Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer’s Disease
The pathogenesis of Alzheimer’s disease (AD) is still unclear, and presently there is no cure for the disease that can be used for its treatment or to stop its progression. Here, we investigated the therapeutic potential of ramalin (isolated from the Antarctic lichen, Ramalina terebrata), which exhi...
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ftmdpi:oai:mdpi.com:/1420-3049/26/21/6445/ 2023-08-20T04:01:50+02:00 Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer’s Disease Tai Kyoung Kim Ju-Mi Hong Kyung Hee Kim Se Jong Han Il-Chan Kim Hyuncheol Oh Joung Han Yim agris 2021-10-26 application/pdf https://doi.org/10.3390/molecules26216445 EN eng Multidisciplinary Digital Publishing Institute https://dx.doi.org/10.3390/molecules26216445 https://creativecommons.org/licenses/by/4.0/ Molecules; Volume 26; Issue 21; Pages: 6445 Alzheimer’s disease ramalin derivatives therapeutic potential antioxidant β-secratase anti-inflammatory Text 2021 ftmdpi https://doi.org/10.3390/molecules26216445 2023-08-01T03:03:51Z The pathogenesis of Alzheimer’s disease (AD) is still unclear, and presently there is no cure for the disease that can be used for its treatment or to stop its progression. Here, we investigated the therapeutic potential of ramalin (isolated from the Antarctic lichen, Ramalina terebrata), which exhibits various physiological activities, in AD. Specifically, derivatives were synthesized based on the structure of ramalin, which has a strong antioxidant effect, BACE-1 inhibition activity, and anti-inflammatory effects. Therefore, ramalin and its derivatives exhibit activity against multiple targets associated with AD and can serve as potential therapeutic agents for the disease. Text Antarc* Antarctic MDPI Open Access Publishing Antarctic The Antarctic Molecules 26 21 6445 |
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Open Polar |
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MDPI Open Access Publishing |
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ftmdpi |
language |
English |
topic |
Alzheimer’s disease ramalin derivatives therapeutic potential antioxidant β-secratase anti-inflammatory |
spellingShingle |
Alzheimer’s disease ramalin derivatives therapeutic potential antioxidant β-secratase anti-inflammatory Tai Kyoung Kim Ju-Mi Hong Kyung Hee Kim Se Jong Han Il-Chan Kim Hyuncheol Oh Joung Han Yim Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer’s Disease |
topic_facet |
Alzheimer’s disease ramalin derivatives therapeutic potential antioxidant β-secratase anti-inflammatory |
description |
The pathogenesis of Alzheimer’s disease (AD) is still unclear, and presently there is no cure for the disease that can be used for its treatment or to stop its progression. Here, we investigated the therapeutic potential of ramalin (isolated from the Antarctic lichen, Ramalina terebrata), which exhibits various physiological activities, in AD. Specifically, derivatives were synthesized based on the structure of ramalin, which has a strong antioxidant effect, BACE-1 inhibition activity, and anti-inflammatory effects. Therefore, ramalin and its derivatives exhibit activity against multiple targets associated with AD and can serve as potential therapeutic agents for the disease. |
format |
Text |
author |
Tai Kyoung Kim Ju-Mi Hong Kyung Hee Kim Se Jong Han Il-Chan Kim Hyuncheol Oh Joung Han Yim |
author_facet |
Tai Kyoung Kim Ju-Mi Hong Kyung Hee Kim Se Jong Han Il-Chan Kim Hyuncheol Oh Joung Han Yim |
author_sort |
Tai Kyoung Kim |
title |
Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer’s Disease |
title_short |
Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer’s Disease |
title_full |
Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer’s Disease |
title_fullStr |
Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer’s Disease |
title_full_unstemmed |
Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer’s Disease |
title_sort |
potential of ramalin and its derivatives for the treatment of alzheimer’s disease |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2021 |
url |
https://doi.org/10.3390/molecules26216445 |
op_coverage |
agris |
geographic |
Antarctic The Antarctic |
geographic_facet |
Antarctic The Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
Molecules; Volume 26; Issue 21; Pages: 6445 |
op_relation |
https://dx.doi.org/10.3390/molecules26216445 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/molecules26216445 |
container_title |
Molecules |
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26 |
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21 |
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6445 |
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1774725043116310528 |