Anti-Inflammatory Effects Exerted by 14-Methoxyalternate C from Antarctic Fungal Strain Pleosporales sp. SF-7343 via the Regulation of NF-κB and JAK2/STAT3 in HaCaT Human Keratinocytes
Atopic dermatitis (AD) is a chronic inflammatory skin disease with a profound negative impact on patients’ quality of life. Four known secondary fungal metabolites were found in the chemical study of the Antarctic fungus Pleosporales sp. SF-7343, including 14-methoxyalternate C (1), 5′-methoxy-6-met...
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ftmdpi:oai:mdpi.com:/1422-0067/23/23/14642/ 2023-08-20T04:02:23+02:00 Anti-Inflammatory Effects Exerted by 14-Methoxyalternate C from Antarctic Fungal Strain Pleosporales sp. SF-7343 via the Regulation of NF-κB and JAK2/STAT3 in HaCaT Human Keratinocytes Linsha Dong Thao Quyen Cao Zhiming Liu Nguyen Quoc Tuan Youn-Chul Kim Jae Hak Sohn Joung Han Yim Dong-Sung Lee Hyuncheol Oh agris 2022-11-24 application/pdf https://doi.org/10.3390/ijms232314642 EN eng Multidisciplinary Digital Publishing Institute Molecular Immunology https://dx.doi.org/10.3390/ijms232314642 https://creativecommons.org/licenses/by/4.0/ International Journal of Molecular Sciences; Volume 23; Issue 23; Pages: 14642 Antarctic fungi skin inflammation JAK2/STAT3 NF-κB HaCaT Text 2022 ftmdpi https://doi.org/10.3390/ijms232314642 2023-08-01T07:29:09Z Atopic dermatitis (AD) is a chronic inflammatory skin disease with a profound negative impact on patients’ quality of life. Four known secondary fungal metabolites were found in the chemical study of the Antarctic fungus Pleosporales sp. SF-7343, including 14-methoxyalternate C (1), 5′-methoxy-6-methyl-biphenyl-3,4,3′-triol (2), 3,8,10-trihydroxy-4-methoxy-6-methylbenzocoumarin (3), and alternariol monomethyl ether (4). Additionally, we identified the skin anti-inflammatory composition from the SF-7343 strain. Interleukin-8 and -6 Screening results showed that compound 1 inhibited IL-8 and IL-6 in tumor necrosis factor-α/interferon-γ stimulated HaCaT cells. Compound 1 showed inhibitory effects on MDC and RANTES. It also downregulated the expression of intercellular adhesion molecule-1 (ICAM-1) and upregulated the expression of involucrin. The results of the mechanistic study showed that compound 1 inhibited the nuclear translocation of nuclear factor-kappa B p65 and STAT3. In conclusion, this study demonstrates the potential of the Antarctic fungal strain SF-7343 as a bioactive resource to inhibit skin inflammation, such as AD. Text Antarc* Antarctic MDPI Open Access Publishing Antarctic The Antarctic International Journal of Molecular Sciences 23 23 14642 |
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English |
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Antarctic fungi skin inflammation JAK2/STAT3 NF-κB HaCaT |
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Antarctic fungi skin inflammation JAK2/STAT3 NF-κB HaCaT Linsha Dong Thao Quyen Cao Zhiming Liu Nguyen Quoc Tuan Youn-Chul Kim Jae Hak Sohn Joung Han Yim Dong-Sung Lee Hyuncheol Oh Anti-Inflammatory Effects Exerted by 14-Methoxyalternate C from Antarctic Fungal Strain Pleosporales sp. SF-7343 via the Regulation of NF-κB and JAK2/STAT3 in HaCaT Human Keratinocytes |
topic_facet |
Antarctic fungi skin inflammation JAK2/STAT3 NF-κB HaCaT |
description |
Atopic dermatitis (AD) is a chronic inflammatory skin disease with a profound negative impact on patients’ quality of life. Four known secondary fungal metabolites were found in the chemical study of the Antarctic fungus Pleosporales sp. SF-7343, including 14-methoxyalternate C (1), 5′-methoxy-6-methyl-biphenyl-3,4,3′-triol (2), 3,8,10-trihydroxy-4-methoxy-6-methylbenzocoumarin (3), and alternariol monomethyl ether (4). Additionally, we identified the skin anti-inflammatory composition from the SF-7343 strain. Interleukin-8 and -6 Screening results showed that compound 1 inhibited IL-8 and IL-6 in tumor necrosis factor-α/interferon-γ stimulated HaCaT cells. Compound 1 showed inhibitory effects on MDC and RANTES. It also downregulated the expression of intercellular adhesion molecule-1 (ICAM-1) and upregulated the expression of involucrin. The results of the mechanistic study showed that compound 1 inhibited the nuclear translocation of nuclear factor-kappa B p65 and STAT3. In conclusion, this study demonstrates the potential of the Antarctic fungal strain SF-7343 as a bioactive resource to inhibit skin inflammation, such as AD. |
format |
Text |
author |
Linsha Dong Thao Quyen Cao Zhiming Liu Nguyen Quoc Tuan Youn-Chul Kim Jae Hak Sohn Joung Han Yim Dong-Sung Lee Hyuncheol Oh |
author_facet |
Linsha Dong Thao Quyen Cao Zhiming Liu Nguyen Quoc Tuan Youn-Chul Kim Jae Hak Sohn Joung Han Yim Dong-Sung Lee Hyuncheol Oh |
author_sort |
Linsha Dong |
title |
Anti-Inflammatory Effects Exerted by 14-Methoxyalternate C from Antarctic Fungal Strain Pleosporales sp. SF-7343 via the Regulation of NF-κB and JAK2/STAT3 in HaCaT Human Keratinocytes |
title_short |
Anti-Inflammatory Effects Exerted by 14-Methoxyalternate C from Antarctic Fungal Strain Pleosporales sp. SF-7343 via the Regulation of NF-κB and JAK2/STAT3 in HaCaT Human Keratinocytes |
title_full |
Anti-Inflammatory Effects Exerted by 14-Methoxyalternate C from Antarctic Fungal Strain Pleosporales sp. SF-7343 via the Regulation of NF-κB and JAK2/STAT3 in HaCaT Human Keratinocytes |
title_fullStr |
Anti-Inflammatory Effects Exerted by 14-Methoxyalternate C from Antarctic Fungal Strain Pleosporales sp. SF-7343 via the Regulation of NF-κB and JAK2/STAT3 in HaCaT Human Keratinocytes |
title_full_unstemmed |
Anti-Inflammatory Effects Exerted by 14-Methoxyalternate C from Antarctic Fungal Strain Pleosporales sp. SF-7343 via the Regulation of NF-κB and JAK2/STAT3 in HaCaT Human Keratinocytes |
title_sort |
anti-inflammatory effects exerted by 14-methoxyalternate c from antarctic fungal strain pleosporales sp. sf-7343 via the regulation of nf-κb and jak2/stat3 in hacat human keratinocytes |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2022 |
url |
https://doi.org/10.3390/ijms232314642 |
op_coverage |
agris |
geographic |
Antarctic The Antarctic |
geographic_facet |
Antarctic The Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
International Journal of Molecular Sciences; Volume 23; Issue 23; Pages: 14642 |
op_relation |
Molecular Immunology https://dx.doi.org/10.3390/ijms232314642 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/ijms232314642 |
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International Journal of Molecular Sciences |
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23 |
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23 |
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14642 |
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1774712803189325824 |