Gamma Aminobutyric Acid-Enriched Fermented Oyster (Crassostrea gigas) Increases the Length of the Growth Plate on the Proximal Tibia Bone in Sprague-Dawley Rats
Bone growth during childhood and puberty determines an adult’s final stature. Although several prior studies have reported that fermented oyster (FO) consisting of a high amount of gamma aminobutyric acid can be attributed to bone health, there is no research on the efficacy of FO on growth regulati...
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ftmdpi:oai:mdpi.com:/1420-3049/25/19/4375/ 2023-08-20T04:06:04+02:00 Gamma Aminobutyric Acid-Enriched Fermented Oyster (Crassostrea gigas) Increases the Length of the Growth Plate on the Proximal Tibia Bone in Sprague-Dawley Rats Hyesook Lee Hyun Hwangbo Seon Yeong Ji Min Yeong Kim So Young Kim Da Hye Kim Su Hyun Hong Su Jeong Lee Freshet Assefa Gi-Young Kim Eui Kyun Park Joung-Hyun Park Bae-Jin Lee You-Jin Jeon Yung Hyun Choi agris 2020-09-23 application/pdf https://doi.org/10.3390/molecules25194375 EN eng Multidisciplinary Digital Publishing Institute Natural Products Chemistry https://dx.doi.org/10.3390/molecules25194375 https://creativecommons.org/licenses/by/4.0/ Molecules; Volume 25; Issue 19; Pages: 4375 fermented oyster gamma aminobutyric acid insulin like growth factor-1 recombinant human growth hormone tibial growth plate Text 2020 ftmdpi https://doi.org/10.3390/molecules25194375 2023-08-01T00:09:52Z Bone growth during childhood and puberty determines an adult’s final stature. Although several prior studies have reported that fermented oyster (FO) consisting of a high amount of gamma aminobutyric acid can be attributed to bone health, there is no research on the efficacy of FO on growth regulation and the proximal tibial growth plate. Therefore, in this study, we investigated the effect of FO oral administration on hepatic and serum growth regulator levels and the development of the proximal tibial growth plate in young Sprague-Dawley rats. Both oral administration of FO (FO 100, 100 mg/kg FO and FO 200, 200 mg/kg FO) and subcutaneous injection of recombinant human growth hormone (rhGH, 200 μg/kg of rhGH) for two weeks showed no toxicity. Circulating levels of growth hormone (GH) significantly increased in the FO 200 group. The expression and secretion of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) were enhanced by FO administration. FO administration promoted the expression of bone morphogenic proteins IGF-1 and IGFBP-3 in the proximal tibial growth plate. This positive effect of FO resulted in incremental growth of the entire plate length by expanding the proliferating and hypertrophic zones in the proximal tibial growth plate. Collectively, our results suggested that oral administration of FO is beneficial for bone health, which may ultimately result in increased height. Text Crassostrea gigas MDPI Open Access Publishing Molecules 25 19 4375 |
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MDPI Open Access Publishing |
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ftmdpi |
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English |
topic |
fermented oyster gamma aminobutyric acid insulin like growth factor-1 recombinant human growth hormone tibial growth plate |
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fermented oyster gamma aminobutyric acid insulin like growth factor-1 recombinant human growth hormone tibial growth plate Hyesook Lee Hyun Hwangbo Seon Yeong Ji Min Yeong Kim So Young Kim Da Hye Kim Su Hyun Hong Su Jeong Lee Freshet Assefa Gi-Young Kim Eui Kyun Park Joung-Hyun Park Bae-Jin Lee You-Jin Jeon Yung Hyun Choi Gamma Aminobutyric Acid-Enriched Fermented Oyster (Crassostrea gigas) Increases the Length of the Growth Plate on the Proximal Tibia Bone in Sprague-Dawley Rats |
topic_facet |
fermented oyster gamma aminobutyric acid insulin like growth factor-1 recombinant human growth hormone tibial growth plate |
description |
Bone growth during childhood and puberty determines an adult’s final stature. Although several prior studies have reported that fermented oyster (FO) consisting of a high amount of gamma aminobutyric acid can be attributed to bone health, there is no research on the efficacy of FO on growth regulation and the proximal tibial growth plate. Therefore, in this study, we investigated the effect of FO oral administration on hepatic and serum growth regulator levels and the development of the proximal tibial growth plate in young Sprague-Dawley rats. Both oral administration of FO (FO 100, 100 mg/kg FO and FO 200, 200 mg/kg FO) and subcutaneous injection of recombinant human growth hormone (rhGH, 200 μg/kg of rhGH) for two weeks showed no toxicity. Circulating levels of growth hormone (GH) significantly increased in the FO 200 group. The expression and secretion of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) were enhanced by FO administration. FO administration promoted the expression of bone morphogenic proteins IGF-1 and IGFBP-3 in the proximal tibial growth plate. This positive effect of FO resulted in incremental growth of the entire plate length by expanding the proliferating and hypertrophic zones in the proximal tibial growth plate. Collectively, our results suggested that oral administration of FO is beneficial for bone health, which may ultimately result in increased height. |
format |
Text |
author |
Hyesook Lee Hyun Hwangbo Seon Yeong Ji Min Yeong Kim So Young Kim Da Hye Kim Su Hyun Hong Su Jeong Lee Freshet Assefa Gi-Young Kim Eui Kyun Park Joung-Hyun Park Bae-Jin Lee You-Jin Jeon Yung Hyun Choi |
author_facet |
Hyesook Lee Hyun Hwangbo Seon Yeong Ji Min Yeong Kim So Young Kim Da Hye Kim Su Hyun Hong Su Jeong Lee Freshet Assefa Gi-Young Kim Eui Kyun Park Joung-Hyun Park Bae-Jin Lee You-Jin Jeon Yung Hyun Choi |
author_sort |
Hyesook Lee |
title |
Gamma Aminobutyric Acid-Enriched Fermented Oyster (Crassostrea gigas) Increases the Length of the Growth Plate on the Proximal Tibia Bone in Sprague-Dawley Rats |
title_short |
Gamma Aminobutyric Acid-Enriched Fermented Oyster (Crassostrea gigas) Increases the Length of the Growth Plate on the Proximal Tibia Bone in Sprague-Dawley Rats |
title_full |
Gamma Aminobutyric Acid-Enriched Fermented Oyster (Crassostrea gigas) Increases the Length of the Growth Plate on the Proximal Tibia Bone in Sprague-Dawley Rats |
title_fullStr |
Gamma Aminobutyric Acid-Enriched Fermented Oyster (Crassostrea gigas) Increases the Length of the Growth Plate on the Proximal Tibia Bone in Sprague-Dawley Rats |
title_full_unstemmed |
Gamma Aminobutyric Acid-Enriched Fermented Oyster (Crassostrea gigas) Increases the Length of the Growth Plate on the Proximal Tibia Bone in Sprague-Dawley Rats |
title_sort |
gamma aminobutyric acid-enriched fermented oyster (crassostrea gigas) increases the length of the growth plate on the proximal tibia bone in sprague-dawley rats |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2020 |
url |
https://doi.org/10.3390/molecules25194375 |
op_coverage |
agris |
genre |
Crassostrea gigas |
genre_facet |
Crassostrea gigas |
op_source |
Molecules; Volume 25; Issue 19; Pages: 4375 |
op_relation |
Natural Products Chemistry https://dx.doi.org/10.3390/molecules25194375 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/molecules25194375 |
container_title |
Molecules |
container_volume |
25 |
container_issue |
19 |
container_start_page |
4375 |
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1774716991400050688 |