Novel One-Pot Green Synthesis of Indolizines Biocatalysed by Candida antarctica Lipases

• Published in: Marine Drugs
• Main Authors: Rodica Dinica, Bianca Furdui, Ioana Ghinea, Gabriela Bahrim, Simon Bonte, Martine Demeunynck
• Format: Text
• Language: English
• Published: Multidisciplinary Digital Publishing Institute 2013
• Subjects: indolizine; Candida antarctica lipase; one-pot reaction; cycloaddition; ylide; Antarc*; Antarctica
• Online Access: https://doi.org/10.3390/md11020431

Marine microorganisms are of considerable interest as a promising source of enzymes with unsuspected potentials as catalysts for chemical synthesis. We describe here an efficient method for one-pot indolizine synthesis that has been developed using lipase A and lipase B from Candida antarctica as biocatalysts. As showed by HPLC/MS analysis, the yield in indolizines was higher in the presence of the biocatalyst than in absence of enzyme. Lipase A, from Candida antarctica, showed high catalytic activity and selectivity for the cycloaddition reactions. When the reactions were performed under ultrasound irradiation, the Candida antarctica lipase catalyzed reactions yielded pure indolozines, in good yields and in very short time.