Primed for success:oyster parents treated with poly(I:C) produce offspring with enhanced protection against Ostreid herpesvirus type I infection
The Pacific oyster (Crassostrea gigas) is farmed globally. Ostreid herpesvirus (OsHV-1) causes severe mortalities of farmed C. gigas. Management of OsHV-1 has proven difficult. Oysters treated with poly(I:C) exhibit enhanced protection (EP) against OsHV-1. This chemical treatment is highly effective...
Published in: | Molecular Immunology |
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ftmacquarieunicr:oai:https://researchers.mq.edu.au:publications/a96eceef-e7ee-4bac-bada-eac315901f7c 2024-09-30T14:33:58+00:00 Primed for success:oyster parents treated with poly(I:C) produce offspring with enhanced protection against Ostreid herpesvirus type I infection Green, Timothy J. Helbig, Karla Speck, Peter Raftos, David A. 2016-10-01 https://researchers.mq.edu.au/en/publications/a96eceef-e7ee-4bac-bada-eac315901f7c https://doi.org/10.1016/j.molimm.2016.09.002 http://www.scopus.com/inward/record.url?scp=84989206819&partnerID=8YFLogxK eng eng info:eu-repo/semantics/closedAccess Green , T J , Helbig , K , Speck , P & Raftos , D A 2016 , ' Primed for success : oyster parents treated with poly(I:C) produce offspring with enhanced protection against Ostreid herpesvirus type I infection ' , Molecular Immunology , vol. 78 , pp. 113-120 . https://doi.org/10.1016/j.molimm.2016.09.002 Crassostrea OsHV-1 trans-generational immune priming trained immunity invertebrate antiviral response article 2016 ftmacquarieunicr https://doi.org/10.1016/j.molimm.2016.09.002 2024-09-11T23:44:59Z The Pacific oyster (Crassostrea gigas) is farmed globally. Ostreid herpesvirus (OsHV-1) causes severe mortalities of farmed C. gigas. Management of OsHV-1 has proven difficult. Oysters treated with poly(I:C) exhibit enhanced protection (EP) against OsHV-1. This chemical treatment is highly effective, but it is not feasible to treat every oyster on a farm. To circumvent this practical limitation, previous studies on arthropods have suggested that EP can be transferred from parents to their offspring (trans-generational EP, TGEP). This suggests that the treatment of relatively few parents could be used to produce large numbers of offspring with TGEP. Here, we investigated TGEP in oysters to test whether it might be used as a cost effective management tool to control OsHV-1. We found that offspring (D-veliger larvae) produced from poly(I:C)-treated parents had double the chance of surviving exposure to OsHV-1 compared to controls. Furthermore, the larvae of poly(I:C)-treated parents contained elevated levels of mRNA encoding a key transcription factor that regulates antiviral immunity (IRF2). Poly(I:C) treatment had no effect on the survival of oyster parents. Hence, the enhanced immunity of their offspring could not be explained by genetic selection, and instead may reflect epigenetic reprogramming or maternal provisioning. Article in Journal/Newspaper Crassostrea gigas Pacific oyster Macquarie University Research Portal Pacific Molecular Immunology 78 113 120 |
institution |
Open Polar |
collection |
Macquarie University Research Portal |
op_collection_id |
ftmacquarieunicr |
language |
English |
topic |
Crassostrea OsHV-1 trans-generational immune priming trained immunity invertebrate antiviral response |
spellingShingle |
Crassostrea OsHV-1 trans-generational immune priming trained immunity invertebrate antiviral response Green, Timothy J. Helbig, Karla Speck, Peter Raftos, David A. Primed for success:oyster parents treated with poly(I:C) produce offspring with enhanced protection against Ostreid herpesvirus type I infection |
topic_facet |
Crassostrea OsHV-1 trans-generational immune priming trained immunity invertebrate antiviral response |
description |
The Pacific oyster (Crassostrea gigas) is farmed globally. Ostreid herpesvirus (OsHV-1) causes severe mortalities of farmed C. gigas. Management of OsHV-1 has proven difficult. Oysters treated with poly(I:C) exhibit enhanced protection (EP) against OsHV-1. This chemical treatment is highly effective, but it is not feasible to treat every oyster on a farm. To circumvent this practical limitation, previous studies on arthropods have suggested that EP can be transferred from parents to their offspring (trans-generational EP, TGEP). This suggests that the treatment of relatively few parents could be used to produce large numbers of offspring with TGEP. Here, we investigated TGEP in oysters to test whether it might be used as a cost effective management tool to control OsHV-1. We found that offspring (D-veliger larvae) produced from poly(I:C)-treated parents had double the chance of surviving exposure to OsHV-1 compared to controls. Furthermore, the larvae of poly(I:C)-treated parents contained elevated levels of mRNA encoding a key transcription factor that regulates antiviral immunity (IRF2). Poly(I:C) treatment had no effect on the survival of oyster parents. Hence, the enhanced immunity of their offspring could not be explained by genetic selection, and instead may reflect epigenetic reprogramming or maternal provisioning. |
format |
Article in Journal/Newspaper |
author |
Green, Timothy J. Helbig, Karla Speck, Peter Raftos, David A. |
author_facet |
Green, Timothy J. Helbig, Karla Speck, Peter Raftos, David A. |
author_sort |
Green, Timothy J. |
title |
Primed for success:oyster parents treated with poly(I:C) produce offspring with enhanced protection against Ostreid herpesvirus type I infection |
title_short |
Primed for success:oyster parents treated with poly(I:C) produce offspring with enhanced protection against Ostreid herpesvirus type I infection |
title_full |
Primed for success:oyster parents treated with poly(I:C) produce offspring with enhanced protection against Ostreid herpesvirus type I infection |
title_fullStr |
Primed for success:oyster parents treated with poly(I:C) produce offspring with enhanced protection against Ostreid herpesvirus type I infection |
title_full_unstemmed |
Primed for success:oyster parents treated with poly(I:C) produce offspring with enhanced protection against Ostreid herpesvirus type I infection |
title_sort |
primed for success:oyster parents treated with poly(i:c) produce offspring with enhanced protection against ostreid herpesvirus type i infection |
publishDate |
2016 |
url |
https://researchers.mq.edu.au/en/publications/a96eceef-e7ee-4bac-bada-eac315901f7c https://doi.org/10.1016/j.molimm.2016.09.002 http://www.scopus.com/inward/record.url?scp=84989206819&partnerID=8YFLogxK |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_source |
Green , T J , Helbig , K , Speck , P & Raftos , D A 2016 , ' Primed for success : oyster parents treated with poly(I:C) produce offspring with enhanced protection against Ostreid herpesvirus type I infection ' , Molecular Immunology , vol. 78 , pp. 113-120 . https://doi.org/10.1016/j.molimm.2016.09.002 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1016/j.molimm.2016.09.002 |
container_title |
Molecular Immunology |
container_volume |
78 |
container_start_page |
113 |
op_container_end_page |
120 |
_version_ |
1811637719260987392 |