Sesterterpenoid and Steroid Metabolites from a Deep-Water Alaska Sponge Inhibit Wnt/β-Catenin Signaling in Colon Cancer Cells
The Wnt/β-catenin signaling pathway is known to play critical roles in a wide range of cellular processes: cell proliferation, differentiation, migration and embryonic development. Importantly, dysregulation of this pathway is tightly associated with pathogenesis in most human cancers. Therefore, th...
Published in: | Marine Drugs |
---|---|
Main Authors: | , , , , , , , , |
Format: | Text |
Language: | English |
Published: |
Multidisciplinary Digital Publishing Institute
2018
|
Subjects: | |
Online Access: | https://doi.org/10.3390/md16090297 |
id |
ftmdpi:oai:mdpi.com:/1660-3397/16/9/297/ |
---|---|
record_format |
openpolar |
spelling |
ftmdpi:oai:mdpi.com:/1660-3397/16/9/297/ 2023-08-20T04:10:23+02:00 Sesterterpenoid and Steroid Metabolites from a Deep-Water Alaska Sponge Inhibit Wnt/β-Catenin Signaling in Colon Cancer Cells Hyun Bong Park Nguyen Quoc Tuan Joonseok Oh Younglim Son Mark T. Hamann Robert Stone Michelle Kelly Sangtaek Oh MinKyun Na agris 2018-08-27 application/pdf https://doi.org/10.3390/md16090297 EN eng Multidisciplinary Digital Publishing Institute https://dx.doi.org/10.3390/md16090297 https://creativecommons.org/licenses/by/4.0/ Marine Drugs; Volume 16; Issue 9; Pages: 297 natural products marine sponge sesterterpenoid steroid colorectal cancer Wnt β-catenin Alaska Text 2018 ftmdpi https://doi.org/10.3390/md16090297 2023-07-31T21:41:46Z The Wnt/β-catenin signaling pathway is known to play critical roles in a wide range of cellular processes: cell proliferation, differentiation, migration and embryonic development. Importantly, dysregulation of this pathway is tightly associated with pathogenesis in most human cancers. Therefore, the Wnt/β-catenin pathway has emerged as a promising target in anticancer drug screening programs. In the present study, we have isolated three previously unreported metabolites from an undescribed sponge, a species of Monanchora (Order Poecilosclerida, Family Crambidae), closely related to the northeastern Pacific species Monanchora pulchra, collected from deep waters off the Aleutian Islands of Alaska. Through an assortment of NMR, MS, ECD, computational chemical shifts calculation, and DP4, chemical structures of these metabolites have been characterized as spirocyclic ring-containing sesterterpenoid (1) and cholestane-type steroidal analogues (2 and 3). These compounds exhibited the inhibition of β-catenin response transcription (CRT) through the promotion of β-catenin degradation, which was in part implicated in the antiproliferative activity against two CRT-positive colon cancer cell lines. Text Alaska Aleutian Islands MDPI Open Access Publishing Pacific Marine Drugs 16 9 297 |
institution |
Open Polar |
collection |
MDPI Open Access Publishing |
op_collection_id |
ftmdpi |
language |
English |
topic |
natural products marine sponge sesterterpenoid steroid colorectal cancer Wnt β-catenin Alaska |
spellingShingle |
natural products marine sponge sesterterpenoid steroid colorectal cancer Wnt β-catenin Alaska Hyun Bong Park Nguyen Quoc Tuan Joonseok Oh Younglim Son Mark T. Hamann Robert Stone Michelle Kelly Sangtaek Oh MinKyun Na Sesterterpenoid and Steroid Metabolites from a Deep-Water Alaska Sponge Inhibit Wnt/β-Catenin Signaling in Colon Cancer Cells |
topic_facet |
natural products marine sponge sesterterpenoid steroid colorectal cancer Wnt β-catenin Alaska |
description |
The Wnt/β-catenin signaling pathway is known to play critical roles in a wide range of cellular processes: cell proliferation, differentiation, migration and embryonic development. Importantly, dysregulation of this pathway is tightly associated with pathogenesis in most human cancers. Therefore, the Wnt/β-catenin pathway has emerged as a promising target in anticancer drug screening programs. In the present study, we have isolated three previously unreported metabolites from an undescribed sponge, a species of Monanchora (Order Poecilosclerida, Family Crambidae), closely related to the northeastern Pacific species Monanchora pulchra, collected from deep waters off the Aleutian Islands of Alaska. Through an assortment of NMR, MS, ECD, computational chemical shifts calculation, and DP4, chemical structures of these metabolites have been characterized as spirocyclic ring-containing sesterterpenoid (1) and cholestane-type steroidal analogues (2 and 3). These compounds exhibited the inhibition of β-catenin response transcription (CRT) through the promotion of β-catenin degradation, which was in part implicated in the antiproliferative activity against two CRT-positive colon cancer cell lines. |
format |
Text |
author |
Hyun Bong Park Nguyen Quoc Tuan Joonseok Oh Younglim Son Mark T. Hamann Robert Stone Michelle Kelly Sangtaek Oh MinKyun Na |
author_facet |
Hyun Bong Park Nguyen Quoc Tuan Joonseok Oh Younglim Son Mark T. Hamann Robert Stone Michelle Kelly Sangtaek Oh MinKyun Na |
author_sort |
Hyun Bong Park |
title |
Sesterterpenoid and Steroid Metabolites from a Deep-Water Alaska Sponge Inhibit Wnt/β-Catenin Signaling in Colon Cancer Cells |
title_short |
Sesterterpenoid and Steroid Metabolites from a Deep-Water Alaska Sponge Inhibit Wnt/β-Catenin Signaling in Colon Cancer Cells |
title_full |
Sesterterpenoid and Steroid Metabolites from a Deep-Water Alaska Sponge Inhibit Wnt/β-Catenin Signaling in Colon Cancer Cells |
title_fullStr |
Sesterterpenoid and Steroid Metabolites from a Deep-Water Alaska Sponge Inhibit Wnt/β-Catenin Signaling in Colon Cancer Cells |
title_full_unstemmed |
Sesterterpenoid and Steroid Metabolites from a Deep-Water Alaska Sponge Inhibit Wnt/β-Catenin Signaling in Colon Cancer Cells |
title_sort |
sesterterpenoid and steroid metabolites from a deep-water alaska sponge inhibit wnt/β-catenin signaling in colon cancer cells |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2018 |
url |
https://doi.org/10.3390/md16090297 |
op_coverage |
agris |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Alaska Aleutian Islands |
genre_facet |
Alaska Aleutian Islands |
op_source |
Marine Drugs; Volume 16; Issue 9; Pages: 297 |
op_relation |
https://dx.doi.org/10.3390/md16090297 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/md16090297 |
container_title |
Marine Drugs |
container_volume |
16 |
container_issue |
9 |
container_start_page |
297 |
_version_ |
1774724560151642112 |