Natural selection acts on Atlantic salmon major histocompatibility (MH) variability in the wild
Peer-reviewed. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Proc. R. Soc. B. To access the final edited and published work see doi:10.1098/rspb.2006.0053 Pathogen-driven balancing selection is thought to maintain polymorphism in major histocompa...
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Online Access: | http://hdl.handle.net/10793/954 https://doi.org/10.1098/rspb.2006.0053 |
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ftmarineinst:oai:oar.marine.ie:10793/954 2023-05-15T15:30:17+02:00 Natural selection acts on Atlantic salmon major histocompatibility (MH) variability in the wild de Eyto, E. McGinnity, P. Consuegra, S. Coughlan, J. Tufto, J. Farrell, K. Megens, H.J. Jordan, W. Cross, T. Stet, R.J.M. 2007 http://hdl.handle.net/10793/954 https://doi.org/10.1098/rspb.2006.0053 en eng Royal Society Publishing Proceedings of the Royal Society B: Biological Sciences;274(1611), 861-869 De Eyto, E., McGinnity, P., Consuegra, S., Coughlan, J., Tufto, J., Farrell, K., . & Stet, R. J. (2007). Natural selection acts on Atlantic salmon major histocompatibility (MH) variability in the wild. Proceedings of the Royal Society B: Biological Sciences, 274(1611), 861-869. doi:10.1098/rspb.2006.0053 http://hdl.handle.net/10793/954 MHC (major histocompatibility complex) natural selection Atlantic salmon Article 2007 ftmarineinst https://doi.org/10.1098/rspb.2006.0053 2022-07-27T09:39:10Z Peer-reviewed. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Proc. R. Soc. B. To access the final edited and published work see doi:10.1098/rspb.2006.0053 Pathogen-driven balancing selection is thought to maintain polymorphism in major histocompatibility (MH) genes. However, there have been few empirical demonstrations of selection acting on MH loci in natural populations. To determine whether natural selection on MH genes has fitness consequences for wild Atlantic salmon in natural conditions, we compared observed genotype frequencies of Atlantic salmon (Salmo salar) surviving in a river six months after their introduction as eggs with frequencies expected from parental crosses. We found significant differences between expected and observed genotype frequencies at the MH class II alpha locus, but not at a MH class I-linked microsatellite or at seven non-MH-linked microsatellite loci. We therefore conclude that selection at the MH class II alpha locus was a result of disease-mediated natural selection, rather than any demographic event. We also show that survival was associated with additive allelic effects at the MH class II alpha locus. Our results have implications for both the conservation of wild salmon stocks and the management of disease in hatchery fish. We conclude that natural or hatchery populations have the best chance of dealing with episodic and variable disease challenges if MH genetic variation is preserved both within and among populations. Article in Journal/Newspaper Atlantic salmon Salmo salar Marine Institute Open Access Repository Proceedings of the Royal Society B: Biological Sciences 274 1611 861 869 |
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Open Polar |
collection |
Marine Institute Open Access Repository |
op_collection_id |
ftmarineinst |
language |
English |
topic |
MHC (major histocompatibility complex) natural selection Atlantic salmon |
spellingShingle |
MHC (major histocompatibility complex) natural selection Atlantic salmon de Eyto, E. McGinnity, P. Consuegra, S. Coughlan, J. Tufto, J. Farrell, K. Megens, H.J. Jordan, W. Cross, T. Stet, R.J.M. Natural selection acts on Atlantic salmon major histocompatibility (MH) variability in the wild |
topic_facet |
MHC (major histocompatibility complex) natural selection Atlantic salmon |
description |
Peer-reviewed. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Proc. R. Soc. B. To access the final edited and published work see doi:10.1098/rspb.2006.0053 Pathogen-driven balancing selection is thought to maintain polymorphism in major histocompatibility (MH) genes. However, there have been few empirical demonstrations of selection acting on MH loci in natural populations. To determine whether natural selection on MH genes has fitness consequences for wild Atlantic salmon in natural conditions, we compared observed genotype frequencies of Atlantic salmon (Salmo salar) surviving in a river six months after their introduction as eggs with frequencies expected from parental crosses. We found significant differences between expected and observed genotype frequencies at the MH class II alpha locus, but not at a MH class I-linked microsatellite or at seven non-MH-linked microsatellite loci. We therefore conclude that selection at the MH class II alpha locus was a result of disease-mediated natural selection, rather than any demographic event. We also show that survival was associated with additive allelic effects at the MH class II alpha locus. Our results have implications for both the conservation of wild salmon stocks and the management of disease in hatchery fish. We conclude that natural or hatchery populations have the best chance of dealing with episodic and variable disease challenges if MH genetic variation is preserved both within and among populations. |
format |
Article in Journal/Newspaper |
author |
de Eyto, E. McGinnity, P. Consuegra, S. Coughlan, J. Tufto, J. Farrell, K. Megens, H.J. Jordan, W. Cross, T. Stet, R.J.M. |
author_facet |
de Eyto, E. McGinnity, P. Consuegra, S. Coughlan, J. Tufto, J. Farrell, K. Megens, H.J. Jordan, W. Cross, T. Stet, R.J.M. |
author_sort |
de Eyto, E. |
title |
Natural selection acts on Atlantic salmon major histocompatibility (MH) variability in the wild |
title_short |
Natural selection acts on Atlantic salmon major histocompatibility (MH) variability in the wild |
title_full |
Natural selection acts on Atlantic salmon major histocompatibility (MH) variability in the wild |
title_fullStr |
Natural selection acts on Atlantic salmon major histocompatibility (MH) variability in the wild |
title_full_unstemmed |
Natural selection acts on Atlantic salmon major histocompatibility (MH) variability in the wild |
title_sort |
natural selection acts on atlantic salmon major histocompatibility (mh) variability in the wild |
publisher |
Royal Society Publishing |
publishDate |
2007 |
url |
http://hdl.handle.net/10793/954 https://doi.org/10.1098/rspb.2006.0053 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
Proceedings of the Royal Society B: Biological Sciences;274(1611), 861-869 De Eyto, E., McGinnity, P., Consuegra, S., Coughlan, J., Tufto, J., Farrell, K., . & Stet, R. J. (2007). Natural selection acts on Atlantic salmon major histocompatibility (MH) variability in the wild. Proceedings of the Royal Society B: Biological Sciences, 274(1611), 861-869. doi:10.1098/rspb.2006.0053 http://hdl.handle.net/10793/954 |
op_doi |
https://doi.org/10.1098/rspb.2006.0053 |
container_title |
Proceedings of the Royal Society B: Biological Sciences |
container_volume |
274 |
container_issue |
1611 |
container_start_page |
861 |
op_container_end_page |
869 |
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1766360731717992448 |