Tetrodotoxin Sensitivity of the Vertebrate Cardiac Na+ Current
Evolutionary origin and physiological significance of the tetrodotoxin (TTX) resistance of the vertebrate cardiac Na+ current (INa) is still unresolved. To this end, TTX sensitivity of the cardiac INa was examined in cardiac myocytes of a cyclostome (lamprey), three teleost fishes (crucian carp, bur...
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Molecular Diversity Preservation International
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ftmdpi:oai:mdpi.com:/1660-3397/9/11/2409/ 2023-08-20T04:05:41+02:00 Tetrodotoxin Sensitivity of the Vertebrate Cardiac Na+ Current Matti Vornanen Minna Hassinen Jaakko Haverinen agris 2011-11-21 application/pdf https://doi.org/10.3390/md9112409 EN eng Molecular Diversity Preservation International https://dx.doi.org/10.3390/md9112409 https://creativecommons.org/licenses/by/3.0/ Marine Drugs; Volume 9; Issue 11; Pages: 2409-2422 evolution of tetrodotoxin sensitivity vertebrate animals cardiac sodium current Text 2011 ftmdpi https://doi.org/10.3390/md9112409 2023-07-31T20:27:39Z Evolutionary origin and physiological significance of the tetrodotoxin (TTX) resistance of the vertebrate cardiac Na+ current (INa) is still unresolved. To this end, TTX sensitivity of the cardiac INa was examined in cardiac myocytes of a cyclostome (lamprey), three teleost fishes (crucian carp, burbot and rainbow trout), a clawed frog, a snake (viper) and a bird (quail). In lamprey, teleost fishes, frog and bird the cardiac INa was highly TTX-sensitive with EC50-values between 1.4 and 6.6 nmol·L−1. In the snake heart, about 80% of the INa was TTX-resistant with EC50 value of 0.65 μmol·L−1, the rest being TTX-sensitive (EC50 = 0.5 nmol·L−1). Although TTX-resistance of the cardiac INa appears to be limited to mammals and reptiles, the presence of TTX-resistant isoform of Na+ channel in the lamprey heart suggest an early evolutionary origin of the TTX-resistance, perhaps in the common ancestor of all vertebrates. Text Burbot MDPI Open Access Publishing Marine Drugs 9 11 2409 2422 |
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MDPI Open Access Publishing |
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ftmdpi |
language |
English |
topic |
evolution of tetrodotoxin sensitivity vertebrate animals cardiac sodium current |
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evolution of tetrodotoxin sensitivity vertebrate animals cardiac sodium current Matti Vornanen Minna Hassinen Jaakko Haverinen Tetrodotoxin Sensitivity of the Vertebrate Cardiac Na+ Current |
topic_facet |
evolution of tetrodotoxin sensitivity vertebrate animals cardiac sodium current |
description |
Evolutionary origin and physiological significance of the tetrodotoxin (TTX) resistance of the vertebrate cardiac Na+ current (INa) is still unresolved. To this end, TTX sensitivity of the cardiac INa was examined in cardiac myocytes of a cyclostome (lamprey), three teleost fishes (crucian carp, burbot and rainbow trout), a clawed frog, a snake (viper) and a bird (quail). In lamprey, teleost fishes, frog and bird the cardiac INa was highly TTX-sensitive with EC50-values between 1.4 and 6.6 nmol·L−1. In the snake heart, about 80% of the INa was TTX-resistant with EC50 value of 0.65 μmol·L−1, the rest being TTX-sensitive (EC50 = 0.5 nmol·L−1). Although TTX-resistance of the cardiac INa appears to be limited to mammals and reptiles, the presence of TTX-resistant isoform of Na+ channel in the lamprey heart suggest an early evolutionary origin of the TTX-resistance, perhaps in the common ancestor of all vertebrates. |
format |
Text |
author |
Matti Vornanen Minna Hassinen Jaakko Haverinen |
author_facet |
Matti Vornanen Minna Hassinen Jaakko Haverinen |
author_sort |
Matti Vornanen |
title |
Tetrodotoxin Sensitivity of the Vertebrate Cardiac Na+ Current |
title_short |
Tetrodotoxin Sensitivity of the Vertebrate Cardiac Na+ Current |
title_full |
Tetrodotoxin Sensitivity of the Vertebrate Cardiac Na+ Current |
title_fullStr |
Tetrodotoxin Sensitivity of the Vertebrate Cardiac Na+ Current |
title_full_unstemmed |
Tetrodotoxin Sensitivity of the Vertebrate Cardiac Na+ Current |
title_sort |
tetrodotoxin sensitivity of the vertebrate cardiac na+ current |
publisher |
Molecular Diversity Preservation International |
publishDate |
2011 |
url |
https://doi.org/10.3390/md9112409 |
op_coverage |
agris |
genre |
Burbot |
genre_facet |
Burbot |
op_source |
Marine Drugs; Volume 9; Issue 11; Pages: 2409-2422 |
op_relation |
https://dx.doi.org/10.3390/md9112409 |
op_rights |
https://creativecommons.org/licenses/by/3.0/ |
op_doi |
https://doi.org/10.3390/md9112409 |
container_title |
Marine Drugs |
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9 |
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11 |
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2409 |
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2422 |
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1774716391026327552 |