CATASAN Is a New Anti-Biofilm Agent Produced by the Marine Antarctic Bacterium Psychrobacter sp. TAE2020
The development of new approaches to prevent microbial surface adhesion and biofilm formation is an emerging need following the growing understanding of the impact of biofilm-related infections on human health. Staphylococcus epidermidis, with its ability to form biofilm and colonize biomaterials, r...
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ftmdpi:oai:mdpi.com:/1660-3397/20/12/747/ 2023-10-01T03:51:13+02:00 CATASAN Is a New Anti-Biofilm Agent Produced by the Marine Antarctic Bacterium Psychrobacter sp. TAE2020 Caterina D’Angelo Angela Casillo Chiara Melchiorre Concetta Lauro Maria Michela Corsaro Andrea Carpentieri Maria Luisa Tutino Ermenegilda Parrilli agris 2022-11-27 application/pdf https://doi.org/10.3390/md20120747 eng eng Multidisciplinary Digital Publishing Institute Marine Chemoecology for Drug Discovery https://dx.doi.org/10.3390/md20120747 https://creativecommons.org/licenses/by/4.0/ Marine Drugs Volume 20 Issue 12 Pages: 747 anti-biofilm anti-adhesive bioemulsifier biosurfactant Psychrobacter sp. TAE2020 Text 2022 ftmdpi https://doi.org/10.3390/md20120747 2023-09-03T23:54:42Z The development of new approaches to prevent microbial surface adhesion and biofilm formation is an emerging need following the growing understanding of the impact of biofilm-related infections on human health. Staphylococcus epidermidis, with its ability to form biofilm and colonize biomaterials, represents the most frequent causative agent involved in infections of medical devices. In the research of new anti-biofilm agents against S. epidermidis biofilm, Antarctic marine bacteria represent an untapped reservoir of biodiversity. In the present study, the attention was focused on Psychrobacter sp. TAE2020, an Antarctic marine bacterium that produces molecules able to impair the initial attachment of S. epidermidis strains to the polystyrene surface. The setup of suitable purification protocols allowed the identification by NMR spectroscopy and LC-MS/MS analysis of a protein–polysaccharide complex named CATASAN. This complex proved to be a very effective anti-biofilm agent. Indeed, it not only interferes with cell surface attachment, but also prevents biofilm formation and affects the mature biofilm matrix structure of S. epidermidis. Moreover, CATASAN is endowed with a good emulsification activity in a wide range of pH and temperature. Therefore, its use can be easily extended to different biotechnological applications. Text Antarc* Antarctic MDPI Open Access Publishing Antarctic Marine Drugs 20 12 747 |
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Open Polar |
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MDPI Open Access Publishing |
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ftmdpi |
language |
English |
topic |
anti-biofilm anti-adhesive bioemulsifier biosurfactant Psychrobacter sp. TAE2020 |
spellingShingle |
anti-biofilm anti-adhesive bioemulsifier biosurfactant Psychrobacter sp. TAE2020 Caterina D’Angelo Angela Casillo Chiara Melchiorre Concetta Lauro Maria Michela Corsaro Andrea Carpentieri Maria Luisa Tutino Ermenegilda Parrilli CATASAN Is a New Anti-Biofilm Agent Produced by the Marine Antarctic Bacterium Psychrobacter sp. TAE2020 |
topic_facet |
anti-biofilm anti-adhesive bioemulsifier biosurfactant Psychrobacter sp. TAE2020 |
description |
The development of new approaches to prevent microbial surface adhesion and biofilm formation is an emerging need following the growing understanding of the impact of biofilm-related infections on human health. Staphylococcus epidermidis, with its ability to form biofilm and colonize biomaterials, represents the most frequent causative agent involved in infections of medical devices. In the research of new anti-biofilm agents against S. epidermidis biofilm, Antarctic marine bacteria represent an untapped reservoir of biodiversity. In the present study, the attention was focused on Psychrobacter sp. TAE2020, an Antarctic marine bacterium that produces molecules able to impair the initial attachment of S. epidermidis strains to the polystyrene surface. The setup of suitable purification protocols allowed the identification by NMR spectroscopy and LC-MS/MS analysis of a protein–polysaccharide complex named CATASAN. This complex proved to be a very effective anti-biofilm agent. Indeed, it not only interferes with cell surface attachment, but also prevents biofilm formation and affects the mature biofilm matrix structure of S. epidermidis. Moreover, CATASAN is endowed with a good emulsification activity in a wide range of pH and temperature. Therefore, its use can be easily extended to different biotechnological applications. |
format |
Text |
author |
Caterina D’Angelo Angela Casillo Chiara Melchiorre Concetta Lauro Maria Michela Corsaro Andrea Carpentieri Maria Luisa Tutino Ermenegilda Parrilli |
author_facet |
Caterina D’Angelo Angela Casillo Chiara Melchiorre Concetta Lauro Maria Michela Corsaro Andrea Carpentieri Maria Luisa Tutino Ermenegilda Parrilli |
author_sort |
Caterina D’Angelo |
title |
CATASAN Is a New Anti-Biofilm Agent Produced by the Marine Antarctic Bacterium Psychrobacter sp. TAE2020 |
title_short |
CATASAN Is a New Anti-Biofilm Agent Produced by the Marine Antarctic Bacterium Psychrobacter sp. TAE2020 |
title_full |
CATASAN Is a New Anti-Biofilm Agent Produced by the Marine Antarctic Bacterium Psychrobacter sp. TAE2020 |
title_fullStr |
CATASAN Is a New Anti-Biofilm Agent Produced by the Marine Antarctic Bacterium Psychrobacter sp. TAE2020 |
title_full_unstemmed |
CATASAN Is a New Anti-Biofilm Agent Produced by the Marine Antarctic Bacterium Psychrobacter sp. TAE2020 |
title_sort |
catasan is a new anti-biofilm agent produced by the marine antarctic bacterium psychrobacter sp. tae2020 |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2022 |
url |
https://doi.org/10.3390/md20120747 |
op_coverage |
agris |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
Marine Drugs Volume 20 Issue 12 Pages: 747 |
op_relation |
Marine Chemoecology for Drug Discovery https://dx.doi.org/10.3390/md20120747 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/md20120747 |
container_title |
Marine Drugs |
container_volume |
20 |
container_issue |
12 |
container_start_page |
747 |
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1778533384617721856 |