In Silico Prospecting for Novel Bioactive Peptides from Seafoods: A Case Study on Pacific Oyster (Crassostrea gigas)
Pacific oyster (Crassostrea gigas), an abundant bivalve consumed across the Pacific, is known to possess a wide range of bioactivities. While there has been some work on its bioactive hydrolysates, the discovery of bioactive peptides (BAPs) remains limited due to the resource-intensive nature of the...
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2023
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ftmdpi:oai:mdpi.com:/1420-3049/28/2/651/ 2023-08-20T04:06:01+02:00 In Silico Prospecting for Novel Bioactive Peptides from Seafoods: A Case Study on Pacific Oyster (Crassostrea gigas) Leyi Zhou Rufa L. Mendez Jung Yeon Kwon agris 2023-01-09 application/pdf https://doi.org/10.3390/molecules28020651 EN eng Multidisciplinary Digital Publishing Institute https://dx.doi.org/10.3390/molecules28020651 https://creativecommons.org/licenses/by/4.0/ Molecules; Volume 28; Issue 2; Pages: 651 in silico prospecting bioactive peptides seafood Crassostrea gigas oyster proteins Text 2023 ftmdpi https://doi.org/10.3390/molecules28020651 2023-08-01T08:11:40Z Pacific oyster (Crassostrea gigas), an abundant bivalve consumed across the Pacific, is known to possess a wide range of bioactivities. While there has been some work on its bioactive hydrolysates, the discovery of bioactive peptides (BAPs) remains limited due to the resource-intensive nature of the existing discovery pipeline. To overcome this constraint, in silico-based prospecting is employed to accelerate BAP discovery. Major oyster proteins were digested virtually under a simulated gastrointestinal condition to generate virtual peptide products that were screened against existing databases for peptide bioactivities, toxicity, bitterness, stability in the intestine and in the blood, and novelty. Five peptide candidates were shortlisted showing antidiabetic, anti-inflammatory, antihypertensive, antimicrobial, and anticancer potential. By employing this approach, oyster BAPs were identified at a faster rate, with a wider applicability reach. With the growing market for peptide-based nutraceuticals, this provides an efficient workflow for candidate scouting and end-use investigation for targeted functional product preparation. Text Crassostrea gigas Pacific oyster MDPI Open Access Publishing Pacific Molecules 28 2 651 |
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language |
English |
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in silico prospecting bioactive peptides seafood Crassostrea gigas oyster proteins |
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in silico prospecting bioactive peptides seafood Crassostrea gigas oyster proteins Leyi Zhou Rufa L. Mendez Jung Yeon Kwon In Silico Prospecting for Novel Bioactive Peptides from Seafoods: A Case Study on Pacific Oyster (Crassostrea gigas) |
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in silico prospecting bioactive peptides seafood Crassostrea gigas oyster proteins |
description |
Pacific oyster (Crassostrea gigas), an abundant bivalve consumed across the Pacific, is known to possess a wide range of bioactivities. While there has been some work on its bioactive hydrolysates, the discovery of bioactive peptides (BAPs) remains limited due to the resource-intensive nature of the existing discovery pipeline. To overcome this constraint, in silico-based prospecting is employed to accelerate BAP discovery. Major oyster proteins were digested virtually under a simulated gastrointestinal condition to generate virtual peptide products that were screened against existing databases for peptide bioactivities, toxicity, bitterness, stability in the intestine and in the blood, and novelty. Five peptide candidates were shortlisted showing antidiabetic, anti-inflammatory, antihypertensive, antimicrobial, and anticancer potential. By employing this approach, oyster BAPs were identified at a faster rate, with a wider applicability reach. With the growing market for peptide-based nutraceuticals, this provides an efficient workflow for candidate scouting and end-use investigation for targeted functional product preparation. |
format |
Text |
author |
Leyi Zhou Rufa L. Mendez Jung Yeon Kwon |
author_facet |
Leyi Zhou Rufa L. Mendez Jung Yeon Kwon |
author_sort |
Leyi Zhou |
title |
In Silico Prospecting for Novel Bioactive Peptides from Seafoods: A Case Study on Pacific Oyster (Crassostrea gigas) |
title_short |
In Silico Prospecting for Novel Bioactive Peptides from Seafoods: A Case Study on Pacific Oyster (Crassostrea gigas) |
title_full |
In Silico Prospecting for Novel Bioactive Peptides from Seafoods: A Case Study on Pacific Oyster (Crassostrea gigas) |
title_fullStr |
In Silico Prospecting for Novel Bioactive Peptides from Seafoods: A Case Study on Pacific Oyster (Crassostrea gigas) |
title_full_unstemmed |
In Silico Prospecting for Novel Bioactive Peptides from Seafoods: A Case Study on Pacific Oyster (Crassostrea gigas) |
title_sort |
in silico prospecting for novel bioactive peptides from seafoods: a case study on pacific oyster (crassostrea gigas) |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2023 |
url |
https://doi.org/10.3390/molecules28020651 |
op_coverage |
agris |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_source |
Molecules; Volume 28; Issue 2; Pages: 651 |
op_relation |
https://dx.doi.org/10.3390/molecules28020651 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/molecules28020651 |
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Molecules |
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28 |
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