Robust and prototypical immune responses toward COVID-19 vaccine in First Nations peoples are impacted by comorbidities
High-risk groups, including Indigenous people, are at risk of severe COVID-19. Here we found that Australian First Nations peoples elicit effective immune responses to COVID-19 BNT162b2 vaccination, including neutralizing antibodies, receptor-binding domain (RBD) antibodies, SARS-CoV-2 spike-specifi...
Published in: | Nature Immunology |
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2023
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Online Access: | https://researchers.mq.edu.au/en/publications/50367f98-c810-457b-b27f-7c662eb6a243 https://doi.org/10.1038/s41590-023-01508-y https://research-management.mq.edu.au/ws/files/345335748/Publisher_version_open_access_.pdf http://www.scopus.com/inward/record.url?scp=85160428645&partnerID=8YFLogxK |
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ftmacquarieunicr:oai:https://researchers.mq.edu.au:publications/50367f98-c810-457b-b27f-7c662eb6a243 2024-09-15T18:06:23+00:00 Robust and prototypical immune responses toward COVID-19 vaccine in First Nations peoples are impacted by comorbidities Zhang, Wuji Kedzierski, Lukasz Chua, Brendon Y. Mayo, Mark Lonzi, Claire Rigas, Vanessa Middleton, Bianca F. McQuilten, Hayley A. Rowntree, Louise C. Allen, Lilith F. Purcell, Ruth A. Tan, Hyon Xhi Petersen, Jan Chaurasia, Priyanka Mordant, Francesca Pogorelyy, Mikhail V. Minervina, Anastasia A. Crawford, Jeremy Chase Perkins, Griffith B. Zhang, Eva Gras, Stephanie Clemens, E. Bridie Juno, Jennifer A. Audsley, Jennifer Khoury, David S. Holmes, Natasha E. Thevarajan, Irani Subbarao, Kanta Krammer, Florian Cheng, Allen C. Davenport, Miles P. Grubor-Bauk, Branka Coates, P. Toby Christensen, Britt Thomas, Paul G. Wheatley, Adam K. Kent, Stephen J. Rossjohn, Jamie Chung, Amy W. Boffa, John Miller, Adrian Lynar, Sarah Nelson, Jane Nguyen, Thi H.O. Davies, Jane Kedzierska, Katherine 2023-06 application/pdf https://researchers.mq.edu.au/en/publications/50367f98-c810-457b-b27f-7c662eb6a243 https://doi.org/10.1038/s41590-023-01508-y https://research-management.mq.edu.au/ws/files/345335748/Publisher_version_open_access_.pdf http://www.scopus.com/inward/record.url?scp=85160428645&partnerID=8YFLogxK eng eng info:eu-repo/semantics/openAccess Zhang , W , Kedzierski , L , Chua , B Y , Mayo , M , Lonzi , C , Rigas , V , Middleton , B F , McQuilten , H A , Rowntree , L C , Allen , L F , Purcell , R A , Tan , H X , Petersen , J , Chaurasia , P , Mordant , F , Pogorelyy , M V , Minervina , A A , Crawford , J C , Perkins , G B , Zhang , E , Gras , S , Clemens , E B , Juno , J A , Audsley , J , Khoury , D S , Holmes , N E , Thevarajan , I , Subbarao , K , Krammer , F , Cheng , A C , Davenport , M P , Grubor-Bauk , B , Coates , P T , Christensen , B , Thomas , P G , Wheatley , A K , Kent , S J , Rossjohn , J , Chung , A W , Boffa , J , Miller , A , Lynar , S , Nelson , J , Nguyen , T H O , Davies , J & Kedzierska , K 2023 , ' Robust and prototypical immune responses toward COVID-19 vaccine in First Nations peoples are impacted by comorbidities ' , Nature Immunology , vol. 24 , no. 6 , pp. 966-978 . https://doi.org/10.1038/s41590-023-01508-y article 2023 ftmacquarieunicr https://doi.org/10.1038/s41590-023-01508-y 2024-09-04T23:52:02Z High-risk groups, including Indigenous people, are at risk of severe COVID-19. Here we found that Australian First Nations peoples elicit effective immune responses to COVID-19 BNT162b2 vaccination, including neutralizing antibodies, receptor-binding domain (RBD) antibodies, SARS-CoV-2 spike-specific B cells, and CD4 + and CD8 + T cells. In First Nations participants, RBD IgG antibody titers were correlated with body mass index and negatively correlated with age. Reduced RBD antibodies, spike-specific B cells and follicular helper T cells were found in vaccinated participants with chronic conditions (diabetes, renal disease) and were strongly associated with altered glycosylation of IgG and increased interleukin-18 levels in the plasma. These immune perturbations were also found in non-Indigenous people with comorbidities, indicating that they were related to comorbidities rather than ethnicity. However, our study is of a great importance to First Nations peoples who have disproportionate rates of chronic comorbidities and provides evidence of robust immune responses after COVID-19 vaccination in Indigenous people. Article in Journal/Newspaper First Nations Macquarie University Research Portal Nature Immunology 24 6 966 978 |
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Macquarie University Research Portal |
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description |
High-risk groups, including Indigenous people, are at risk of severe COVID-19. Here we found that Australian First Nations peoples elicit effective immune responses to COVID-19 BNT162b2 vaccination, including neutralizing antibodies, receptor-binding domain (RBD) antibodies, SARS-CoV-2 spike-specific B cells, and CD4 + and CD8 + T cells. In First Nations participants, RBD IgG antibody titers were correlated with body mass index and negatively correlated with age. Reduced RBD antibodies, spike-specific B cells and follicular helper T cells were found in vaccinated participants with chronic conditions (diabetes, renal disease) and were strongly associated with altered glycosylation of IgG and increased interleukin-18 levels in the plasma. These immune perturbations were also found in non-Indigenous people with comorbidities, indicating that they were related to comorbidities rather than ethnicity. However, our study is of a great importance to First Nations peoples who have disproportionate rates of chronic comorbidities and provides evidence of robust immune responses after COVID-19 vaccination in Indigenous people. |
format |
Article in Journal/Newspaper |
author |
Zhang, Wuji Kedzierski, Lukasz Chua, Brendon Y. Mayo, Mark Lonzi, Claire Rigas, Vanessa Middleton, Bianca F. McQuilten, Hayley A. Rowntree, Louise C. Allen, Lilith F. Purcell, Ruth A. Tan, Hyon Xhi Petersen, Jan Chaurasia, Priyanka Mordant, Francesca Pogorelyy, Mikhail V. Minervina, Anastasia A. Crawford, Jeremy Chase Perkins, Griffith B. Zhang, Eva Gras, Stephanie Clemens, E. Bridie Juno, Jennifer A. Audsley, Jennifer Khoury, David S. Holmes, Natasha E. Thevarajan, Irani Subbarao, Kanta Krammer, Florian Cheng, Allen C. Davenport, Miles P. Grubor-Bauk, Branka Coates, P. Toby Christensen, Britt Thomas, Paul G. Wheatley, Adam K. Kent, Stephen J. Rossjohn, Jamie Chung, Amy W. Boffa, John Miller, Adrian Lynar, Sarah Nelson, Jane Nguyen, Thi H.O. Davies, Jane Kedzierska, Katherine |
spellingShingle |
Zhang, Wuji Kedzierski, Lukasz Chua, Brendon Y. Mayo, Mark Lonzi, Claire Rigas, Vanessa Middleton, Bianca F. McQuilten, Hayley A. Rowntree, Louise C. Allen, Lilith F. Purcell, Ruth A. Tan, Hyon Xhi Petersen, Jan Chaurasia, Priyanka Mordant, Francesca Pogorelyy, Mikhail V. Minervina, Anastasia A. Crawford, Jeremy Chase Perkins, Griffith B. Zhang, Eva Gras, Stephanie Clemens, E. Bridie Juno, Jennifer A. Audsley, Jennifer Khoury, David S. Holmes, Natasha E. Thevarajan, Irani Subbarao, Kanta Krammer, Florian Cheng, Allen C. Davenport, Miles P. Grubor-Bauk, Branka Coates, P. Toby Christensen, Britt Thomas, Paul G. Wheatley, Adam K. Kent, Stephen J. Rossjohn, Jamie Chung, Amy W. Boffa, John Miller, Adrian Lynar, Sarah Nelson, Jane Nguyen, Thi H.O. Davies, Jane Kedzierska, Katherine Robust and prototypical immune responses toward COVID-19 vaccine in First Nations peoples are impacted by comorbidities |
author_facet |
Zhang, Wuji Kedzierski, Lukasz Chua, Brendon Y. Mayo, Mark Lonzi, Claire Rigas, Vanessa Middleton, Bianca F. McQuilten, Hayley A. Rowntree, Louise C. Allen, Lilith F. Purcell, Ruth A. Tan, Hyon Xhi Petersen, Jan Chaurasia, Priyanka Mordant, Francesca Pogorelyy, Mikhail V. Minervina, Anastasia A. Crawford, Jeremy Chase Perkins, Griffith B. Zhang, Eva Gras, Stephanie Clemens, E. Bridie Juno, Jennifer A. Audsley, Jennifer Khoury, David S. Holmes, Natasha E. Thevarajan, Irani Subbarao, Kanta Krammer, Florian Cheng, Allen C. Davenport, Miles P. Grubor-Bauk, Branka Coates, P. Toby Christensen, Britt Thomas, Paul G. Wheatley, Adam K. Kent, Stephen J. Rossjohn, Jamie Chung, Amy W. Boffa, John Miller, Adrian Lynar, Sarah Nelson, Jane Nguyen, Thi H.O. Davies, Jane Kedzierska, Katherine |
author_sort |
Zhang, Wuji |
title |
Robust and prototypical immune responses toward COVID-19 vaccine in First Nations peoples are impacted by comorbidities |
title_short |
Robust and prototypical immune responses toward COVID-19 vaccine in First Nations peoples are impacted by comorbidities |
title_full |
Robust and prototypical immune responses toward COVID-19 vaccine in First Nations peoples are impacted by comorbidities |
title_fullStr |
Robust and prototypical immune responses toward COVID-19 vaccine in First Nations peoples are impacted by comorbidities |
title_full_unstemmed |
Robust and prototypical immune responses toward COVID-19 vaccine in First Nations peoples are impacted by comorbidities |
title_sort |
robust and prototypical immune responses toward covid-19 vaccine in first nations peoples are impacted by comorbidities |
publishDate |
2023 |
url |
https://researchers.mq.edu.au/en/publications/50367f98-c810-457b-b27f-7c662eb6a243 https://doi.org/10.1038/s41590-023-01508-y https://research-management.mq.edu.au/ws/files/345335748/Publisher_version_open_access_.pdf http://www.scopus.com/inward/record.url?scp=85160428645&partnerID=8YFLogxK |
genre |
First Nations |
genre_facet |
First Nations |
op_source |
Zhang , W , Kedzierski , L , Chua , B Y , Mayo , M , Lonzi , C , Rigas , V , Middleton , B F , McQuilten , H A , Rowntree , L C , Allen , L F , Purcell , R A , Tan , H X , Petersen , J , Chaurasia , P , Mordant , F , Pogorelyy , M V , Minervina , A A , Crawford , J C , Perkins , G B , Zhang , E , Gras , S , Clemens , E B , Juno , J A , Audsley , J , Khoury , D S , Holmes , N E , Thevarajan , I , Subbarao , K , Krammer , F , Cheng , A C , Davenport , M P , Grubor-Bauk , B , Coates , P T , Christensen , B , Thomas , P G , Wheatley , A K , Kent , S J , Rossjohn , J , Chung , A W , Boffa , J , Miller , A , Lynar , S , Nelson , J , Nguyen , T H O , Davies , J & Kedzierska , K 2023 , ' Robust and prototypical immune responses toward COVID-19 vaccine in First Nations peoples are impacted by comorbidities ' , Nature Immunology , vol. 24 , no. 6 , pp. 966-978 . https://doi.org/10.1038/s41590-023-01508-y |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1038/s41590-023-01508-y |
container_title |
Nature Immunology |
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24 |
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6 |
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966 |
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978 |
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1810443831073570816 |