Amphiphilic Pentablock Copolymers Prepared from Pluronic and ε-Caprolactone by Enzymatic Ring Opening Polymerization
Amphiphilic copolymers are appealing materials because of their interesting architecture and tunable properties. In view of their application in the biomedical field, the preparation of these materials should avoid the use of toxic compounds as catalysts. Therefore, enzymatic catalysis is a suitable...
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ftmdpi:oai:mdpi.com:/1422-0067/23/3/1390/ 2023-08-20T04:01:50+02:00 Amphiphilic Pentablock Copolymers Prepared from Pluronic and ε-Caprolactone by Enzymatic Ring Opening Polymerization Ahmed Abd El-Fattah Elizabeth Grillo Fernandes Federica Chiellini Emo Chiellini agris 2022-01-26 application/pdf https://doi.org/10.3390/ijms23031390 EN eng Multidisciplinary Digital Publishing Institute Macromolecules https://dx.doi.org/10.3390/ijms23031390 https://creativecommons.org/licenses/by/4.0/ International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1390 Candida antarctica lipase B enzyme ring-opening polymerization ε-caprolactone Pluronic morphology Text 2022 ftmdpi https://doi.org/10.3390/ijms23031390 2023-08-01T03:57:30Z Amphiphilic copolymers are appealing materials because of their interesting architecture and tunable properties. In view of their application in the biomedical field, the preparation of these materials should avoid the use of toxic compounds as catalysts. Therefore, enzymatic catalysis is a suitable alternative to common synthetic routes. Pentablock copolymers (CUC) were synthesized with high yields by ring-opening polymerization of ε-caprolactone (ε-CL) initiated by Pluronic (EPE) and catalyzed by Candida antarctica lipase B enzyme. The variables to study the structure–property relationship were EPEs’ molecular weight and molar ratios between ε-CL monomer and EPE macro-initiator (M/In). The obtained copolymers were chemically characterized, the molecular weight determined, and morphologies evaluated. The results suggest an interaction between the reaction time and M/In variables. There was a correlation between the differential scanning calorimetry data with those of X-ray diffraction (WAXD). The length of the central block of CUC copolymers may have an important role in the crystal formation. WAXD analyses indicated that a micro-phase separation takes place in all the prepared copolymers. Preliminary cytotoxicity experiments on the extracts of the polymer confirmed that these materials are nontoxic. Text Antarc* Antarctica MDPI Open Access Publishing International Journal of Molecular Sciences 23 3 1390 |
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Open Polar |
collection |
MDPI Open Access Publishing |
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ftmdpi |
language |
English |
topic |
Candida antarctica lipase B enzyme ring-opening polymerization ε-caprolactone Pluronic morphology |
spellingShingle |
Candida antarctica lipase B enzyme ring-opening polymerization ε-caprolactone Pluronic morphology Ahmed Abd El-Fattah Elizabeth Grillo Fernandes Federica Chiellini Emo Chiellini Amphiphilic Pentablock Copolymers Prepared from Pluronic and ε-Caprolactone by Enzymatic Ring Opening Polymerization |
topic_facet |
Candida antarctica lipase B enzyme ring-opening polymerization ε-caprolactone Pluronic morphology |
description |
Amphiphilic copolymers are appealing materials because of their interesting architecture and tunable properties. In view of their application in the biomedical field, the preparation of these materials should avoid the use of toxic compounds as catalysts. Therefore, enzymatic catalysis is a suitable alternative to common synthetic routes. Pentablock copolymers (CUC) were synthesized with high yields by ring-opening polymerization of ε-caprolactone (ε-CL) initiated by Pluronic (EPE) and catalyzed by Candida antarctica lipase B enzyme. The variables to study the structure–property relationship were EPEs’ molecular weight and molar ratios between ε-CL monomer and EPE macro-initiator (M/In). The obtained copolymers were chemically characterized, the molecular weight determined, and morphologies evaluated. The results suggest an interaction between the reaction time and M/In variables. There was a correlation between the differential scanning calorimetry data with those of X-ray diffraction (WAXD). The length of the central block of CUC copolymers may have an important role in the crystal formation. WAXD analyses indicated that a micro-phase separation takes place in all the prepared copolymers. Preliminary cytotoxicity experiments on the extracts of the polymer confirmed that these materials are nontoxic. |
format |
Text |
author |
Ahmed Abd El-Fattah Elizabeth Grillo Fernandes Federica Chiellini Emo Chiellini |
author_facet |
Ahmed Abd El-Fattah Elizabeth Grillo Fernandes Federica Chiellini Emo Chiellini |
author_sort |
Ahmed Abd El-Fattah |
title |
Amphiphilic Pentablock Copolymers Prepared from Pluronic and ε-Caprolactone by Enzymatic Ring Opening Polymerization |
title_short |
Amphiphilic Pentablock Copolymers Prepared from Pluronic and ε-Caprolactone by Enzymatic Ring Opening Polymerization |
title_full |
Amphiphilic Pentablock Copolymers Prepared from Pluronic and ε-Caprolactone by Enzymatic Ring Opening Polymerization |
title_fullStr |
Amphiphilic Pentablock Copolymers Prepared from Pluronic and ε-Caprolactone by Enzymatic Ring Opening Polymerization |
title_full_unstemmed |
Amphiphilic Pentablock Copolymers Prepared from Pluronic and ε-Caprolactone by Enzymatic Ring Opening Polymerization |
title_sort |
amphiphilic pentablock copolymers prepared from pluronic and ε-caprolactone by enzymatic ring opening polymerization |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2022 |
url |
https://doi.org/10.3390/ijms23031390 |
op_coverage |
agris |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1390 |
op_relation |
Macromolecules https://dx.doi.org/10.3390/ijms23031390 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/ijms23031390 |
container_title |
International Journal of Molecular Sciences |
container_volume |
23 |
container_issue |
3 |
container_start_page |
1390 |
_version_ |
1774725045564735488 |