, assessed by place of upbringing, for asthma. The population-based Respiratory Health In Northern Europe (RHINE) study includes subjects from Denmark, Norway, Sweden, Iceland and Estonia born 1945–1973. The present analysis encompasses questionnaire data on 11,123 RHINE subjects. Six categories of place of upbringing were defined: farm with livestock, farm without livestock, village in rural area, small town, city suburb and inner city. The association of place of upbringing with asthma onset was analysed with Cox regression adjusted for relevant confounders. Subjects growing up on livestock farms had less asthma (8%) than subjects growing up in inner cities (11%) (hazard ratio 0.72 95% CI 0.57–0.91), and a significant urban-rural gradient was observed across six urbanisation levels (p = 0.02). An urban-rural gradient was only evident among women, smokers and for late-onset asthma. Analyses on wheeze and place of upbringing revealed similar results. In conclusion, this study suggests a protective effect of livestock farm upbringing on asthma development and an urban-rural gradient in a Northern European population. Text Iceland MDPI Open Access Publishing Norway International Journal of Environmental Research and Public Health 13 1 93 |
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MDPI Open Access Publishing |
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ftmdpi |
language |
English |
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asthma early life environment farming microbial exposure urban-rural gradient hygiene hypothesis RHINE |
spellingShingle |
asthma early life environment farming microbial exposure urban-rural gradient hygiene hypothesis RHINE Signe Timm Morten Frydenberg Christer Janson Brittany Campbell Bertil Forsberg Thorarinn Gislason Mathias Holm Rain Jogi Ernst Omenaas Torben Sigsgaard Cecilie Svanes Vivi Schlünssen The Urban-Rural Gradient In Asthma: A Population-Based Study in Northern Europe |
topic_facet |
asthma early life environment farming microbial exposure urban-rural gradient hygiene hypothesis RHINE |
description |
The early life environment appears to have a persistent impact on asthma risk. We hypothesize that environmental factors related to rural life mediate lower asthma prevalence in rural populations, and aimed to investigate an urban-rural gradient, assessed by place of upbringing, for asthma. The population-based Respiratory Health In Northern Europe (RHINE) study includes subjects from Denmark, Norway, Sweden, Iceland and Estonia born 1945–1973. The present analysis encompasses questionnaire data on 11,123 RHINE subjects. Six categories of place of upbringing were defined: farm with livestock, farm without livestock, village in rural area, small town, city suburb and inner city. The association of place of upbringing with asthma onset was analysed with Cox regression adjusted for relevant confounders. Subjects growing up on livestock farms had less asthma (8%) than subjects growing up in inner cities (11%) (hazard ratio 0.72 95% CI 0.57–0.91), and a significant urban-rural gradient was observed across six urbanisation levels (p = 0.02). An urban-rural gradient was only evident among women, smokers and for late-onset asthma. Analyses on wheeze and place of upbringing revealed similar results. In conclusion, this study suggests a protective effect of livestock farm upbringing on asthma development and an urban-rural gradient in a Northern European population. |
format |
Text |
author |
Signe Timm Morten Frydenberg Christer Janson Brittany Campbell Bertil Forsberg Thorarinn Gislason Mathias Holm Rain Jogi Ernst Omenaas Torben Sigsgaard Cecilie Svanes Vivi Schlünssen |
author_facet |
Signe Timm Morten Frydenberg Christer Janson Brittany Campbell Bertil Forsberg Thorarinn Gislason Mathias Holm Rain Jogi Ernst Omenaas Torben Sigsgaard Cecilie Svanes Vivi Schlünssen |
author_sort |
Signe Timm |
title |
The Urban-Rural Gradient In Asthma: A Population-Based Study in Northern Europe |
title_short |
The Urban-Rural Gradient In Asthma: A Population-Based Study in Northern Europe |
title_full |
The Urban-Rural Gradient In Asthma: A Population-Based Study in Northern Europe |
title_fullStr |
The Urban-Rural Gradient In Asthma: A Population-Based Study in Northern Europe |
title_full_unstemmed |
The Urban-Rural Gradient In Asthma: A Population-Based Study in Northern Europe |
title_sort |
urban-rural gradient in asthma: a population-based study in northern europe |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2015 |
url |
https://doi.org/10.3390/ijerph13010093 |
op_coverage |
agris |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
International Journal of Environmental Research and Public Health; Volume 13; Issue 1; Pages: 93 |
op_relation |
https://dx.doi.org/10.3390/ijerph13010093 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/ijerph13010093 |
container_title |
International Journal of Environmental Research and Public Health |
container_volume |
13 |
container_issue |
1 |
container_start_page |
93 |
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1774719146614849536 |