First Report of OvoA Gene in Marine Arthropods: A New Candidate Stress Biomarker in Copepods
Ovothiol is one of the most powerful antioxidants acting in marine organisms as a defense against oxidative stress during development and in response to environmental cues. The gene involved in the ovothiol biosynthesis, OvoA, is found in almost all metazoans, but open questions existed on its prese...
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ftmdpi:oai:mdpi.com:/1660-3397/19/11/647/ 2023-08-20T04:05:42+02:00 First Report of OvoA Gene in Marine Arthropods: A New Candidate Stress Biomarker in Copepods Vittoria Roncalli Chiara Lauritano Ylenia Carotenuto agris 2021-11-20 application/pdf https://doi.org/10.3390/md19110647 EN eng Multidisciplinary Digital Publishing Institute https://dx.doi.org/10.3390/md19110647 https://creativecommons.org/licenses/by/4.0/ Marine Drugs; Volume 19; Issue 11; Pages: 647 zooplankton natural products antioxidant transcriptome mining Text 2021 ftmdpi https://doi.org/10.3390/md19110647 2023-08-01T03:18:55Z Ovothiol is one of the most powerful antioxidants acting in marine organisms as a defense against oxidative stress during development and in response to environmental cues. The gene involved in the ovothiol biosynthesis, OvoA, is found in almost all metazoans, but open questions existed on its presence among arthropods. Here, using an in silico workflow, we report a single OvoA gene in marine arthropods including copepods, decapods, and amphipods. Phylogenetic analyses indicated that OvoA from marine arthropods separated from the other marine phyla (e.g., Porifera, Mollusca) and divided into two separate branches, suggesting a possible divergence through evolution. In the copepod Calanus finmarchicus, we suggest that OvoA has a defense role in oxidative stress as shown by its high expression in response to a toxic diet and during the copepodite stage, a developmental stage that includes significant morphological changes. Overall, the results of our study open possibilities for the use of OvoA as a biomarker of stress in copepods and possibly also for other marine holozooplankters. The finding of OvoA in copepods is also promising for the drug discovery field, suggesting the possibility of using copepods as a new source of bioactive compounds to be tested in the marine biotechnological sector. Text Calanus finmarchicus Copepods MDPI Open Access Publishing Marine Drugs 19 11 647 |
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MDPI Open Access Publishing |
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English |
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zooplankton natural products antioxidant transcriptome mining |
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zooplankton natural products antioxidant transcriptome mining Vittoria Roncalli Chiara Lauritano Ylenia Carotenuto First Report of OvoA Gene in Marine Arthropods: A New Candidate Stress Biomarker in Copepods |
topic_facet |
zooplankton natural products antioxidant transcriptome mining |
description |
Ovothiol is one of the most powerful antioxidants acting in marine organisms as a defense against oxidative stress during development and in response to environmental cues. The gene involved in the ovothiol biosynthesis, OvoA, is found in almost all metazoans, but open questions existed on its presence among arthropods. Here, using an in silico workflow, we report a single OvoA gene in marine arthropods including copepods, decapods, and amphipods. Phylogenetic analyses indicated that OvoA from marine arthropods separated from the other marine phyla (e.g., Porifera, Mollusca) and divided into two separate branches, suggesting a possible divergence through evolution. In the copepod Calanus finmarchicus, we suggest that OvoA has a defense role in oxidative stress as shown by its high expression in response to a toxic diet and during the copepodite stage, a developmental stage that includes significant morphological changes. Overall, the results of our study open possibilities for the use of OvoA as a biomarker of stress in copepods and possibly also for other marine holozooplankters. The finding of OvoA in copepods is also promising for the drug discovery field, suggesting the possibility of using copepods as a new source of bioactive compounds to be tested in the marine biotechnological sector. |
format |
Text |
author |
Vittoria Roncalli Chiara Lauritano Ylenia Carotenuto |
author_facet |
Vittoria Roncalli Chiara Lauritano Ylenia Carotenuto |
author_sort |
Vittoria Roncalli |
title |
First Report of OvoA Gene in Marine Arthropods: A New Candidate Stress Biomarker in Copepods |
title_short |
First Report of OvoA Gene in Marine Arthropods: A New Candidate Stress Biomarker in Copepods |
title_full |
First Report of OvoA Gene in Marine Arthropods: A New Candidate Stress Biomarker in Copepods |
title_fullStr |
First Report of OvoA Gene in Marine Arthropods: A New Candidate Stress Biomarker in Copepods |
title_full_unstemmed |
First Report of OvoA Gene in Marine Arthropods: A New Candidate Stress Biomarker in Copepods |
title_sort |
first report of ovoa gene in marine arthropods: a new candidate stress biomarker in copepods |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2021 |
url |
https://doi.org/10.3390/md19110647 |
op_coverage |
agris |
genre |
Calanus finmarchicus Copepods |
genre_facet |
Calanus finmarchicus Copepods |
op_source |
Marine Drugs; Volume 19; Issue 11; Pages: 647 |
op_relation |
https://dx.doi.org/10.3390/md19110647 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/md19110647 |
container_title |
Marine Drugs |
container_volume |
19 |
container_issue |
11 |
container_start_page |
647 |
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