Transgenerational plasticity and antiviral immunity in the Pacific oyster ( Crassostrea gigas ) against Ostreid herpesvirus 1 (OsHV-1)
The oyster's immune system is capable of adapting upon exposure to a pathogen-associated molecular pattern (PAMP) to have an enhanced secondary response against the same type of pathogen. This has been demonstrated using poly(I:C) to elicit an antiviral response in the Pacific oyster ( Crassost...
Published in: | Developmental & Comparative Immunology |
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Language: | English |
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2019
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Online Access: | https://researchers.mq.edu.au/en/publications/60d0a282-5e72-45a6-9937-df724072299c https://doi.org/10.1016/j.dci.2018.09.022 http://www.scopus.com/inward/record.url?scp=85056176022&partnerID=8YFLogxK |
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ftmacquarieunicr:oai:https://researchers.mq.edu.au:publications/60d0a282-5e72-45a6-9937-df724072299c 2024-06-02T08:05:34+00:00 Transgenerational plasticity and antiviral immunity in the Pacific oyster ( Crassostrea gigas ) against Ostreid herpesvirus 1 (OsHV-1) Lafont, Maxime Goncalves, Priscila Guo, Ximing Montagnani, Caroline Raftos, David Green, Timothy 2019-02 https://researchers.mq.edu.au/en/publications/60d0a282-5e72-45a6-9937-df724072299c https://doi.org/10.1016/j.dci.2018.09.022 http://www.scopus.com/inward/record.url?scp=85056176022&partnerID=8YFLogxK eng eng info:eu-repo/semantics/closedAccess Lafont , M , Goncalves , P , Guo , X , Montagnani , C , Raftos , D & Green , T 2019 , ' Transgenerational plasticity and antiviral immunity in the Pacific oyster ( Crassostrea gigas ) against Ostreid herpesvirus 1 (OsHV-1) ' , Developmental and Comparative Immunology , vol. 91 , pp. 17-25 . https://doi.org/10.1016/j.dci.2018.09.022 Crassostrea gigas OsHV-1 transgenerational immune priming trained immunity RNA-seq article 2019 ftmacquarieunicr https://doi.org/10.1016/j.dci.2018.09.022 2024-05-22T23:48:03Z The oyster's immune system is capable of adapting upon exposure to a pathogen-associated molecular pattern (PAMP) to have an enhanced secondary response against the same type of pathogen. This has been demonstrated using poly(I:C) to elicit an antiviral response in the Pacific oyster ( Crassostrea gigas ) against Ostreid herpesvirus (OsHV-1). Improved survival following exposure to poly(I:C) has been found in later life stages (within-generational immune priming) and in the next generation (transgenerational immune priming). The mechanism that the oyster uses to transfer immunity to the next generation is unknown. Here we show that oyster larvae have higher survival to OsHV-1 when their mothers, but not their fathers, are exposed to poly(I:C) prior to spawning. RNA-seq provided no evidence to suggest that parental exposure to poly(I:C) reconfigures antiviral gene expression in unchallenged larvae. We conclude that the improved survival of larvae might occur via maternal provisioning of antiviral compounds in the eggs. Article in Journal/Newspaper Crassostrea gigas Pacific oyster Macquarie University Research Portal Pacific Developmental & Comparative Immunology 91 17 25 |
institution |
Open Polar |
collection |
Macquarie University Research Portal |
op_collection_id |
ftmacquarieunicr |
language |
English |
topic |
Crassostrea gigas OsHV-1 transgenerational immune priming trained immunity RNA-seq |
spellingShingle |
Crassostrea gigas OsHV-1 transgenerational immune priming trained immunity RNA-seq Lafont, Maxime Goncalves, Priscila Guo, Ximing Montagnani, Caroline Raftos, David Green, Timothy Transgenerational plasticity and antiviral immunity in the Pacific oyster ( Crassostrea gigas ) against Ostreid herpesvirus 1 (OsHV-1) |
topic_facet |
Crassostrea gigas OsHV-1 transgenerational immune priming trained immunity RNA-seq |
description |
The oyster's immune system is capable of adapting upon exposure to a pathogen-associated molecular pattern (PAMP) to have an enhanced secondary response against the same type of pathogen. This has been demonstrated using poly(I:C) to elicit an antiviral response in the Pacific oyster ( Crassostrea gigas ) against Ostreid herpesvirus (OsHV-1). Improved survival following exposure to poly(I:C) has been found in later life stages (within-generational immune priming) and in the next generation (transgenerational immune priming). The mechanism that the oyster uses to transfer immunity to the next generation is unknown. Here we show that oyster larvae have higher survival to OsHV-1 when their mothers, but not their fathers, are exposed to poly(I:C) prior to spawning. RNA-seq provided no evidence to suggest that parental exposure to poly(I:C) reconfigures antiviral gene expression in unchallenged larvae. We conclude that the improved survival of larvae might occur via maternal provisioning of antiviral compounds in the eggs. |
format |
Article in Journal/Newspaper |
author |
Lafont, Maxime Goncalves, Priscila Guo, Ximing Montagnani, Caroline Raftos, David Green, Timothy |
author_facet |
Lafont, Maxime Goncalves, Priscila Guo, Ximing Montagnani, Caroline Raftos, David Green, Timothy |
author_sort |
Lafont, Maxime |
title |
Transgenerational plasticity and antiviral immunity in the Pacific oyster ( Crassostrea gigas ) against Ostreid herpesvirus 1 (OsHV-1) |
title_short |
Transgenerational plasticity and antiviral immunity in the Pacific oyster ( Crassostrea gigas ) against Ostreid herpesvirus 1 (OsHV-1) |
title_full |
Transgenerational plasticity and antiviral immunity in the Pacific oyster ( Crassostrea gigas ) against Ostreid herpesvirus 1 (OsHV-1) |
title_fullStr |
Transgenerational plasticity and antiviral immunity in the Pacific oyster ( Crassostrea gigas ) against Ostreid herpesvirus 1 (OsHV-1) |
title_full_unstemmed |
Transgenerational plasticity and antiviral immunity in the Pacific oyster ( Crassostrea gigas ) against Ostreid herpesvirus 1 (OsHV-1) |
title_sort |
transgenerational plasticity and antiviral immunity in the pacific oyster ( crassostrea gigas ) against ostreid herpesvirus 1 (oshv-1) |
publishDate |
2019 |
url |
https://researchers.mq.edu.au/en/publications/60d0a282-5e72-45a6-9937-df724072299c https://doi.org/10.1016/j.dci.2018.09.022 http://www.scopus.com/inward/record.url?scp=85056176022&partnerID=8YFLogxK |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_source |
Lafont , M , Goncalves , P , Guo , X , Montagnani , C , Raftos , D & Green , T 2019 , ' Transgenerational plasticity and antiviral immunity in the Pacific oyster ( Crassostrea gigas ) against Ostreid herpesvirus 1 (OsHV-1) ' , Developmental and Comparative Immunology , vol. 91 , pp. 17-25 . https://doi.org/10.1016/j.dci.2018.09.022 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1016/j.dci.2018.09.022 |
container_title |
Developmental & Comparative Immunology |
container_volume |
91 |
container_start_page |
17 |
op_container_end_page |
25 |
_version_ |
1800750427881340928 |