Novel One-Pot Green Synthesis of Indolizines Biocatalysed by Candida antarctica Lipases
Marine microorganisms are of considerable interest as a promising source of enzymes with unsuspected potentials as catalysts for chemical synthesis. We describe here an efficient method for one-pot indolizine synthesis that has been developed using lipase A and lipase B from Candida antarctica as bi...
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Online Access: | https://doi.org/10.3390/md11020431 |
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ftmdpi:oai:mdpi.com:/1660-3397/11/2/431/ 2023-08-20T04:02:31+02:00 Novel One-Pot Green Synthesis of Indolizines Biocatalysed by Candida antarctica Lipases Rodica Dinica Bianca Furdui Ioana Ghinea Gabriela Bahrim Simon Bonte Martine Demeunynck agris 2013-02-06 application/pdf https://doi.org/10.3390/md11020431 EN eng Multidisciplinary Digital Publishing Institute https://dx.doi.org/10.3390/md11020431 https://creativecommons.org/licenses/by/3.0/ Marine Drugs; Volume 11; Issue 2; Pages: 431-439 indolizine Candida antarctica lipase one-pot reaction cycloaddition ylide Text 2013 ftmdpi https://doi.org/10.3390/md11020431 2023-07-31T20:31:33Z Marine microorganisms are of considerable interest as a promising source of enzymes with unsuspected potentials as catalysts for chemical synthesis. We describe here an efficient method for one-pot indolizine synthesis that has been developed using lipase A and lipase B from Candida antarctica as biocatalysts. As showed by HPLC/MS analysis, the yield in indolizines was higher in the presence of the biocatalyst than in absence of enzyme. Lipase A, from Candida antarctica, showed high catalytic activity and selectivity for the cycloaddition reactions. When the reactions were performed under ultrasound irradiation, the Candida antarctica lipase catalyzed reactions yielded pure indolozines, in good yields and in very short time. Text Antarc* Antarctica MDPI Open Access Publishing Marine Drugs 11 12 431 439 |
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Open Polar |
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MDPI Open Access Publishing |
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ftmdpi |
language |
English |
topic |
indolizine Candida antarctica lipase one-pot reaction cycloaddition ylide |
spellingShingle |
indolizine Candida antarctica lipase one-pot reaction cycloaddition ylide Rodica Dinica Bianca Furdui Ioana Ghinea Gabriela Bahrim Simon Bonte Martine Demeunynck Novel One-Pot Green Synthesis of Indolizines Biocatalysed by Candida antarctica Lipases |
topic_facet |
indolizine Candida antarctica lipase one-pot reaction cycloaddition ylide |
description |
Marine microorganisms are of considerable interest as a promising source of enzymes with unsuspected potentials as catalysts for chemical synthesis. We describe here an efficient method for one-pot indolizine synthesis that has been developed using lipase A and lipase B from Candida antarctica as biocatalysts. As showed by HPLC/MS analysis, the yield in indolizines was higher in the presence of the biocatalyst than in absence of enzyme. Lipase A, from Candida antarctica, showed high catalytic activity and selectivity for the cycloaddition reactions. When the reactions were performed under ultrasound irradiation, the Candida antarctica lipase catalyzed reactions yielded pure indolozines, in good yields and in very short time. |
format |
Text |
author |
Rodica Dinica Bianca Furdui Ioana Ghinea Gabriela Bahrim Simon Bonte Martine Demeunynck |
author_facet |
Rodica Dinica Bianca Furdui Ioana Ghinea Gabriela Bahrim Simon Bonte Martine Demeunynck |
author_sort |
Rodica Dinica |
title |
Novel One-Pot Green Synthesis of Indolizines Biocatalysed by Candida antarctica Lipases |
title_short |
Novel One-Pot Green Synthesis of Indolizines Biocatalysed by Candida antarctica Lipases |
title_full |
Novel One-Pot Green Synthesis of Indolizines Biocatalysed by Candida antarctica Lipases |
title_fullStr |
Novel One-Pot Green Synthesis of Indolizines Biocatalysed by Candida antarctica Lipases |
title_full_unstemmed |
Novel One-Pot Green Synthesis of Indolizines Biocatalysed by Candida antarctica Lipases |
title_sort |
novel one-pot green synthesis of indolizines biocatalysed by candida antarctica lipases |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2013 |
url |
https://doi.org/10.3390/md11020431 |
op_coverage |
agris |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
Marine Drugs; Volume 11; Issue 2; Pages: 431-439 |
op_relation |
https://dx.doi.org/10.3390/md11020431 |
op_rights |
https://creativecommons.org/licenses/by/3.0/ |
op_doi |
https://doi.org/10.3390/md11020431 |
container_title |
Marine Drugs |
container_volume |
11 |
container_issue |
12 |
container_start_page |
431 |
op_container_end_page |
439 |
_version_ |
1774712994515648512 |