Adipose gene expression profiles reveal insights into the adaptation of northern Eurasian semi-domestic reindeer (Rangifer tarandus)
Reindeer (Rangifer tarandus) are semi-domesticated animals adapted to the challenging conditions of northern Eurasia. Adipose tissues play a crucial role in northern animals by altering gene expression in their tissues to regulate energy homoeostasis and thermogenic activity. Here, we perform transc...
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ftluke:oai:jukuri.luke.fi:10024/547930 2023-10-09T21:49:07+02:00 Adipose gene expression profiles reveal insights into the adaptation of northern Eurasian semi-domestic reindeer (Rangifer tarandus) Weldenegodguad, Melak Pokharel, Kisun Niiranen, Laura Soppela, Päivi Ammosov, Innokentyi Honkatukia, Mervi Lindeberg, Heli Peippo, Jaana Reilas, Tiina Mazzullo, Nuccio Mäkelä, Kari A. Nyman, Tommi Tervahauta, Arja Herzig, Karl-Heinz Stammler, Florian Kantanen, Juha orcid:0000-0002-2876-6353 orcid:0000-0002-4924-946X orcid:0000-0002-5841-2898 orcid:0000-0003-2548-7700 orcid:0000-0001-6350-6373 4100111010 4100211610 Luonnonvarakeskus 13 p. true https://jukuri.luke.fi/handle/10024/547930 en eng Springer Nature Communications biology 10.1038/s42003-021-02703-z 2399-3642 1 4 1170 https://jukuri.luke.fi/handle/10024/547930 URN:NBN:fi-fe2021100850411 CC BY 4.0 poro genomiikka RNA rasvakudokset sopeutuminen reindeer genomics adipose tissues adaptations publication fi=A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä|sv=A1 Originalartikel i en vetenskaplig tidskrift|en=A1 Journal article (refereed), original research| fi=Publisher's version|sv=Publisher's version|en=Publisher's version| ftluke 2023-09-12T20:28:04Z Reindeer (Rangifer tarandus) are semi-domesticated animals adapted to the challenging conditions of northern Eurasia. Adipose tissues play a crucial role in northern animals by altering gene expression in their tissues to regulate energy homoeostasis and thermogenic activity. Here, we perform transcriptome profiling by RNA sequencing of adipose tissues from three different anatomical depots: metacarpal (bone marrow), perirenal, and prescapular fat in Finnish and Even reindeer (in Sakha) during spring and winter. A total of 16,212 genes are expressed in our data. Gene expression profiles in metacarpal tissue are distinct from perirenal and prescapular adipose tissues. Notably, metacarpal adipose tissue appears to have a significant role in the regulation of the energy metabolism of reindeer in spring when their nutritional condition is poor after winter. During spring, genes associated with the immune system are upregulated in the perirenal and prescapular adipose tissue. Blood and tissue parameters reflecting general physiological and metabolic status show less seasonal variation in Even reindeer than in Finnish reindeer. This study identifies candidate genes potentially involved in immune response, fat deposition, and energy metabolism and provides new information on the mechanisms by which reindeer adapt to harsh arctic conditions. 2021 Article in Journal/Newspaper Arctic Rangifer tarandus Natural Resources Institute Finland: Jukuri Arctic Sakha |
institution |
Open Polar |
collection |
Natural Resources Institute Finland: Jukuri |
op_collection_id |
ftluke |
language |
English |
topic |
poro genomiikka RNA rasvakudokset sopeutuminen reindeer genomics adipose tissues adaptations |
spellingShingle |
poro genomiikka RNA rasvakudokset sopeutuminen reindeer genomics adipose tissues adaptations Weldenegodguad, Melak Pokharel, Kisun Niiranen, Laura Soppela, Päivi Ammosov, Innokentyi Honkatukia, Mervi Lindeberg, Heli Peippo, Jaana Reilas, Tiina Mazzullo, Nuccio Mäkelä, Kari A. Nyman, Tommi Tervahauta, Arja Herzig, Karl-Heinz Stammler, Florian Kantanen, Juha Adipose gene expression profiles reveal insights into the adaptation of northern Eurasian semi-domestic reindeer (Rangifer tarandus) |
topic_facet |
poro genomiikka RNA rasvakudokset sopeutuminen reindeer genomics adipose tissues adaptations |
description |
Reindeer (Rangifer tarandus) are semi-domesticated animals adapted to the challenging conditions of northern Eurasia. Adipose tissues play a crucial role in northern animals by altering gene expression in their tissues to regulate energy homoeostasis and thermogenic activity. Here, we perform transcriptome profiling by RNA sequencing of adipose tissues from three different anatomical depots: metacarpal (bone marrow), perirenal, and prescapular fat in Finnish and Even reindeer (in Sakha) during spring and winter. A total of 16,212 genes are expressed in our data. Gene expression profiles in metacarpal tissue are distinct from perirenal and prescapular adipose tissues. Notably, metacarpal adipose tissue appears to have a significant role in the regulation of the energy metabolism of reindeer in spring when their nutritional condition is poor after winter. During spring, genes associated with the immune system are upregulated in the perirenal and prescapular adipose tissue. Blood and tissue parameters reflecting general physiological and metabolic status show less seasonal variation in Even reindeer than in Finnish reindeer. This study identifies candidate genes potentially involved in immune response, fat deposition, and energy metabolism and provides new information on the mechanisms by which reindeer adapt to harsh arctic conditions. 2021 |
author2 |
orcid:0000-0002-2876-6353 orcid:0000-0002-4924-946X orcid:0000-0002-5841-2898 orcid:0000-0003-2548-7700 orcid:0000-0001-6350-6373 4100111010 4100211610 Luonnonvarakeskus |
format |
Article in Journal/Newspaper |
author |
Weldenegodguad, Melak Pokharel, Kisun Niiranen, Laura Soppela, Päivi Ammosov, Innokentyi Honkatukia, Mervi Lindeberg, Heli Peippo, Jaana Reilas, Tiina Mazzullo, Nuccio Mäkelä, Kari A. Nyman, Tommi Tervahauta, Arja Herzig, Karl-Heinz Stammler, Florian Kantanen, Juha |
author_facet |
Weldenegodguad, Melak Pokharel, Kisun Niiranen, Laura Soppela, Päivi Ammosov, Innokentyi Honkatukia, Mervi Lindeberg, Heli Peippo, Jaana Reilas, Tiina Mazzullo, Nuccio Mäkelä, Kari A. Nyman, Tommi Tervahauta, Arja Herzig, Karl-Heinz Stammler, Florian Kantanen, Juha |
author_sort |
Weldenegodguad, Melak |
title |
Adipose gene expression profiles reveal insights into the adaptation of northern Eurasian semi-domestic reindeer (Rangifer tarandus) |
title_short |
Adipose gene expression profiles reveal insights into the adaptation of northern Eurasian semi-domestic reindeer (Rangifer tarandus) |
title_full |
Adipose gene expression profiles reveal insights into the adaptation of northern Eurasian semi-domestic reindeer (Rangifer tarandus) |
title_fullStr |
Adipose gene expression profiles reveal insights into the adaptation of northern Eurasian semi-domestic reindeer (Rangifer tarandus) |
title_full_unstemmed |
Adipose gene expression profiles reveal insights into the adaptation of northern Eurasian semi-domestic reindeer (Rangifer tarandus) |
title_sort |
adipose gene expression profiles reveal insights into the adaptation of northern eurasian semi-domestic reindeer (rangifer tarandus) |
publisher |
Springer Nature |
url |
https://jukuri.luke.fi/handle/10024/547930 |
geographic |
Arctic Sakha |
geographic_facet |
Arctic Sakha |
genre |
Arctic Rangifer tarandus |
genre_facet |
Arctic Rangifer tarandus |
op_relation |
Communications biology 10.1038/s42003-021-02703-z 2399-3642 1 4 1170 https://jukuri.luke.fi/handle/10024/547930 URN:NBN:fi-fe2021100850411 |
op_rights |
CC BY 4.0 |
_version_ |
1779312139948785664 |