Biological Activities of Ethanolic Extracts from Deep-Sea Antarctic Marine Sponges
We report on the screening of ethanolic extracts from 33 deep-sea Antarctic marine sponges for different biological activities. We monitored hemolysis, inhibition of acetylcholinesterase, cytotoxicity towards normal and transformed cells and growth inhibition of laboratory, commensal and clinically...
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ftmdpi:oai:mdpi.com:/1660-3397/11/4/1126/ 2023-08-20T04:02:31+02:00 Biological Activities of Ethanolic Extracts from Deep-Sea Antarctic Marine Sponges Tom Turk Jerneja Avguštin Urška Batista Gašper Strugar Rok Kosmina Sandra Čivović Dorte Janussen Silke Kauferstein Dietrich Mebs Kristina Sepčić agris 2013-04-02 application/pdf https://doi.org/10.3390/md11041126 EN eng Multidisciplinary Digital Publishing Institute https://dx.doi.org/10.3390/md11041126 https://creativecommons.org/licenses/by/3.0/ Marine Drugs; Volume 11; Issue 4; Pages: 1126-1139 Antarctic marine sponges hemolysis antibacterial activity acetylcholinesterase inhibition cytotoxicity Text 2013 ftmdpi https://doi.org/10.3390/md11041126 2023-07-31T20:32:06Z We report on the screening of ethanolic extracts from 33 deep-sea Antarctic marine sponges for different biological activities. We monitored hemolysis, inhibition of acetylcholinesterase, cytotoxicity towards normal and transformed cells and growth inhibition of laboratory, commensal and clinically and ecologically relevant bacteria. The most prominent activities were associated with the extracts from sponges belonging to the genus Latrunculia, which show all of these activities. While most of these activities are associated to already known secondary metabolites, the extremely strong acetylcholinesterase inhibitory potential appears to be related to a compound unknown to date. Extracts from Tetilla leptoderma, Bathydorus cf. spinosus, Xestospongia sp., Rossella sp., Rossella cf. racovitzae and Halichondria osculum were hemolytic, with the last two also showing moderate cytotoxic potential. The antibacterial tests showed significantly greater activities of the extracts of these Antarctic sponges towards ecologically relevant bacteria from sea water and from Arctic ice. This indicates their ecological relevance for inhibition of bacterial microfouling. Text Antarc* Antarctic Arctic MDPI Open Access Publishing Antarctic Arctic Marine Drugs 11 12 1126 1139 |
institution |
Open Polar |
collection |
MDPI Open Access Publishing |
op_collection_id |
ftmdpi |
language |
English |
topic |
Antarctic marine sponges hemolysis antibacterial activity acetylcholinesterase inhibition cytotoxicity |
spellingShingle |
Antarctic marine sponges hemolysis antibacterial activity acetylcholinesterase inhibition cytotoxicity Tom Turk Jerneja Avguštin Urška Batista Gašper Strugar Rok Kosmina Sandra Čivović Dorte Janussen Silke Kauferstein Dietrich Mebs Kristina Sepčić Biological Activities of Ethanolic Extracts from Deep-Sea Antarctic Marine Sponges |
topic_facet |
Antarctic marine sponges hemolysis antibacterial activity acetylcholinesterase inhibition cytotoxicity |
description |
We report on the screening of ethanolic extracts from 33 deep-sea Antarctic marine sponges for different biological activities. We monitored hemolysis, inhibition of acetylcholinesterase, cytotoxicity towards normal and transformed cells and growth inhibition of laboratory, commensal and clinically and ecologically relevant bacteria. The most prominent activities were associated with the extracts from sponges belonging to the genus Latrunculia, which show all of these activities. While most of these activities are associated to already known secondary metabolites, the extremely strong acetylcholinesterase inhibitory potential appears to be related to a compound unknown to date. Extracts from Tetilla leptoderma, Bathydorus cf. spinosus, Xestospongia sp., Rossella sp., Rossella cf. racovitzae and Halichondria osculum were hemolytic, with the last two also showing moderate cytotoxic potential. The antibacterial tests showed significantly greater activities of the extracts of these Antarctic sponges towards ecologically relevant bacteria from sea water and from Arctic ice. This indicates their ecological relevance for inhibition of bacterial microfouling. |
format |
Text |
author |
Tom Turk Jerneja Avguštin Urška Batista Gašper Strugar Rok Kosmina Sandra Čivović Dorte Janussen Silke Kauferstein Dietrich Mebs Kristina Sepčić |
author_facet |
Tom Turk Jerneja Avguštin Urška Batista Gašper Strugar Rok Kosmina Sandra Čivović Dorte Janussen Silke Kauferstein Dietrich Mebs Kristina Sepčić |
author_sort |
Tom Turk |
title |
Biological Activities of Ethanolic Extracts from Deep-Sea Antarctic Marine Sponges |
title_short |
Biological Activities of Ethanolic Extracts from Deep-Sea Antarctic Marine Sponges |
title_full |
Biological Activities of Ethanolic Extracts from Deep-Sea Antarctic Marine Sponges |
title_fullStr |
Biological Activities of Ethanolic Extracts from Deep-Sea Antarctic Marine Sponges |
title_full_unstemmed |
Biological Activities of Ethanolic Extracts from Deep-Sea Antarctic Marine Sponges |
title_sort |
biological activities of ethanolic extracts from deep-sea antarctic marine sponges |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2013 |
url |
https://doi.org/10.3390/md11041126 |
op_coverage |
agris |
geographic |
Antarctic Arctic |
geographic_facet |
Antarctic Arctic |
genre |
Antarc* Antarctic Arctic |
genre_facet |
Antarc* Antarctic Arctic |
op_source |
Marine Drugs; Volume 11; Issue 4; Pages: 1126-1139 |
op_relation |
https://dx.doi.org/10.3390/md11041126 |
op_rights |
https://creativecommons.org/licenses/by/3.0/ |
op_doi |
https://doi.org/10.3390/md11041126 |
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Marine Drugs |
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11 |
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12 |
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1126 |
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1139 |
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1774712994685517824 |