Anverenes B–E, New Polyhalogenated Monoterpenes from the Antarctic Red Alga Plocamium cartilagineum

The subtidal red alga Plocamium cartilagineum was collected from the Western Antarctic Peninsula during the 2011 and 2017 austral summers. Bulk collections from specific sites corresponded to chemogroups identified by Young et al. in 2013. One of the chemogroups yielded several known acyclic halogen...

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Bibliographic Details
Published in:Marine Drugs
Main Authors: Andrew J. Shilling, Jacqueline L. von Salm, Anthony R. Sanchez, Younghoon Kee, Charles D. Amsler, James B. McClintock, Bill J. Baker
Format: Text
Language:English
Published: Multidisciplinary Digital Publishing Institute 2019
Subjects:
halogenated monoterpenes
anverenes
Plocamium cartilagineum
Antarctic
Antarctic Peninsula
Austral
The Antarctic
Antarc*
Online Access:https://doi.org/10.3390/md17040230
Description
Summary:The subtidal red alga Plocamium cartilagineum was collected from the Western Antarctic Peninsula during the 2011 and 2017 austral summers. Bulk collections from specific sites corresponded to chemogroups identified by Young et al. in 2013. One of the chemogroups yielded several known acyclic halogenated monoterpenes (2–5) as well as undescribed compounds of the same class, anverenes B–D (6–8). Examination of another chemogroup yielded an undescribed cyclic halogenated monoterpene anverene E (9) as its major secondary metabolite. Elucidation of structures was achieved through one-dimensional (1D) and 2D nuclear magnetic resonance (NMR) spectroscopy and negative chemical ionization mass spectrometry. Compounds 1–9 show moderate cytotoxicity against cervical cancer (HeLa) cells.

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