The Role of Nonshivering Thermogenesis Genes on Leptin Levels Regulation in Residents of the Coldest Region of Siberia
Leptin plays an important role in thermoregulation and is possibly associated with the microevolutionary processes of human adaptation to a cold climate. In this study, based on the Yakut population (n = 281 individuals) living in the coldest region of Siberia (t°minimum −71.2 °C), we analyze the se...
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ftmdpi:oai:mdpi.com:/1422-0067/22/9/4657/ 2023-08-20T04:04:44+02:00 The Role of Nonshivering Thermogenesis Genes on Leptin Levels Regulation in Residents of the Coldest Region of Siberia Alena A. Nikanorova Nikolay A. Barashkov Vera G. Pshennikova Sergey S. Nakhodkin Nyurgun N. Gotovtsev Georgii P. Romanov Aisen V. Solovyev Sargylana S. Kuzmina Nikolay N. Sazonov Sardana A. Fedorova agris 2021-04-28 application/pdf https://doi.org/10.3390/ijms22094657 EN eng Multidisciplinary Digital Publishing Institute Molecular Endocrinology and Metabolism https://dx.doi.org/10.3390/ijms22094657 https://creativecommons.org/licenses/by/4.0/ International Journal of Molecular Sciences; Volume 22; Issue 9; Pages: 4657 leptin nonshivering thermogenesis UCP1 cold climate adaptation adipose tissue Yakut population Siberia Russia Text 2021 ftmdpi https://doi.org/10.3390/ijms22094657 2023-08-01T01:36:33Z Leptin plays an important role in thermoregulation and is possibly associated with the microevolutionary processes of human adaptation to a cold climate. In this study, based on the Yakut population (n = 281 individuals) living in the coldest region of Siberia (t°minimum −71.2 °C), we analyze the serum leptin levels and data of 14 single nucleotide polymorphisms (SNPs) of 10 genes (UCP1, UCP2, UCP3, FNDC5, PPARGC1A, CIDEA, PTGS2, TRPV1, LEPR, BDNF) that are possibly involved in nonshivering thermogenesis processes. Our results demonstrate that from 14 studied SNPs of 10 genes, 2 SNPs (the TT rs3811787 genotype of the UCP1 gene and the GG rs6265 genotype of the BDNF gene) were associated with the elevated leptin levels in Yakut females (p < 0.05). Furthermore, of these two SNPs, the rs3811787 of the UCP1 gene demonstrated more indications of natural selection for cold climate adaptation. The prevalence gradient of the T-allele (rs3811787) of UCP1 increased from the south to the north across Eurasia, along the shore of the Arctic Ocean. Thereby, our study suggests the potential involvement of the UCP1 gene in the leptin-mediated thermoregulation mechanism, while the distribution of its allelic variants is probably related to human adaptation to a cold climate. Text Arctic Arctic Ocean Yakut Siberia MDPI Open Access Publishing Arctic Arctic Ocean International Journal of Molecular Sciences 22 9 4657 |
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Open Polar |
collection |
MDPI Open Access Publishing |
op_collection_id |
ftmdpi |
language |
English |
topic |
leptin nonshivering thermogenesis UCP1 cold climate adaptation adipose tissue Yakut population Siberia Russia |
spellingShingle |
leptin nonshivering thermogenesis UCP1 cold climate adaptation adipose tissue Yakut population Siberia Russia Alena A. Nikanorova Nikolay A. Barashkov Vera G. Pshennikova Sergey S. Nakhodkin Nyurgun N. Gotovtsev Georgii P. Romanov Aisen V. Solovyev Sargylana S. Kuzmina Nikolay N. Sazonov Sardana A. Fedorova The Role of Nonshivering Thermogenesis Genes on Leptin Levels Regulation in Residents of the Coldest Region of Siberia |
topic_facet |
leptin nonshivering thermogenesis UCP1 cold climate adaptation adipose tissue Yakut population Siberia Russia |
description |
Leptin plays an important role in thermoregulation and is possibly associated with the microevolutionary processes of human adaptation to a cold climate. In this study, based on the Yakut population (n = 281 individuals) living in the coldest region of Siberia (t°minimum −71.2 °C), we analyze the serum leptin levels and data of 14 single nucleotide polymorphisms (SNPs) of 10 genes (UCP1, UCP2, UCP3, FNDC5, PPARGC1A, CIDEA, PTGS2, TRPV1, LEPR, BDNF) that are possibly involved in nonshivering thermogenesis processes. Our results demonstrate that from 14 studied SNPs of 10 genes, 2 SNPs (the TT rs3811787 genotype of the UCP1 gene and the GG rs6265 genotype of the BDNF gene) were associated with the elevated leptin levels in Yakut females (p < 0.05). Furthermore, of these two SNPs, the rs3811787 of the UCP1 gene demonstrated more indications of natural selection for cold climate adaptation. The prevalence gradient of the T-allele (rs3811787) of UCP1 increased from the south to the north across Eurasia, along the shore of the Arctic Ocean. Thereby, our study suggests the potential involvement of the UCP1 gene in the leptin-mediated thermoregulation mechanism, while the distribution of its allelic variants is probably related to human adaptation to a cold climate. |
format |
Text |
author |
Alena A. Nikanorova Nikolay A. Barashkov Vera G. Pshennikova Sergey S. Nakhodkin Nyurgun N. Gotovtsev Georgii P. Romanov Aisen V. Solovyev Sargylana S. Kuzmina Nikolay N. Sazonov Sardana A. Fedorova |
author_facet |
Alena A. Nikanorova Nikolay A. Barashkov Vera G. Pshennikova Sergey S. Nakhodkin Nyurgun N. Gotovtsev Georgii P. Romanov Aisen V. Solovyev Sargylana S. Kuzmina Nikolay N. Sazonov Sardana A. Fedorova |
author_sort |
Alena A. Nikanorova |
title |
The Role of Nonshivering Thermogenesis Genes on Leptin Levels Regulation in Residents of the Coldest Region of Siberia |
title_short |
The Role of Nonshivering Thermogenesis Genes on Leptin Levels Regulation in Residents of the Coldest Region of Siberia |
title_full |
The Role of Nonshivering Thermogenesis Genes on Leptin Levels Regulation in Residents of the Coldest Region of Siberia |
title_fullStr |
The Role of Nonshivering Thermogenesis Genes on Leptin Levels Regulation in Residents of the Coldest Region of Siberia |
title_full_unstemmed |
The Role of Nonshivering Thermogenesis Genes on Leptin Levels Regulation in Residents of the Coldest Region of Siberia |
title_sort |
role of nonshivering thermogenesis genes on leptin levels regulation in residents of the coldest region of siberia |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2021 |
url |
https://doi.org/10.3390/ijms22094657 |
op_coverage |
agris |
geographic |
Arctic Arctic Ocean |
geographic_facet |
Arctic Arctic Ocean |
genre |
Arctic Arctic Ocean Yakut Siberia |
genre_facet |
Arctic Arctic Ocean Yakut Siberia |
op_source |
International Journal of Molecular Sciences; Volume 22; Issue 9; Pages: 4657 |
op_relation |
Molecular Endocrinology and Metabolism https://dx.doi.org/10.3390/ijms22094657 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/ijms22094657 |
container_title |
International Journal of Molecular Sciences |
container_volume |
22 |
container_issue |
9 |
container_start_page |
4657 |
_version_ |
1774715107000975360 |