Ameliorative Effects of Peptides Derived from Oyster (Crassostrea gigas) on Immunomodulatory Function and Gut Microbiota Structure in Cyclophosphamide-Treated Mice
The intestinal flora is recognized as a significant contributor to the immune system. In this research, the protective effects of oyster peptides on immune regulation and intestinal microbiota were investigated in mice treated with cyclophosphamide. The results showed that oyster peptides restored t...
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ftmdpi:oai:mdpi.com:/1660-3397/19/8/456/ 2023-08-20T04:06:02+02:00 Ameliorative Effects of Peptides Derived from Oyster (Crassostrea gigas) on Immunomodulatory Function and Gut Microbiota Structure in Cyclophosphamide-Treated Mice Xing-Wei Xiang Hui-Zhen Zheng Rui Wang Hui Chen Jin-Xing Xiao Bin Zheng Shu-Lai Liu Yu-Ting Ding agris 2021-08-11 application/pdf https://doi.org/10.3390/md19080456 EN eng Multidisciplinary Digital Publishing Institute https://dx.doi.org/10.3390/md19080456 https://creativecommons.org/licenses/by/4.0/ Marine Drugs; Volume 19; Issue 8; Pages: 456 oyster ( Crassostrea gigas ) peptides cyclophosphamide immunomodulatory gut microbiota short-chain fatty acid Text 2021 ftmdpi https://doi.org/10.3390/md19080456 2023-08-01T02:24:27Z The intestinal flora is recognized as a significant contributor to the immune system. In this research, the protective effects of oyster peptides on immune regulation and intestinal microbiota were investigated in mice treated with cyclophosphamide. The results showed that oyster peptides restored the indexes of thymus, spleen and liver, stimulated cytokines secretion and promoted the relative mRNA levels of Th1/Th2 cytokines (IL-2, IFN-γ, IL-4 and IL-10). The mRNA levels of Occludin, Claudin-1, ZO-1, and Mucin-2 were up-regulated, and the NF-κB signaling pathway was also activated after oyster peptides administration. Furthermore, oyster peptides treatment reduced the proportion of Firmicutes/Bacteroidetes, increased the relative abundance of Alistipes, Lactobacillus, Rikenell and the content of short-chain fatty acids, and reversed the composition of intestinal microflora similar to that of normal mice. In conclusion, oyster peptides effectively ameliorated cyclophosphamide-induced intestinal damage and modified gut microbiota structure in mice, and might be utilized as a beneficial ingredient in functional foods for immune regulation. Text Crassostrea gigas MDPI Open Access Publishing Marine Drugs 19 8 456 |
institution |
Open Polar |
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MDPI Open Access Publishing |
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ftmdpi |
language |
English |
topic |
oyster ( Crassostrea gigas ) peptides cyclophosphamide immunomodulatory gut microbiota short-chain fatty acid |
spellingShingle |
oyster ( Crassostrea gigas ) peptides cyclophosphamide immunomodulatory gut microbiota short-chain fatty acid Xing-Wei Xiang Hui-Zhen Zheng Rui Wang Hui Chen Jin-Xing Xiao Bin Zheng Shu-Lai Liu Yu-Ting Ding Ameliorative Effects of Peptides Derived from Oyster (Crassostrea gigas) on Immunomodulatory Function and Gut Microbiota Structure in Cyclophosphamide-Treated Mice |
topic_facet |
oyster ( Crassostrea gigas ) peptides cyclophosphamide immunomodulatory gut microbiota short-chain fatty acid |
description |
The intestinal flora is recognized as a significant contributor to the immune system. In this research, the protective effects of oyster peptides on immune regulation and intestinal microbiota were investigated in mice treated with cyclophosphamide. The results showed that oyster peptides restored the indexes of thymus, spleen and liver, stimulated cytokines secretion and promoted the relative mRNA levels of Th1/Th2 cytokines (IL-2, IFN-γ, IL-4 and IL-10). The mRNA levels of Occludin, Claudin-1, ZO-1, and Mucin-2 were up-regulated, and the NF-κB signaling pathway was also activated after oyster peptides administration. Furthermore, oyster peptides treatment reduced the proportion of Firmicutes/Bacteroidetes, increased the relative abundance of Alistipes, Lactobacillus, Rikenell and the content of short-chain fatty acids, and reversed the composition of intestinal microflora similar to that of normal mice. In conclusion, oyster peptides effectively ameliorated cyclophosphamide-induced intestinal damage and modified gut microbiota structure in mice, and might be utilized as a beneficial ingredient in functional foods for immune regulation. |
format |
Text |
author |
Xing-Wei Xiang Hui-Zhen Zheng Rui Wang Hui Chen Jin-Xing Xiao Bin Zheng Shu-Lai Liu Yu-Ting Ding |
author_facet |
Xing-Wei Xiang Hui-Zhen Zheng Rui Wang Hui Chen Jin-Xing Xiao Bin Zheng Shu-Lai Liu Yu-Ting Ding |
author_sort |
Xing-Wei Xiang |
title |
Ameliorative Effects of Peptides Derived from Oyster (Crassostrea gigas) on Immunomodulatory Function and Gut Microbiota Structure in Cyclophosphamide-Treated Mice |
title_short |
Ameliorative Effects of Peptides Derived from Oyster (Crassostrea gigas) on Immunomodulatory Function and Gut Microbiota Structure in Cyclophosphamide-Treated Mice |
title_full |
Ameliorative Effects of Peptides Derived from Oyster (Crassostrea gigas) on Immunomodulatory Function and Gut Microbiota Structure in Cyclophosphamide-Treated Mice |
title_fullStr |
Ameliorative Effects of Peptides Derived from Oyster (Crassostrea gigas) on Immunomodulatory Function and Gut Microbiota Structure in Cyclophosphamide-Treated Mice |
title_full_unstemmed |
Ameliorative Effects of Peptides Derived from Oyster (Crassostrea gigas) on Immunomodulatory Function and Gut Microbiota Structure in Cyclophosphamide-Treated Mice |
title_sort |
ameliorative effects of peptides derived from oyster (crassostrea gigas) on immunomodulatory function and gut microbiota structure in cyclophosphamide-treated mice |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2021 |
url |
https://doi.org/10.3390/md19080456 |
op_coverage |
agris |
genre |
Crassostrea gigas |
genre_facet |
Crassostrea gigas |
op_source |
Marine Drugs; Volume 19; Issue 8; Pages: 456 |
op_relation |
https://dx.doi.org/10.3390/md19080456 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/md19080456 |
container_title |
Marine Drugs |
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19 |
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8 |
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456 |
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