In Vivo Skin Hydrating Efficacy of Fish Collagen from Greenland Halibut as a High-Value Active Ingredient for Cosmetic Applications
The industrial processing of fish for food purposes also generates a considerable number of by-products such as viscera, bones, scales, and skin. From a value-added perspective, fish by-products can act also as raw materials, especially because of their collagen content (particularly in fish skin)....
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Online Access: | https://doi.org/10.3390/md21020057 |
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ftmdpi:oai:mdpi.com:/1660-3397/21/2/57/ 2023-08-20T04:06:53+02:00 In Vivo Skin Hydrating Efficacy of Fish Collagen from Greenland Halibut as a High-Value Active Ingredient for Cosmetic Applications Eva Martins Rui L. Reis Tiago H. Silva agris 2023-01-17 application/pdf https://doi.org/10.3390/md21020057 EN eng Multidisciplinary Digital Publishing Institute https://dx.doi.org/10.3390/md21020057 https://creativecommons.org/licenses/by/4.0/ Marine Drugs; Volume 21; Issue 2; Pages: 57 marine collagen cytotoxicity skin cosmetic formulation hydrogel fish by-products in vivo assay hydration Text 2023 ftmdpi https://doi.org/10.3390/md21020057 2023-08-01T08:21:17Z The industrial processing of fish for food purposes also generates a considerable number of by-products such as viscera, bones, scales, and skin. From a value-added perspective, fish by-products can act also as raw materials, especially because of their collagen content (particularly in fish skin). Interestingly, the potential of marine collagen for cosmetic applications is enormous and, remarkably, the extraction of this protein from fish skins has been established for different species. Using this approach, we investigated the integration of marine collagen (COLRp_I) extracted from the skin of the Greenland halibut as an active ingredient in a cosmetic hydrogel formulation. In this study, extracts of marine collagen at concentrations up to 10 mg/mL showed a non-cytotoxic effect when cultured with fibroblast cells for 3 days. In addition, marine collagen extract, when incorporated into a cosmetic hydrogel formulation, met criterion A of ISO 11930:2019 regarding the efficacy of the preservative system (challenge test). In addition, the cosmetic formulations based on marine collagen at dosages of 0.1, 0.25 and 0.5% were tested in a clinical study on the skin of the forearms of 23 healthy volunteers, showing a sightly hydration effect, suggesting its potential for beauty applications. Moreover, this work illustrates that the circular economy concept applied to the fish processing industry can represent important benefits, at innovation, environmental and economic levels. Text Greenland MDPI Open Access Publishing Greenland Marine Drugs 21 2 57 |
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MDPI Open Access Publishing |
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English |
topic |
marine collagen cytotoxicity skin cosmetic formulation hydrogel fish by-products in vivo assay hydration |
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marine collagen cytotoxicity skin cosmetic formulation hydrogel fish by-products in vivo assay hydration Eva Martins Rui L. Reis Tiago H. Silva In Vivo Skin Hydrating Efficacy of Fish Collagen from Greenland Halibut as a High-Value Active Ingredient for Cosmetic Applications |
topic_facet |
marine collagen cytotoxicity skin cosmetic formulation hydrogel fish by-products in vivo assay hydration |
description |
The industrial processing of fish for food purposes also generates a considerable number of by-products such as viscera, bones, scales, and skin. From a value-added perspective, fish by-products can act also as raw materials, especially because of their collagen content (particularly in fish skin). Interestingly, the potential of marine collagen for cosmetic applications is enormous and, remarkably, the extraction of this protein from fish skins has been established for different species. Using this approach, we investigated the integration of marine collagen (COLRp_I) extracted from the skin of the Greenland halibut as an active ingredient in a cosmetic hydrogel formulation. In this study, extracts of marine collagen at concentrations up to 10 mg/mL showed a non-cytotoxic effect when cultured with fibroblast cells for 3 days. In addition, marine collagen extract, when incorporated into a cosmetic hydrogel formulation, met criterion A of ISO 11930:2019 regarding the efficacy of the preservative system (challenge test). In addition, the cosmetic formulations based on marine collagen at dosages of 0.1, 0.25 and 0.5% were tested in a clinical study on the skin of the forearms of 23 healthy volunteers, showing a sightly hydration effect, suggesting its potential for beauty applications. Moreover, this work illustrates that the circular economy concept applied to the fish processing industry can represent important benefits, at innovation, environmental and economic levels. |
format |
Text |
author |
Eva Martins Rui L. Reis Tiago H. Silva |
author_facet |
Eva Martins Rui L. Reis Tiago H. Silva |
author_sort |
Eva Martins |
title |
In Vivo Skin Hydrating Efficacy of Fish Collagen from Greenland Halibut as a High-Value Active Ingredient for Cosmetic Applications |
title_short |
In Vivo Skin Hydrating Efficacy of Fish Collagen from Greenland Halibut as a High-Value Active Ingredient for Cosmetic Applications |
title_full |
In Vivo Skin Hydrating Efficacy of Fish Collagen from Greenland Halibut as a High-Value Active Ingredient for Cosmetic Applications |
title_fullStr |
In Vivo Skin Hydrating Efficacy of Fish Collagen from Greenland Halibut as a High-Value Active Ingredient for Cosmetic Applications |
title_full_unstemmed |
In Vivo Skin Hydrating Efficacy of Fish Collagen from Greenland Halibut as a High-Value Active Ingredient for Cosmetic Applications |
title_sort |
in vivo skin hydrating efficacy of fish collagen from greenland halibut as a high-value active ingredient for cosmetic applications |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2023 |
url |
https://doi.org/10.3390/md21020057 |
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agris |
geographic |
Greenland |
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Greenland |
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Greenland |
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Greenland |
op_source |
Marine Drugs; Volume 21; Issue 2; Pages: 57 |
op_relation |
https://dx.doi.org/10.3390/md21020057 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
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https://doi.org/10.3390/md21020057 |
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Marine Drugs |
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