Verification of SNPs Associated with Growth Traits in Two Populations of Farmed Atlantic Salmon
Understanding the relationship between genetic variants and traits of economic importance in aquaculture species is pertinent to selective breeding programmes. High-throughput sequencing technologies have enabled the discovery of large numbers of SNPs in Atlantic salmon, and high density SNP arrays...
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ftmdpi:oai:mdpi.com:/1422-0067/17/1/5/ 2023-08-20T04:05:14+02:00 Verification of SNPs Associated with Growth Traits in Two Populations of Farmed Atlantic Salmon Hsin Tsai Alastair Hamilton Derrick Guy Alan Tinch Steve Bishop Ross Houston agris 2015-12-22 application/pdf https://doi.org/10.3390/ijms17010005 EN eng Multidisciplinary Digital Publishing Institute Biochemistry https://dx.doi.org/10.3390/ijms17010005 https://creativecommons.org/licenses/by/4.0/ International Journal of Molecular Sciences; Volume 17; Issue 1; Pages: 5 Atlantic salmon growth GWAS marker-assisted selection MAS SNP PCNT MEP1A Text 2015 ftmdpi https://doi.org/10.3390/ijms17010005 2023-07-31T20:49:02Z Understanding the relationship between genetic variants and traits of economic importance in aquaculture species is pertinent to selective breeding programmes. High-throughput sequencing technologies have enabled the discovery of large numbers of SNPs in Atlantic salmon, and high density SNP arrays now exist. A previous genome-wide association study (GWAS) using a high density SNP array (132K SNPs) has revealed the polygenic nature of early growth traits in salmon, but has also identified candidate SNPs showing suggestive associations with these traits. The aim of this study was to test the association of the candidate growth-associated SNPs in a separate population of farmed Atlantic salmon to verify their effects. Identifying SNP-trait associations in two populations provides evidence that the associations are true and robust. Using a large cohort (N = 1152), we successfully genotyped eight candidate SNPs from the previous GWAS, two of which were significantly associated with several growth and fillet traits measured at harvest. The genes proximal to these SNPs were identified by alignment to the salmon reference genome and are discussed in the context of their potential role in underpinning genetic variation in salmon growth. Text Atlantic salmon MDPI Open Access Publishing International Journal of Molecular Sciences 17 1 5 |
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Open Polar |
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MDPI Open Access Publishing |
op_collection_id |
ftmdpi |
language |
English |
topic |
Atlantic salmon growth GWAS marker-assisted selection MAS SNP PCNT MEP1A |
spellingShingle |
Atlantic salmon growth GWAS marker-assisted selection MAS SNP PCNT MEP1A Hsin Tsai Alastair Hamilton Derrick Guy Alan Tinch Steve Bishop Ross Houston Verification of SNPs Associated with Growth Traits in Two Populations of Farmed Atlantic Salmon |
topic_facet |
Atlantic salmon growth GWAS marker-assisted selection MAS SNP PCNT MEP1A |
description |
Understanding the relationship between genetic variants and traits of economic importance in aquaculture species is pertinent to selective breeding programmes. High-throughput sequencing technologies have enabled the discovery of large numbers of SNPs in Atlantic salmon, and high density SNP arrays now exist. A previous genome-wide association study (GWAS) using a high density SNP array (132K SNPs) has revealed the polygenic nature of early growth traits in salmon, but has also identified candidate SNPs showing suggestive associations with these traits. The aim of this study was to test the association of the candidate growth-associated SNPs in a separate population of farmed Atlantic salmon to verify their effects. Identifying SNP-trait associations in two populations provides evidence that the associations are true and robust. Using a large cohort (N = 1152), we successfully genotyped eight candidate SNPs from the previous GWAS, two of which were significantly associated with several growth and fillet traits measured at harvest. The genes proximal to these SNPs were identified by alignment to the salmon reference genome and are discussed in the context of their potential role in underpinning genetic variation in salmon growth. |
format |
Text |
author |
Hsin Tsai Alastair Hamilton Derrick Guy Alan Tinch Steve Bishop Ross Houston |
author_facet |
Hsin Tsai Alastair Hamilton Derrick Guy Alan Tinch Steve Bishop Ross Houston |
author_sort |
Hsin Tsai |
title |
Verification of SNPs Associated with Growth Traits in Two Populations of Farmed Atlantic Salmon |
title_short |
Verification of SNPs Associated with Growth Traits in Two Populations of Farmed Atlantic Salmon |
title_full |
Verification of SNPs Associated with Growth Traits in Two Populations of Farmed Atlantic Salmon |
title_fullStr |
Verification of SNPs Associated with Growth Traits in Two Populations of Farmed Atlantic Salmon |
title_full_unstemmed |
Verification of SNPs Associated with Growth Traits in Two Populations of Farmed Atlantic Salmon |
title_sort |
verification of snps associated with growth traits in two populations of farmed atlantic salmon |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2015 |
url |
https://doi.org/10.3390/ijms17010005 |
op_coverage |
agris |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
International Journal of Molecular Sciences; Volume 17; Issue 1; Pages: 5 |
op_relation |
Biochemistry https://dx.doi.org/10.3390/ijms17010005 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/ijms17010005 |
container_title |
International Journal of Molecular Sciences |
container_volume |
17 |
container_issue |
1 |
container_start_page |
5 |
_version_ |
1774715720482947072 |