Antarctic Krill Oil Diet Protects against Lipopolysaccharide-Induced Oxidative Stress, Neuroinflammation and Cognitive Impairment
Oxidative stress and neuroinflammation are implicated in the development and pathogenesis of Alzheimer’s disease (AD). Here, we investigated the anti-inflammatory and antioxidative effects of krill oil. Oil from Euphausia superba (Antarctic krill), an Antarctic marine species, is rich in eicosapenta...
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ftmdpi:oai:mdpi.com:/1422-0067/18/12/2554/ 2023-08-20T04:00:43+02:00 Antarctic Krill Oil Diet Protects against Lipopolysaccharide-Induced Oxidative Stress, Neuroinflammation and Cognitive Impairment Ji Choi Jun Jang Dong Son Hyung-Sik Im Ji Kim Joung Park Won Choi Sang-Bae Han Jin Hong agris 2017-11-28 application/pdf https://doi.org/10.3390/ijms18122554 EN eng Multidisciplinary Digital Publishing Institute Molecular Pathology, Diagnostics, and Therapeutics https://dx.doi.org/10.3390/ijms18122554 https://creativecommons.org/licenses/by/4.0/ International Journal of Molecular Sciences; Volume 18; Issue 12; Pages: 2554 neuroinflammation amyloidogenesis oxidation nuclear factor-κB krill oil Text 2017 ftmdpi https://doi.org/10.3390/ijms18122554 2023-07-31T21:17:54Z Oxidative stress and neuroinflammation are implicated in the development and pathogenesis of Alzheimer’s disease (AD). Here, we investigated the anti-inflammatory and antioxidative effects of krill oil. Oil from Euphausia superba (Antarctic krill), an Antarctic marine species, is rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). We examined whether krill oil diet (80 mg/kg/day for one month) prevents amyloidogenesis and cognitive impairment induced by intraperitoneal lipopolysaccharide (LPS) (250 µg/kg, seven times daily) injections in AD mice model and found that krill oil treatment inhibited the LPS-induced memory loss. We also found that krill oil treatment inhibited the LPS-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and decreased reactive oxygen species (ROS) and malondialdehyde levels. Krill oil also suppresses IκB degradation as well as p50 and p65 translocation into the nuclei of LPS-injected mice brain cells. In association with the inhibitory effect on neuroinflammation and oxidative stress, krill oil suppressed amyloid beta (1–42) peptide generation by the down-regulating APP and BACE1 expression in vivo. We found that eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (50 and 100 µM) dose-dependently decreased LPS-induced nitric oxide and ROS generation, and COX-2 and iNOS expression as well as nuclear factor-κB activity in cultured microglial BV-2 cells. These results suggest that krill oil ameliorated impairment via anti-inflammatory, antioxidative, and anti-amyloidogenic mechanisms. Text Antarc* Antarctic Antarctic Krill Euphausia superba MDPI Open Access Publishing Antarctic International Journal of Molecular Sciences 18 12 2554 |
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Open Polar |
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MDPI Open Access Publishing |
op_collection_id |
ftmdpi |
language |
English |
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neuroinflammation amyloidogenesis oxidation nuclear factor-κB krill oil |
spellingShingle |
neuroinflammation amyloidogenesis oxidation nuclear factor-κB krill oil Ji Choi Jun Jang Dong Son Hyung-Sik Im Ji Kim Joung Park Won Choi Sang-Bae Han Jin Hong Antarctic Krill Oil Diet Protects against Lipopolysaccharide-Induced Oxidative Stress, Neuroinflammation and Cognitive Impairment |
topic_facet |
neuroinflammation amyloidogenesis oxidation nuclear factor-κB krill oil |
description |
Oxidative stress and neuroinflammation are implicated in the development and pathogenesis of Alzheimer’s disease (AD). Here, we investigated the anti-inflammatory and antioxidative effects of krill oil. Oil from Euphausia superba (Antarctic krill), an Antarctic marine species, is rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). We examined whether krill oil diet (80 mg/kg/day for one month) prevents amyloidogenesis and cognitive impairment induced by intraperitoneal lipopolysaccharide (LPS) (250 µg/kg, seven times daily) injections in AD mice model and found that krill oil treatment inhibited the LPS-induced memory loss. We also found that krill oil treatment inhibited the LPS-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and decreased reactive oxygen species (ROS) and malondialdehyde levels. Krill oil also suppresses IκB degradation as well as p50 and p65 translocation into the nuclei of LPS-injected mice brain cells. In association with the inhibitory effect on neuroinflammation and oxidative stress, krill oil suppressed amyloid beta (1–42) peptide generation by the down-regulating APP and BACE1 expression in vivo. We found that eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (50 and 100 µM) dose-dependently decreased LPS-induced nitric oxide and ROS generation, and COX-2 and iNOS expression as well as nuclear factor-κB activity in cultured microglial BV-2 cells. These results suggest that krill oil ameliorated impairment via anti-inflammatory, antioxidative, and anti-amyloidogenic mechanisms. |
format |
Text |
author |
Ji Choi Jun Jang Dong Son Hyung-Sik Im Ji Kim Joung Park Won Choi Sang-Bae Han Jin Hong |
author_facet |
Ji Choi Jun Jang Dong Son Hyung-Sik Im Ji Kim Joung Park Won Choi Sang-Bae Han Jin Hong |
author_sort |
Ji Choi |
title |
Antarctic Krill Oil Diet Protects against Lipopolysaccharide-Induced Oxidative Stress, Neuroinflammation and Cognitive Impairment |
title_short |
Antarctic Krill Oil Diet Protects against Lipopolysaccharide-Induced Oxidative Stress, Neuroinflammation and Cognitive Impairment |
title_full |
Antarctic Krill Oil Diet Protects against Lipopolysaccharide-Induced Oxidative Stress, Neuroinflammation and Cognitive Impairment |
title_fullStr |
Antarctic Krill Oil Diet Protects against Lipopolysaccharide-Induced Oxidative Stress, Neuroinflammation and Cognitive Impairment |
title_full_unstemmed |
Antarctic Krill Oil Diet Protects against Lipopolysaccharide-Induced Oxidative Stress, Neuroinflammation and Cognitive Impairment |
title_sort |
antarctic krill oil diet protects against lipopolysaccharide-induced oxidative stress, neuroinflammation and cognitive impairment |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2017 |
url |
https://doi.org/10.3390/ijms18122554 |
op_coverage |
agris |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic Antarctic Krill Euphausia superba |
genre_facet |
Antarc* Antarctic Antarctic Krill Euphausia superba |
op_source |
International Journal of Molecular Sciences; Volume 18; Issue 12; Pages: 2554 |
op_relation |
Molecular Pathology, Diagnostics, and Therapeutics https://dx.doi.org/10.3390/ijms18122554 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/ijms18122554 |
container_title |
International Journal of Molecular Sciences |
container_volume |
18 |
container_issue |
12 |
container_start_page |
2554 |
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1774719925531705344 |