Secondary Metabolites from Polar Organisms

• Published in: Marine Drugs
• Main Authors: Yuan Tian, Yan-Ling Li, Feng-Chun Zhao
• Format: Text
• Language: English
• Published: Multidisciplinary Digital Publishing Institute 2017
• Subjects: natural products; secondary metabolism; structure elucidation; biological activity; biosynthesis; chemical synthesis; Antarctic; Arctic; The Antarctic; Antarc*
• Online Access: https://doi.org/10.3390/md15030028

Polar organisms have been found to develop unique defences against the extreme environment environment, leading to the biosynthesis of novel molecules with diverse bioactivities. This review covers the 219 novel natural products described since 2001, from the Arctic and the Antarctic microoganisms, lichen, moss and marine faunas. The structures of the new compounds and details of the source organism, along with any relevant biological activities are presented. Where reported, synthetic and biosynthetic studies on the polar metabolites have also been included.