Antifreeze Peptides and Glycopeptides, and Their Derivatives: Potential Uses in Biotechnology
Antifreeze proteins (AFPs) and glycoproteins (AFGPs), collectively called AF(G)Ps, constitute a diverse class of proteins found in various Arctic and Antarctic fish, as well as in amphibians, plants, and insects. These compounds possess the ability to inhibit the formation of ice and are therefore e...
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ftmdpi:oai:mdpi.com:/1660-3397/11/6/2013/ 2023-08-20T04:00:37+02:00 Antifreeze Peptides and Glycopeptides, and Their Derivatives: Potential Uses in Biotechnology Jeong Bang Jun Lee Ravichandran Murugan Sung Lee Hackwon Do Hye Koh Hye-Eun Shim Hyun-Cheol Kim Hak Kim agris 2013-06-10 application/pdf https://doi.org/10.3390/md11062013 EN eng Multidisciplinary Digital Publishing Institute https://dx.doi.org/10.3390/md11062013 https://creativecommons.org/licenses/by/3.0/ Marine Drugs; Volume 11; Issue 6; Pages: 2013-2041 antifreeze glycopeptide antifreeze protein recrystallization inhibition thermal hysteresis Text 2013 ftmdpi https://doi.org/10.3390/md11062013 2023-07-31T20:32:51Z Antifreeze proteins (AFPs) and glycoproteins (AFGPs), collectively called AF(G)Ps, constitute a diverse class of proteins found in various Arctic and Antarctic fish, as well as in amphibians, plants, and insects. These compounds possess the ability to inhibit the formation of ice and are therefore essential to the survival of many marine teleost fishes that routinely encounter sub-zero temperatures. Owing to this property, AF(G)Ps have potential applications in many areas such as storage of cells or tissues at low temperature, ice slurries for refrigeration systems, and food storage. In contrast to AFGPs, which are composed of repeated tripeptide units (Ala-Ala-Thr)n with minor sequence variations, AFPs possess very different primary, secondary, and tertiary structures. The isolation and purification of AFGPs is laborious, costly, and often results in mixtures, making characterization difficult. Recent structural investigations into the mechanism by which linear and cyclic AFGPs inhibit ice crystallization have led to significant progress toward the synthesis and assessment of several synthetic mimics of AFGPs. This review article will summarize synthetic AFGP mimics as well as current challenges in designing compounds capable of mimicking AFGPs. It will also cover our recent efforts in exploring whether peptoid mimics can serve as structural and functional mimics of native AFGPs. Text Antarc* Antarctic Arctic MDPI Open Access Publishing Antarctic Arctic Marine Drugs 11 6 2013 2041 |
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Open Polar |
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MDPI Open Access Publishing |
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ftmdpi |
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English |
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antifreeze glycopeptide antifreeze protein recrystallization inhibition thermal hysteresis |
spellingShingle |
antifreeze glycopeptide antifreeze protein recrystallization inhibition thermal hysteresis Jeong Bang Jun Lee Ravichandran Murugan Sung Lee Hackwon Do Hye Koh Hye-Eun Shim Hyun-Cheol Kim Hak Kim Antifreeze Peptides and Glycopeptides, and Their Derivatives: Potential Uses in Biotechnology |
topic_facet |
antifreeze glycopeptide antifreeze protein recrystallization inhibition thermal hysteresis |
description |
Antifreeze proteins (AFPs) and glycoproteins (AFGPs), collectively called AF(G)Ps, constitute a diverse class of proteins found in various Arctic and Antarctic fish, as well as in amphibians, plants, and insects. These compounds possess the ability to inhibit the formation of ice and are therefore essential to the survival of many marine teleost fishes that routinely encounter sub-zero temperatures. Owing to this property, AF(G)Ps have potential applications in many areas such as storage of cells or tissues at low temperature, ice slurries for refrigeration systems, and food storage. In contrast to AFGPs, which are composed of repeated tripeptide units (Ala-Ala-Thr)n with minor sequence variations, AFPs possess very different primary, secondary, and tertiary structures. The isolation and purification of AFGPs is laborious, costly, and often results in mixtures, making characterization difficult. Recent structural investigations into the mechanism by which linear and cyclic AFGPs inhibit ice crystallization have led to significant progress toward the synthesis and assessment of several synthetic mimics of AFGPs. This review article will summarize synthetic AFGP mimics as well as current challenges in designing compounds capable of mimicking AFGPs. It will also cover our recent efforts in exploring whether peptoid mimics can serve as structural and functional mimics of native AFGPs. |
format |
Text |
author |
Jeong Bang Jun Lee Ravichandran Murugan Sung Lee Hackwon Do Hye Koh Hye-Eun Shim Hyun-Cheol Kim Hak Kim |
author_facet |
Jeong Bang Jun Lee Ravichandran Murugan Sung Lee Hackwon Do Hye Koh Hye-Eun Shim Hyun-Cheol Kim Hak Kim |
author_sort |
Jeong Bang |
title |
Antifreeze Peptides and Glycopeptides, and Their Derivatives: Potential Uses in Biotechnology |
title_short |
Antifreeze Peptides and Glycopeptides, and Their Derivatives: Potential Uses in Biotechnology |
title_full |
Antifreeze Peptides and Glycopeptides, and Their Derivatives: Potential Uses in Biotechnology |
title_fullStr |
Antifreeze Peptides and Glycopeptides, and Their Derivatives: Potential Uses in Biotechnology |
title_full_unstemmed |
Antifreeze Peptides and Glycopeptides, and Their Derivatives: Potential Uses in Biotechnology |
title_sort |
antifreeze peptides and glycopeptides, and their derivatives: potential uses in biotechnology |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2013 |
url |
https://doi.org/10.3390/md11062013 |
op_coverage |
agris |
geographic |
Antarctic Arctic |
geographic_facet |
Antarctic Arctic |
genre |
Antarc* Antarctic Arctic |
genre_facet |
Antarc* Antarctic Arctic |
op_source |
Marine Drugs; Volume 11; Issue 6; Pages: 2013-2041 |
op_relation |
https://dx.doi.org/10.3390/md11062013 |
op_rights |
https://creativecommons.org/licenses/by/3.0/ |
op_doi |
https://doi.org/10.3390/md11062013 |
container_title |
Marine Drugs |
container_volume |
11 |
container_issue |
6 |
container_start_page |
2013 |
op_container_end_page |
2041 |
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1774719275700846592 |