A Phospholipid-Protein Complex from Krill with Antioxidative and Immunomodulating Properties Reduced Plasma Triacylglycerol and Hepatic Lipogenesis in Rats
Dietary intake of marine omega-3 polyunsaturated fatty acids (n-3 PUFAs) can change the plasma profile from atherogenic to cardioprotective. In addition, there is growing evidence that proteins of marine origin may have health benefits. We investigated a phospholipid-protein complex (PPC) from krill...
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ftmdpi:oai:mdpi.com:/1660-3397/13/7/4375/ 2023-08-20T04:01:50+02:00 A Phospholipid-Protein Complex from Krill with Antioxidative and Immunomodulating Properties Reduced Plasma Triacylglycerol and Hepatic Lipogenesis in Rats Marie Ramsvik Bodil Bjørndal Inge Bruheim Pavol Bohov Rolf Berge agris 2015-07-16 application/pdf https://doi.org/10.3390/md13074375 EN eng Multidisciplinary Digital Publishing Institute https://dx.doi.org/10.3390/md13074375 https://creativecommons.org/licenses/by/4.0/ Marine Drugs; Volume 13; Issue 7; Pages: 4375-4397 Antarctic krill lipogenesis plasma lipids inflammation antioxidant capacity omega-3 polyunsaturated fatty acids cholesterol lipid lowering Text 2015 ftmdpi https://doi.org/10.3390/md13074375 2023-07-31T20:45:05Z Dietary intake of marine omega-3 polyunsaturated fatty acids (n-3 PUFAs) can change the plasma profile from atherogenic to cardioprotective. In addition, there is growing evidence that proteins of marine origin may have health benefits. We investigated a phospholipid-protein complex (PPC) from krill that is hypothesized to influence lipid metabolism, inflammation, and redox status. Male Wistar rats were fed a control diet (2% soy oil, 8% lard, 20% casein), or diets where corresponding amounts of casein and lard were replaced with PPC at 3%, 6%, or 11% (wt %), for four weeks. Dietary supplementation with PPC resulted in significantly lower levels of plasma triacylglycerols in the 11% PPC-fed group, probably due to reduced hepatic lipogenesis. Plasma cholesterol levels were also reduced at the highest dose of PPC. In addition, the plasma and liver content of n-3 PUFAs increased while n-6 PUFAs decreased. This was associated with increased total antioxidant capacity in plasma and increased liver gene expression of mitochondrial superoxide dismutase (Sod2). Finally, a reduced plasma level of the inflammatory mediator interleukin-2 (IL-2) was detected in the PPC-fed animals. The present data show that PPC has lipid-lowering effects in rats, and may modulate risk factors related to cardiovascular disease progression. Text Antarc* Antarctic Antarctic Krill MDPI Open Access Publishing Antarctic Marine Drugs 13 7 4375 4397 |
institution |
Open Polar |
collection |
MDPI Open Access Publishing |
op_collection_id |
ftmdpi |
language |
English |
topic |
Antarctic krill lipogenesis plasma lipids inflammation antioxidant capacity omega-3 polyunsaturated fatty acids cholesterol lipid lowering |
spellingShingle |
Antarctic krill lipogenesis plasma lipids inflammation antioxidant capacity omega-3 polyunsaturated fatty acids cholesterol lipid lowering Marie Ramsvik Bodil Bjørndal Inge Bruheim Pavol Bohov Rolf Berge A Phospholipid-Protein Complex from Krill with Antioxidative and Immunomodulating Properties Reduced Plasma Triacylglycerol and Hepatic Lipogenesis in Rats |
topic_facet |
Antarctic krill lipogenesis plasma lipids inflammation antioxidant capacity omega-3 polyunsaturated fatty acids cholesterol lipid lowering |
description |
Dietary intake of marine omega-3 polyunsaturated fatty acids (n-3 PUFAs) can change the plasma profile from atherogenic to cardioprotective. In addition, there is growing evidence that proteins of marine origin may have health benefits. We investigated a phospholipid-protein complex (PPC) from krill that is hypothesized to influence lipid metabolism, inflammation, and redox status. Male Wistar rats were fed a control diet (2% soy oil, 8% lard, 20% casein), or diets where corresponding amounts of casein and lard were replaced with PPC at 3%, 6%, or 11% (wt %), for four weeks. Dietary supplementation with PPC resulted in significantly lower levels of plasma triacylglycerols in the 11% PPC-fed group, probably due to reduced hepatic lipogenesis. Plasma cholesterol levels were also reduced at the highest dose of PPC. In addition, the plasma and liver content of n-3 PUFAs increased while n-6 PUFAs decreased. This was associated with increased total antioxidant capacity in plasma and increased liver gene expression of mitochondrial superoxide dismutase (Sod2). Finally, a reduced plasma level of the inflammatory mediator interleukin-2 (IL-2) was detected in the PPC-fed animals. The present data show that PPC has lipid-lowering effects in rats, and may modulate risk factors related to cardiovascular disease progression. |
format |
Text |
author |
Marie Ramsvik Bodil Bjørndal Inge Bruheim Pavol Bohov Rolf Berge |
author_facet |
Marie Ramsvik Bodil Bjørndal Inge Bruheim Pavol Bohov Rolf Berge |
author_sort |
Marie Ramsvik |
title |
A Phospholipid-Protein Complex from Krill with Antioxidative and Immunomodulating Properties Reduced Plasma Triacylglycerol and Hepatic Lipogenesis in Rats |
title_short |
A Phospholipid-Protein Complex from Krill with Antioxidative and Immunomodulating Properties Reduced Plasma Triacylglycerol and Hepatic Lipogenesis in Rats |
title_full |
A Phospholipid-Protein Complex from Krill with Antioxidative and Immunomodulating Properties Reduced Plasma Triacylglycerol and Hepatic Lipogenesis in Rats |
title_fullStr |
A Phospholipid-Protein Complex from Krill with Antioxidative and Immunomodulating Properties Reduced Plasma Triacylglycerol and Hepatic Lipogenesis in Rats |
title_full_unstemmed |
A Phospholipid-Protein Complex from Krill with Antioxidative and Immunomodulating Properties Reduced Plasma Triacylglycerol and Hepatic Lipogenesis in Rats |
title_sort |
phospholipid-protein complex from krill with antioxidative and immunomodulating properties reduced plasma triacylglycerol and hepatic lipogenesis in rats |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2015 |
url |
https://doi.org/10.3390/md13074375 |
op_coverage |
agris |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic Antarctic Krill |
genre_facet |
Antarc* Antarctic Antarctic Krill |
op_source |
Marine Drugs; Volume 13; Issue 7; Pages: 4375-4397 |
op_relation |
https://dx.doi.org/10.3390/md13074375 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/md13074375 |
container_title |
Marine Drugs |
container_volume |
13 |
container_issue |
7 |
container_start_page |
4375 |
op_container_end_page |
4397 |
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1774712209285316608 |