Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp.
The isolation and structural elucidation of a structurally new desertomycin, designated as desertomycin G (1), with strong antibiotic activity against several clinically relevant antibiotic resistant pathogens are described herein. This new natural product was obtained from cultures of the marine ac...
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ftmdpi:oai:mdpi.com:/1660-3397/17/2/114/ 2023-08-20T04:08:40+02:00 Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp. Alfredo F. Braña Aida Sarmiento-Vizcaíno Ignacio Pérez-Victoria Jesús Martín Luis Otero Juan José Palacios-Gutiérrez Jonathan Fernández Yamina Mohamedi Tania Fontanil Marina Salmón Santiago Cal Fernando Reyes Luis A. García Gloria Blanco agris 2019-02-12 application/pdf https://doi.org/10.3390/md17020114 EN eng Multidisciplinary Digital Publishing Institute https://dx.doi.org/10.3390/md17020114 https://creativecommons.org/licenses/by/4.0/ Marine Drugs; Volume 17; Issue 2; Pages: 114 desertomycin macrolide Streptomyces seaweed associated actinobacteria actinomycetes intertidal seaweed Text 2019 ftmdpi https://doi.org/10.3390/md17020114 2023-07-31T22:02:17Z The isolation and structural elucidation of a structurally new desertomycin, designated as desertomycin G (1), with strong antibiotic activity against several clinically relevant antibiotic resistant pathogens are described herein. This new natural product was obtained from cultures of the marine actinomycete Streptomyces althioticus MSM3, isolated from samples of the intertidal seaweed Ulva sp. collected in the Cantabrian Sea (Northeast Atlantic Ocean). Particularly interesting is its strong antibiotic activity against Mycobacterium tuberculosis clinical isolates, resistant to antibiotics in clinical use. To the best of our knowledge, this is the first report on a member of the desertomycin family displaying such activity. Additionally, desertomycin G shows strong antibiotic activities against other relevant Gram-positive clinical pathogens such as Corynebacterium urealyticum, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Enterococcus faecium, Enterococcus faecalis, and Clostridium perfringens. Desertomycin G also displays moderate antibiotic activity against relevant Gram-negative clinical pathogens such as Bacteroides fragilis, Haemophilus influenzae and Neisseria meningitidis. In addition, the compound affects viability of tumor cell lines, such as human breast adenocarcinoma (MCF-7) and colon carcinoma (DLD-1), but not normal mammary fibroblasts. Text Northeast Atlantic MDPI Open Access Publishing Marine Drugs 17 2 114 |
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MDPI Open Access Publishing |
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language |
English |
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desertomycin macrolide Streptomyces seaweed associated actinobacteria actinomycetes intertidal seaweed |
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desertomycin macrolide Streptomyces seaweed associated actinobacteria actinomycetes intertidal seaweed Alfredo F. Braña Aida Sarmiento-Vizcaíno Ignacio Pérez-Victoria Jesús Martín Luis Otero Juan José Palacios-Gutiérrez Jonathan Fernández Yamina Mohamedi Tania Fontanil Marina Salmón Santiago Cal Fernando Reyes Luis A. García Gloria Blanco Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp. |
topic_facet |
desertomycin macrolide Streptomyces seaweed associated actinobacteria actinomycetes intertidal seaweed |
description |
The isolation and structural elucidation of a structurally new desertomycin, designated as desertomycin G (1), with strong antibiotic activity against several clinically relevant antibiotic resistant pathogens are described herein. This new natural product was obtained from cultures of the marine actinomycete Streptomyces althioticus MSM3, isolated from samples of the intertidal seaweed Ulva sp. collected in the Cantabrian Sea (Northeast Atlantic Ocean). Particularly interesting is its strong antibiotic activity against Mycobacterium tuberculosis clinical isolates, resistant to antibiotics in clinical use. To the best of our knowledge, this is the first report on a member of the desertomycin family displaying such activity. Additionally, desertomycin G shows strong antibiotic activities against other relevant Gram-positive clinical pathogens such as Corynebacterium urealyticum, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Enterococcus faecium, Enterococcus faecalis, and Clostridium perfringens. Desertomycin G also displays moderate antibiotic activity against relevant Gram-negative clinical pathogens such as Bacteroides fragilis, Haemophilus influenzae and Neisseria meningitidis. In addition, the compound affects viability of tumor cell lines, such as human breast adenocarcinoma (MCF-7) and colon carcinoma (DLD-1), but not normal mammary fibroblasts. |
format |
Text |
author |
Alfredo F. Braña Aida Sarmiento-Vizcaíno Ignacio Pérez-Victoria Jesús Martín Luis Otero Juan José Palacios-Gutiérrez Jonathan Fernández Yamina Mohamedi Tania Fontanil Marina Salmón Santiago Cal Fernando Reyes Luis A. García Gloria Blanco |
author_facet |
Alfredo F. Braña Aida Sarmiento-Vizcaíno Ignacio Pérez-Victoria Jesús Martín Luis Otero Juan José Palacios-Gutiérrez Jonathan Fernández Yamina Mohamedi Tania Fontanil Marina Salmón Santiago Cal Fernando Reyes Luis A. García Gloria Blanco |
author_sort |
Alfredo F. Braña |
title |
Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp. |
title_short |
Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp. |
title_full |
Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp. |
title_fullStr |
Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp. |
title_full_unstemmed |
Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp. |
title_sort |
desertomycin g, a new antibiotic with activity against mycobacterium tuberculosis and human breast tumor cell lines produced by streptomyces althioticus msm3, isolated from the cantabrian sea intertidal macroalgae ulva sp. |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2019 |
url |
https://doi.org/10.3390/md17020114 |
op_coverage |
agris |
genre |
Northeast Atlantic |
genre_facet |
Northeast Atlantic |
op_source |
Marine Drugs; Volume 17; Issue 2; Pages: 114 |
op_relation |
https://dx.doi.org/10.3390/md17020114 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/md17020114 |
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Marine Drugs |
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17 |
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2 |
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114 |
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