Potential of Atlantic Codfish (Gadus morhua) Skin Collagen for Skincare Biomaterials
Collagen is the major structural protein in extracellular matrix present in connective tissues, including skin, being considered a promising material for skin regeneration. Marine organisms have been attracting interest amongst the industry as an alternative collagen source. In the present work, Atl...
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ftmdpi:oai:mdpi.com:/1420-3049/28/8/3394/ 2023-08-20T04:06:37+02:00 Potential of Atlantic Codfish (Gadus morhua) Skin Collagen for Skincare Biomaterials Cristina V. Rodrigues Rita O. Sousa Ana C. Carvalho Ana L. Alves Catarina F. Marques Mariana T. Cerqueira Rui L. Reis Tiago H. Silva agris 2023-04-12 application/pdf https://doi.org/10.3390/molecules28083394 EN eng Multidisciplinary Digital Publishing Institute Natural Products Chemistry https://dx.doi.org/10.3390/molecules28083394 https://creativecommons.org/licenses/by/4.0/ Molecules; Volume 28; Issue 8; Pages: 3394 Atlantic codfish collagen membranes skincare wound healing marine biomaterials Text 2023 ftmdpi https://doi.org/10.3390/molecules28083394 2023-08-01T09:39:41Z Collagen is the major structural protein in extracellular matrix present in connective tissues, including skin, being considered a promising material for skin regeneration. Marine organisms have been attracting interest amongst the industry as an alternative collagen source. In the present work, Atlantic codfish skin collagen was analyzed, to evaluate its potential for skincare. The collagen was extracted from two different skin batches (food industry by-product) using acetic acid (ASColl), confirming the method reproducibility since no significant yield differences were observed. The extracts characterization confirmed a profile compatible with type I collagen, without significant differences between batches or with bovine skin collagen (a reference material in biomedicine). Thermal analyses suggested ASColl’s native structure loss at 25 °C, and an inferior thermal stability to bovine skin collagen. No cytotoxicity was found for ASColl up to 10 mg/mL in keratinocytes (HaCaT cells). ASColl was used to develop membranes, which revealed smooth surfaces without significative morphological or biodegradability differences between batches. Their water absorption capacity and water contact angle indicated a hydrophilic feature. The metabolic activity and proliferation of HaCaT were improved by the membranes. Hence, ASColl membranes exhibited attractive characteristics to be applied in the biomedical and cosmeceutical field envisaging skincare. Text Gadus morhua MDPI Open Access Publishing Molecules 28 8 3394 |
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English |
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Atlantic codfish collagen membranes skincare wound healing marine biomaterials |
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Atlantic codfish collagen membranes skincare wound healing marine biomaterials Cristina V. Rodrigues Rita O. Sousa Ana C. Carvalho Ana L. Alves Catarina F. Marques Mariana T. Cerqueira Rui L. Reis Tiago H. Silva Potential of Atlantic Codfish (Gadus morhua) Skin Collagen for Skincare Biomaterials |
topic_facet |
Atlantic codfish collagen membranes skincare wound healing marine biomaterials |
description |
Collagen is the major structural protein in extracellular matrix present in connective tissues, including skin, being considered a promising material for skin regeneration. Marine organisms have been attracting interest amongst the industry as an alternative collagen source. In the present work, Atlantic codfish skin collagen was analyzed, to evaluate its potential for skincare. The collagen was extracted from two different skin batches (food industry by-product) using acetic acid (ASColl), confirming the method reproducibility since no significant yield differences were observed. The extracts characterization confirmed a profile compatible with type I collagen, without significant differences between batches or with bovine skin collagen (a reference material in biomedicine). Thermal analyses suggested ASColl’s native structure loss at 25 °C, and an inferior thermal stability to bovine skin collagen. No cytotoxicity was found for ASColl up to 10 mg/mL in keratinocytes (HaCaT cells). ASColl was used to develop membranes, which revealed smooth surfaces without significative morphological or biodegradability differences between batches. Their water absorption capacity and water contact angle indicated a hydrophilic feature. The metabolic activity and proliferation of HaCaT were improved by the membranes. Hence, ASColl membranes exhibited attractive characteristics to be applied in the biomedical and cosmeceutical field envisaging skincare. |
format |
Text |
author |
Cristina V. Rodrigues Rita O. Sousa Ana C. Carvalho Ana L. Alves Catarina F. Marques Mariana T. Cerqueira Rui L. Reis Tiago H. Silva |
author_facet |
Cristina V. Rodrigues Rita O. Sousa Ana C. Carvalho Ana L. Alves Catarina F. Marques Mariana T. Cerqueira Rui L. Reis Tiago H. Silva |
author_sort |
Cristina V. Rodrigues |
title |
Potential of Atlantic Codfish (Gadus morhua) Skin Collagen for Skincare Biomaterials |
title_short |
Potential of Atlantic Codfish (Gadus morhua) Skin Collagen for Skincare Biomaterials |
title_full |
Potential of Atlantic Codfish (Gadus morhua) Skin Collagen for Skincare Biomaterials |
title_fullStr |
Potential of Atlantic Codfish (Gadus morhua) Skin Collagen for Skincare Biomaterials |
title_full_unstemmed |
Potential of Atlantic Codfish (Gadus morhua) Skin Collagen for Skincare Biomaterials |
title_sort |
potential of atlantic codfish (gadus morhua) skin collagen for skincare biomaterials |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2023 |
url |
https://doi.org/10.3390/molecules28083394 |
op_coverage |
agris |
genre |
Gadus morhua |
genre_facet |
Gadus morhua |
op_source |
Molecules; Volume 28; Issue 8; Pages: 3394 |
op_relation |
Natural Products Chemistry https://dx.doi.org/10.3390/molecules28083394 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/molecules28083394 |
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Molecules |
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28 |
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8 |
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3394 |
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