Insulin-Like Peptide Receptor-Mediated Signaling Pathways Orchestrate Regulation of Growth in the Pacific Oyster (Crassostrea gigas), as Revealed by Gene Expression Profiles
The involvement of insulin/insulin-like growth factor signaling (IIS) pathways in the growth regulation of marine invertebrates remains largely unexplored. In this study, we used a fast-growing Pacific oyster (Crassostrea gigas) variety “Haida No.1” as the material with which to unravel the role of...
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Online Access: | https://doi.org/10.3390/ijms22105259 |
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ftmdpi:oai:mdpi.com:/1422-0067/22/10/5259/ 2023-08-20T04:06:01+02:00 Insulin-Like Peptide Receptor-Mediated Signaling Pathways Orchestrate Regulation of Growth in the Pacific Oyster (Crassostrea gigas), as Revealed by Gene Expression Profiles Yongjing Li Huiru Fu Fuqiang Zhang Liting Ren Jing Tian Qi Li Shikai Liu agris 2021-05-17 application/pdf https://doi.org/10.3390/ijms22105259 EN eng Multidisciplinary Digital Publishing Institute Biochemistry https://dx.doi.org/10.3390/ijms22105259 https://creativecommons.org/licenses/by/4.0/ International Journal of Molecular Sciences; Volume 22; Issue 10; Pages: 5259 Crassostrea gigas IIS nutrient abundance temperature energy metabolism Text 2021 ftmdpi https://doi.org/10.3390/ijms22105259 2023-08-01T01:43:57Z The involvement of insulin/insulin-like growth factor signaling (IIS) pathways in the growth regulation of marine invertebrates remains largely unexplored. In this study, we used a fast-growing Pacific oyster (Crassostrea gigas) variety “Haida No.1” as the material with which to unravel the role of IIS systems in growth regulation in oysters. Systematic bioinformatics analyses allowed us to identify major components of the IIS signaling pathway and insulin-like peptide receptor (ILPR)-mediated signaling pathways, including PI3K-AKT, RAS-MAPK, and TOR, in C. gigas. The expression levels of the major genes in IIS and its downstream signaling pathways were significantly higher in “Haida No.1” than in wild oysters, suggesting their involvement in the growth regulation of C. gigas. The expression profiles of IIS and its downstream signaling pathway genes were significantly altered by nutrient abundance and culture temperature. These results suggest that the IIS signaling pathway coupled with the ILPR-mediated signaling pathways orchestrate the regulation of energy metabolism to control growth in Pacific oysters. Text Crassostrea gigas Pacific oyster MDPI Open Access Publishing Pacific International Journal of Molecular Sciences 22 10 5259 |
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MDPI Open Access Publishing |
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ftmdpi |
language |
English |
topic |
Crassostrea gigas IIS nutrient abundance temperature energy metabolism |
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Crassostrea gigas IIS nutrient abundance temperature energy metabolism Yongjing Li Huiru Fu Fuqiang Zhang Liting Ren Jing Tian Qi Li Shikai Liu Insulin-Like Peptide Receptor-Mediated Signaling Pathways Orchestrate Regulation of Growth in the Pacific Oyster (Crassostrea gigas), as Revealed by Gene Expression Profiles |
topic_facet |
Crassostrea gigas IIS nutrient abundance temperature energy metabolism |
description |
The involvement of insulin/insulin-like growth factor signaling (IIS) pathways in the growth regulation of marine invertebrates remains largely unexplored. In this study, we used a fast-growing Pacific oyster (Crassostrea gigas) variety “Haida No.1” as the material with which to unravel the role of IIS systems in growth regulation in oysters. Systematic bioinformatics analyses allowed us to identify major components of the IIS signaling pathway and insulin-like peptide receptor (ILPR)-mediated signaling pathways, including PI3K-AKT, RAS-MAPK, and TOR, in C. gigas. The expression levels of the major genes in IIS and its downstream signaling pathways were significantly higher in “Haida No.1” than in wild oysters, suggesting their involvement in the growth regulation of C. gigas. The expression profiles of IIS and its downstream signaling pathway genes were significantly altered by nutrient abundance and culture temperature. These results suggest that the IIS signaling pathway coupled with the ILPR-mediated signaling pathways orchestrate the regulation of energy metabolism to control growth in Pacific oysters. |
format |
Text |
author |
Yongjing Li Huiru Fu Fuqiang Zhang Liting Ren Jing Tian Qi Li Shikai Liu |
author_facet |
Yongjing Li Huiru Fu Fuqiang Zhang Liting Ren Jing Tian Qi Li Shikai Liu |
author_sort |
Yongjing Li |
title |
Insulin-Like Peptide Receptor-Mediated Signaling Pathways Orchestrate Regulation of Growth in the Pacific Oyster (Crassostrea gigas), as Revealed by Gene Expression Profiles |
title_short |
Insulin-Like Peptide Receptor-Mediated Signaling Pathways Orchestrate Regulation of Growth in the Pacific Oyster (Crassostrea gigas), as Revealed by Gene Expression Profiles |
title_full |
Insulin-Like Peptide Receptor-Mediated Signaling Pathways Orchestrate Regulation of Growth in the Pacific Oyster (Crassostrea gigas), as Revealed by Gene Expression Profiles |
title_fullStr |
Insulin-Like Peptide Receptor-Mediated Signaling Pathways Orchestrate Regulation of Growth in the Pacific Oyster (Crassostrea gigas), as Revealed by Gene Expression Profiles |
title_full_unstemmed |
Insulin-Like Peptide Receptor-Mediated Signaling Pathways Orchestrate Regulation of Growth in the Pacific Oyster (Crassostrea gigas), as Revealed by Gene Expression Profiles |
title_sort |
insulin-like peptide receptor-mediated signaling pathways orchestrate regulation of growth in the pacific oyster (crassostrea gigas), as revealed by gene expression profiles |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2021 |
url |
https://doi.org/10.3390/ijms22105259 |
op_coverage |
agris |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_source |
International Journal of Molecular Sciences; Volume 22; Issue 10; Pages: 5259 |
op_relation |
Biochemistry https://dx.doi.org/10.3390/ijms22105259 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/ijms22105259 |
container_title |
International Journal of Molecular Sciences |
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22 |
container_issue |
10 |
container_start_page |
5259 |
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1774716918341566464 |