Antitumor Properties of Matrikines of Different Origins: Prospects and Problems of Their Application
Matrikines (MKs) can be a rich source of functional nutrition components and additional therapy, thereby contributing to human health care and reducing the risk of developing serious diseases, including cancer. Currently, functionally active MKs as products of enzymatic transformation by matrix meta...
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ftmdpi:oai:mdpi.com:/1422-0067/24/11/9502/ 2023-08-20T04:09:26+02:00 Antitumor Properties of Matrikines of Different Origins: Prospects and Problems of Their Application Aleksandr Popov Emma Kozlovskaya Tatyana Rutckova Olga Styshova Aleksey Vakhrushev Elena Kupera Ludmila Tekutyeva agris 2023-05-30 application/pdf https://doi.org/10.3390/ijms24119502 EN eng Multidisciplinary Digital Publishing Institute Molecular Oncology https://dx.doi.org/10.3390/ijms24119502 https://creativecommons.org/licenses/by/4.0/ International Journal of Molecular Sciences; Volume 24; Issue 11; Pages: 9502 matrikines (MKs) collagen antitumor activity matrix metalloproteinases (MMPs) echinoderms Text 2023 ftmdpi https://doi.org/10.3390/ijms24119502 2023-08-01T10:17:20Z Matrikines (MKs) can be a rich source of functional nutrition components and additional therapy, thereby contributing to human health care and reducing the risk of developing serious diseases, including cancer. Currently, functionally active MKs as products of enzymatic transformation by matrix metalloproteinases (MMPs) are used for various biomedical purposes. Due to the absence of toxic side effects, low species specificity, relatively small size, and presence of various targets at the cell membranes, MKs often exhibit antitumor properties and, therefore, are promising agents for antitumor combination therapy. This review summarizes and analyzes the current data on the antitumor activity of MKs of different origins, discusses the problems and prospects for their therapeutic use, and evaluates the experimental results of studying the antitumor properties of MKs from different echinoderm species generated with the help of a complex of proteolytic enzymes from red king crab Paralithodes camtschatica. Special attention is paid to the analysis of possible mechanisms of the antitumor action of various functionally active MKs, products of the enzymatic activity of various MMPs, and the existing problems for their use in antitumor therapy. Text Red king crab MDPI Open Access Publishing International Journal of Molecular Sciences 24 11 9502 |
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matrikines (MKs) collagen antitumor activity matrix metalloproteinases (MMPs) echinoderms |
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matrikines (MKs) collagen antitumor activity matrix metalloproteinases (MMPs) echinoderms Aleksandr Popov Emma Kozlovskaya Tatyana Rutckova Olga Styshova Aleksey Vakhrushev Elena Kupera Ludmila Tekutyeva Antitumor Properties of Matrikines of Different Origins: Prospects and Problems of Their Application |
topic_facet |
matrikines (MKs) collagen antitumor activity matrix metalloproteinases (MMPs) echinoderms |
description |
Matrikines (MKs) can be a rich source of functional nutrition components and additional therapy, thereby contributing to human health care and reducing the risk of developing serious diseases, including cancer. Currently, functionally active MKs as products of enzymatic transformation by matrix metalloproteinases (MMPs) are used for various biomedical purposes. Due to the absence of toxic side effects, low species specificity, relatively small size, and presence of various targets at the cell membranes, MKs often exhibit antitumor properties and, therefore, are promising agents for antitumor combination therapy. This review summarizes and analyzes the current data on the antitumor activity of MKs of different origins, discusses the problems and prospects for their therapeutic use, and evaluates the experimental results of studying the antitumor properties of MKs from different echinoderm species generated with the help of a complex of proteolytic enzymes from red king crab Paralithodes camtschatica. Special attention is paid to the analysis of possible mechanisms of the antitumor action of various functionally active MKs, products of the enzymatic activity of various MMPs, and the existing problems for their use in antitumor therapy. |
format |
Text |
author |
Aleksandr Popov Emma Kozlovskaya Tatyana Rutckova Olga Styshova Aleksey Vakhrushev Elena Kupera Ludmila Tekutyeva |
author_facet |
Aleksandr Popov Emma Kozlovskaya Tatyana Rutckova Olga Styshova Aleksey Vakhrushev Elena Kupera Ludmila Tekutyeva |
author_sort |
Aleksandr Popov |
title |
Antitumor Properties of Matrikines of Different Origins: Prospects and Problems of Their Application |
title_short |
Antitumor Properties of Matrikines of Different Origins: Prospects and Problems of Their Application |
title_full |
Antitumor Properties of Matrikines of Different Origins: Prospects and Problems of Their Application |
title_fullStr |
Antitumor Properties of Matrikines of Different Origins: Prospects and Problems of Their Application |
title_full_unstemmed |
Antitumor Properties of Matrikines of Different Origins: Prospects and Problems of Their Application |
title_sort |
antitumor properties of matrikines of different origins: prospects and problems of their application |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2023 |
url |
https://doi.org/10.3390/ijms24119502 |
op_coverage |
agris |
genre |
Red king crab |
genre_facet |
Red king crab |
op_source |
International Journal of Molecular Sciences; Volume 24; Issue 11; Pages: 9502 |
op_relation |
Molecular Oncology https://dx.doi.org/10.3390/ijms24119502 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/ijms24119502 |
container_title |
International Journal of Molecular Sciences |
container_volume |
24 |
container_issue |
11 |
container_start_page |
9502 |
_version_ |
1774722394657652736 |