Rodent host population dynamics drive zoonotic Lyme Borreliosis and Orthohantavirus infections in humans in Northern Europe
Zoonotic diseases, caused by pathogens transmitted between other vertebrate animals and humans, pose a major risk to human health. Rodents are important reservoir hosts for many zoonotic pathogens, and rodent population dynamics affect the infection dynamics of rodent-borne diseases, such as disease...
Main Authors: | , , , , , , , |
---|---|
Other Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Nature Publishing Group
|
Subjects: | |
Online Access: | https://jukuri.luke.fi/handle/10024/547762 |
id |
ftluke:oai:jukuri.luke.fi:10024/547762 |
---|---|
record_format |
openpolar |
spelling |
ftluke:oai:jukuri.luke.fi:10024/547762 2023-10-09T21:51:26+02:00 Rodent host population dynamics drive zoonotic Lyme Borreliosis and Orthohantavirus infections in humans in Northern Europe Aminikhah, Mahdi Forsman, Jukka T. Koskela, Esa Mappes, Tapio Sane, Jussi Ollgren, Jukka Kivelä, Sami M. Kallio, Eva R. orcid:0000-0002-4156-7930 4100110810 Luonnonvarakeskus 11 p. true https://jukuri.luke.fi/handle/10024/547762 en eng Nature Publishing Group Scientific reports 10.1038/s41598-021-95000-y 2045-2322 1 11 16128 https://jukuri.luke.fi/handle/10024/547762 URN:NBN:fi-fe2021081643318 CC BY 4.0 zoonoosit zoology Borrelia Lymen borrelioosi hantavirukset publication fi=A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä|sv=A1 Originalartikel i en vetenskaplig tidskrift|en=A1 Journal article (refereed), original research| fi=Publisher's version|sv=Publisher's version|en=Publisher's version| ftluke 2023-09-12T20:28:01Z Zoonotic diseases, caused by pathogens transmitted between other vertebrate animals and humans, pose a major risk to human health. Rodents are important reservoir hosts for many zoonotic pathogens, and rodent population dynamics affect the infection dynamics of rodent-borne diseases, such as diseases caused by hantaviruses. However, the role of rodent population dynamics in determining the infection dynamics of rodent-associated tick-borne diseases, such as Lyme borreliosis (LB), caused by Borrelia burgdorferi sensu lato bacteria, have gained limited attention in Northern Europe, despite the multiannual abundance fluctuations, the so-called vole cycles, that characterise rodent population dynamics in the region. Here, we quantify the associations between rodent abundance and LB human cases and Puumala Orthohantavirus (PUUV) infections by using two time series (25-year and 9-year) in Finland. Both bank vole (Myodes glareolus) abundance as well as LB and PUUV infection incidence in humans showed approximately 3-year cycles. Without vector transmitted PUUV infections followed the bank vole host abundance fluctuations with two-month time lag, whereas tick-transmitted LB was associated with bank vole abundance ca. 12 and 24 months earlier. However, the strength of association between LB incidence and bank vole abundance ca. 12 months before varied over the study years. This study highlights that the human risk to acquire rodent-borne pathogens, as well as rodent-associated tick-borne pathogens is associated with the vole cycles in Northern Fennoscandia, yet with complex time lags. 2021 Article in Journal/Newspaper Fennoscandia Natural Resources Institute Finland: Jukuri |
institution |
Open Polar |
collection |
Natural Resources Institute Finland: Jukuri |
op_collection_id |
ftluke |
language |
English |
topic |
zoonoosit zoology Borrelia Lymen borrelioosi hantavirukset |
spellingShingle |
zoonoosit zoology Borrelia Lymen borrelioosi hantavirukset Aminikhah, Mahdi Forsman, Jukka T. Koskela, Esa Mappes, Tapio Sane, Jussi Ollgren, Jukka Kivelä, Sami M. Kallio, Eva R. Rodent host population dynamics drive zoonotic Lyme Borreliosis and Orthohantavirus infections in humans in Northern Europe |
topic_facet |
zoonoosit zoology Borrelia Lymen borrelioosi hantavirukset |
description |
Zoonotic diseases, caused by pathogens transmitted between other vertebrate animals and humans, pose a major risk to human health. Rodents are important reservoir hosts for many zoonotic pathogens, and rodent population dynamics affect the infection dynamics of rodent-borne diseases, such as diseases caused by hantaviruses. However, the role of rodent population dynamics in determining the infection dynamics of rodent-associated tick-borne diseases, such as Lyme borreliosis (LB), caused by Borrelia burgdorferi sensu lato bacteria, have gained limited attention in Northern Europe, despite the multiannual abundance fluctuations, the so-called vole cycles, that characterise rodent population dynamics in the region. Here, we quantify the associations between rodent abundance and LB human cases and Puumala Orthohantavirus (PUUV) infections by using two time series (25-year and 9-year) in Finland. Both bank vole (Myodes glareolus) abundance as well as LB and PUUV infection incidence in humans showed approximately 3-year cycles. Without vector transmitted PUUV infections followed the bank vole host abundance fluctuations with two-month time lag, whereas tick-transmitted LB was associated with bank vole abundance ca. 12 and 24 months earlier. However, the strength of association between LB incidence and bank vole abundance ca. 12 months before varied over the study years. This study highlights that the human risk to acquire rodent-borne pathogens, as well as rodent-associated tick-borne pathogens is associated with the vole cycles in Northern Fennoscandia, yet with complex time lags. 2021 |
author2 |
orcid:0000-0002-4156-7930 4100110810 Luonnonvarakeskus |
format |
Article in Journal/Newspaper |
author |
Aminikhah, Mahdi Forsman, Jukka T. Koskela, Esa Mappes, Tapio Sane, Jussi Ollgren, Jukka Kivelä, Sami M. Kallio, Eva R. |
author_facet |
Aminikhah, Mahdi Forsman, Jukka T. Koskela, Esa Mappes, Tapio Sane, Jussi Ollgren, Jukka Kivelä, Sami M. Kallio, Eva R. |
author_sort |
Aminikhah, Mahdi |
title |
Rodent host population dynamics drive zoonotic Lyme Borreliosis and Orthohantavirus infections in humans in Northern Europe |
title_short |
Rodent host population dynamics drive zoonotic Lyme Borreliosis and Orthohantavirus infections in humans in Northern Europe |
title_full |
Rodent host population dynamics drive zoonotic Lyme Borreliosis and Orthohantavirus infections in humans in Northern Europe |
title_fullStr |
Rodent host population dynamics drive zoonotic Lyme Borreliosis and Orthohantavirus infections in humans in Northern Europe |
title_full_unstemmed |
Rodent host population dynamics drive zoonotic Lyme Borreliosis and Orthohantavirus infections in humans in Northern Europe |
title_sort |
rodent host population dynamics drive zoonotic lyme borreliosis and orthohantavirus infections in humans in northern europe |
publisher |
Nature Publishing Group |
url |
https://jukuri.luke.fi/handle/10024/547762 |
genre |
Fennoscandia |
genre_facet |
Fennoscandia |
op_relation |
Scientific reports 10.1038/s41598-021-95000-y 2045-2322 1 11 16128 https://jukuri.luke.fi/handle/10024/547762 URN:NBN:fi-fe2021081643318 |
op_rights |
CC BY 4.0 |
_version_ |
1779314539303534592 |