Schwere Azidose: Differenzialdiagnostik und Therapie [Severe acidosis: differential diagnostics and treatment]
The extracellular H(+) ion concentration in the human body is adjusted within close limits to 40 ± 0.3 nmol/l in blood to ensure maintenance of normal cellular and extracellular homeostasis. The carbonic acid-bicarbonate buffer system is the major regulator of acid-base homeostasis and is readily ac...
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ftmdcberlin:oai:edoc.mdc-berlin.de:18722 2023-05-15T15:52:36+02:00 Schwere Azidose: Differenzialdiagnostik und Therapie [Severe acidosis: differential diagnostics and treatment] Lehner, L.J. Oppert, M. Kettritz, R. 2019-11 http://edoc.mdc-berlin.de/18722/ https://edoc.mdc-berlin.de/18722/ https://doi.org/10.1007/s11560-019-00374-w unknown Springer Schwere Azidose: Differenzialdiagnostik und Therapie [Severe acidosis: differential diagnostics and treatment]. Lehner, L.J. and Oppert, M. and Kettritz, R. Nephrologe 14 (6): 431-437. November 2019 Cardiovascular and Metabolic Diseases Review PeerReviewed 2019 ftmdcberlin https://doi.org/10.1007/s11560-019-00374-w 2022-01-01T19:12:59Z The extracellular H(+) ion concentration in the human body is adjusted within close limits to 40 ± 0.3 nmol/l in blood to ensure maintenance of normal cellular and extracellular homeostasis. The carbonic acid-bicarbonate buffer system is the major regulator of acid-base homeostasis and is readily accessible for the clinician through determination of pH, pCO(2) and HCO3(–). Acidosis is primarily a respiratory or metabolic disorder causing acidemia (H(+) >43 nmol/l or pH <7.37). Severe acidosis (H(+) >60 nmol/l or pH <7.2) needs to be diagnosed rapidly and treated according to the underlying condition. A systematic approach with simple bedside diagnostic tools helps to characterize the underlying acid-base disorder, to identify the etiology and to initiate the appropriate causal treatment. Review Carbonic acid Max-Delbrueck-Center for Molecular Medicine, Berlin: MDC Repository Der Nephrologe 14 6 431 437 |
institution |
Open Polar |
collection |
Max-Delbrueck-Center for Molecular Medicine, Berlin: MDC Repository |
op_collection_id |
ftmdcberlin |
language |
unknown |
topic |
Cardiovascular and Metabolic Diseases |
spellingShingle |
Cardiovascular and Metabolic Diseases Lehner, L.J. Oppert, M. Kettritz, R. Schwere Azidose: Differenzialdiagnostik und Therapie [Severe acidosis: differential diagnostics and treatment] |
topic_facet |
Cardiovascular and Metabolic Diseases |
description |
The extracellular H(+) ion concentration in the human body is adjusted within close limits to 40 ± 0.3 nmol/l in blood to ensure maintenance of normal cellular and extracellular homeostasis. The carbonic acid-bicarbonate buffer system is the major regulator of acid-base homeostasis and is readily accessible for the clinician through determination of pH, pCO(2) and HCO3(–). Acidosis is primarily a respiratory or metabolic disorder causing acidemia (H(+) >43 nmol/l or pH <7.37). Severe acidosis (H(+) >60 nmol/l or pH <7.2) needs to be diagnosed rapidly and treated according to the underlying condition. A systematic approach with simple bedside diagnostic tools helps to characterize the underlying acid-base disorder, to identify the etiology and to initiate the appropriate causal treatment. |
format |
Review |
author |
Lehner, L.J. Oppert, M. Kettritz, R. |
author_facet |
Lehner, L.J. Oppert, M. Kettritz, R. |
author_sort |
Lehner, L.J. |
title |
Schwere Azidose: Differenzialdiagnostik und Therapie [Severe acidosis: differential diagnostics and treatment] |
title_short |
Schwere Azidose: Differenzialdiagnostik und Therapie [Severe acidosis: differential diagnostics and treatment] |
title_full |
Schwere Azidose: Differenzialdiagnostik und Therapie [Severe acidosis: differential diagnostics and treatment] |
title_fullStr |
Schwere Azidose: Differenzialdiagnostik und Therapie [Severe acidosis: differential diagnostics and treatment] |
title_full_unstemmed |
Schwere Azidose: Differenzialdiagnostik und Therapie [Severe acidosis: differential diagnostics and treatment] |
title_sort |
schwere azidose: differenzialdiagnostik und therapie [severe acidosis: differential diagnostics and treatment] |
publisher |
Springer |
publishDate |
2019 |
url |
http://edoc.mdc-berlin.de/18722/ https://edoc.mdc-berlin.de/18722/ https://doi.org/10.1007/s11560-019-00374-w |
genre |
Carbonic acid |
genre_facet |
Carbonic acid |
op_relation |
Schwere Azidose: Differenzialdiagnostik und Therapie [Severe acidosis: differential diagnostics and treatment]. Lehner, L.J. and Oppert, M. and Kettritz, R. Nephrologe 14 (6): 431-437. November 2019 |
op_doi |
https://doi.org/10.1007/s11560-019-00374-w |
container_title |
Der Nephrologe |
container_volume |
14 |
container_issue |
6 |
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431 |
op_container_end_page |
437 |
_version_ |
1766387734120759296 |