Bioactive Terphenyls Isolated from the Antarctic Lichen Stereocaulon alpinum
Three p-terphenyls (2–4)—2-hydroxy-3,5-dimethoxy-p-terphenyl (2), 2-hydroxy-3,6-dimethoxy-p-terphenyl (3), and 2,3,5,6-tetramethoxy-p-terphenyl (4)—were isolated for the first time as natural products along with seven known compounds (1, 5–10) from the Antarctic lichen Stereocaulon alpinum. Structur...
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ftmdpi:oai:mdpi.com:/1420-3049/27/7/2363/ 2023-08-20T04:00:34+02:00 Bioactive Terphenyls Isolated from the Antarctic Lichen Stereocaulon alpinum Kim-Hoa Phi Min-Ji Shin Seulah Lee Jae Eun So Ji Hee Kim Sung-Suk Suh Man Hyung Koo Seung Chul Shin Jin-Hyoung Kim Jun Hyuck Lee Ui Joung Youn agris 2022-04-06 application/pdf https://doi.org/10.3390/molecules27072363 EN eng Multidisciplinary Digital Publishing Institute https://dx.doi.org/10.3390/molecules27072363 https://creativecommons.org/licenses/by/4.0/ Molecules; Volume 27; Issue 7; Pages: 2363 Stereocaulon alpinum Antarctic lichen terphenyl cytotoxicity anti-inflammation Text 2022 ftmdpi https://doi.org/10.3390/molecules27072363 2023-08-01T04:40:58Z Three p-terphenyls (2–4)—2-hydroxy-3,5-dimethoxy-p-terphenyl (2), 2-hydroxy-3,6-dimethoxy-p-terphenyl (3), and 2,3,5,6-tetramethoxy-p-terphenyl (4)—were isolated for the first time as natural products along with seven known compounds (1, 5–10) from the Antarctic lichen Stereocaulon alpinum. Structures of the new compounds were elucidated by comprehensive analyses of 1D and 2D NMR and HREIMS experiments. Compound 3 exhibited cytotoxicity against HCT116 cells with the IC50 value of 3.76 ± 0.03 μM and also inhibited NO production in LPS-induced RAW264.7 macrophages with the IC50 value of 22.82 ± 0.015 μM. Text Antarc* Antarctic MDPI Open Access Publishing Antarctic The Antarctic Molecules 27 7 2363 |
institution |
Open Polar |
collection |
MDPI Open Access Publishing |
op_collection_id |
ftmdpi |
language |
English |
topic |
Stereocaulon alpinum Antarctic lichen terphenyl cytotoxicity anti-inflammation |
spellingShingle |
Stereocaulon alpinum Antarctic lichen terphenyl cytotoxicity anti-inflammation Kim-Hoa Phi Min-Ji Shin Seulah Lee Jae Eun So Ji Hee Kim Sung-Suk Suh Man Hyung Koo Seung Chul Shin Jin-Hyoung Kim Jun Hyuck Lee Ui Joung Youn Bioactive Terphenyls Isolated from the Antarctic Lichen Stereocaulon alpinum |
topic_facet |
Stereocaulon alpinum Antarctic lichen terphenyl cytotoxicity anti-inflammation |
description |
Three p-terphenyls (2–4)—2-hydroxy-3,5-dimethoxy-p-terphenyl (2), 2-hydroxy-3,6-dimethoxy-p-terphenyl (3), and 2,3,5,6-tetramethoxy-p-terphenyl (4)—were isolated for the first time as natural products along with seven known compounds (1, 5–10) from the Antarctic lichen Stereocaulon alpinum. Structures of the new compounds were elucidated by comprehensive analyses of 1D and 2D NMR and HREIMS experiments. Compound 3 exhibited cytotoxicity against HCT116 cells with the IC50 value of 3.76 ± 0.03 μM and also inhibited NO production in LPS-induced RAW264.7 macrophages with the IC50 value of 22.82 ± 0.015 μM. |
format |
Text |
author |
Kim-Hoa Phi Min-Ji Shin Seulah Lee Jae Eun So Ji Hee Kim Sung-Suk Suh Man Hyung Koo Seung Chul Shin Jin-Hyoung Kim Jun Hyuck Lee Ui Joung Youn |
author_facet |
Kim-Hoa Phi Min-Ji Shin Seulah Lee Jae Eun So Ji Hee Kim Sung-Suk Suh Man Hyung Koo Seung Chul Shin Jin-Hyoung Kim Jun Hyuck Lee Ui Joung Youn |
author_sort |
Kim-Hoa Phi |
title |
Bioactive Terphenyls Isolated from the Antarctic Lichen Stereocaulon alpinum |
title_short |
Bioactive Terphenyls Isolated from the Antarctic Lichen Stereocaulon alpinum |
title_full |
Bioactive Terphenyls Isolated from the Antarctic Lichen Stereocaulon alpinum |
title_fullStr |
Bioactive Terphenyls Isolated from the Antarctic Lichen Stereocaulon alpinum |
title_full_unstemmed |
Bioactive Terphenyls Isolated from the Antarctic Lichen Stereocaulon alpinum |
title_sort |
bioactive terphenyls isolated from the antarctic lichen stereocaulon alpinum |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2022 |
url |
https://doi.org/10.3390/molecules27072363 |
op_coverage |
agris |
geographic |
Antarctic The Antarctic |
geographic_facet |
Antarctic The Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
Molecules; Volume 27; Issue 7; Pages: 2363 |
op_relation |
https://dx.doi.org/10.3390/molecules27072363 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/molecules27072363 |
container_title |
Molecules |
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27 |
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7 |
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2363 |
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1774718959737634816 |