Eutypenoids A–C: Novel Pimarane Diterpenoids from the Arctic Fungus Eutypella sp. D-1

• Published in: Marine Drugs
• Main Authors: Liu-Qiang Zhang, Xiao-Chong Chen, Zhao-Qiang Chen, Gui-Min Wang, Shi-Guo Zhu, Yi-Fu Yang, Kai-Xian Chen, Xiao-Yu Liu, Yi-Ming Li
• Format: Text
• Language: English
• Published: Multidisciplinary Digital Publishing Institute 2016
• Subjects: eutypenoid; novel pimarane diterpenes; Eutypella; Arctic fungi; immunosuppressive effect; Arctic
• Online Access: https://doi.org/10.3390/md14030044

Eutypenoids A–C (1–3), pimarane diterpenoid alkaloid and two ring A rearranged pimarane diterpenoids, were isolated from the culture of Eutypella sp. D-1 obtained from high-latitude soil of the Arctic. Their structures, including absolute configurations, were authenticated on the basis of the mass spectroscopy (MS), nuclear magnetic resonance (NMR), X-ray crystallography, and electronic circular dichroism (ECD) analysis. The immunosuppressive effects of eutypenoids A–C (1–3) were studied using a ConA-induced splenocyte proliferation model, which suggested that 2 exhibited potent immunosuppressive activities.