Sequence variant on 8q24 confers susceptibility to urinary bladder cancer.
We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in seven additional case-control groups (2,165 cases and 3,800 controls). The strongest association was observed with allele T of rs...
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Online Access: | https://researchonline.lshtm.ac.uk/id/eprint/6594/ |
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ftlshtm:oai:researchonline.lshtm.ac.uk:6594 2023-05-15T16:49:26+02:00 Sequence variant on 8q24 confers susceptibility to urinary bladder cancer. Kiemeney, Lambertus A Thorlacius, Steinunn Sulem, Patrick Geller, Frank Aben, Katja KH Stacey, Simon N Gudmundsson, Julius Jakobsdottir, Margret Bergthorsson, Jon T Sigurdsson, Asgeir Blondal, Thorarinn Witjes, J Alfred Vermeulen, Sita H Hulsbergen-van de Kaa, Christina A Swinkels, Dorine W Ploeg, Martine Cornel, Erik B Vergunst, Henk Thorgeirsson, Thorgeir E Gudbjartsson, Daniel Gudjonsson, Sigurjon A Thorleifsson, Gudmar Kristinsson, Kari T Mouy, Magali Snorradottir, Steinunn Placidi, Donatella Campagna, Marcello Arici, Cecilia Koppova, Kvetoslava Gurzau, Eugene Rudnai, Peter Kellen, Eliane Polidoro, Silvia Guarrera, Simonetta Sacerdote, Carlotta Sanchez, Manuel Saez, Berta Valdivia, Gabriel Ryk, Charlotta de Verdier, Petra Lindblom, Annika Golka, Klaus Bishop, D Timothy Knowles, Margaret A Nikulasson, Sigfus Petursdottir, Vigdis Jonsson, Eirikur Geirsson, Gudmundur Kristjansson, Baldvin Mayordomo, Jose I Steineck, Gunnar Porru, Stefano Buntinx, Frank Zeegers, Maurice P Fletcher, Tony Kumar, Rajiv Matullo, Giuseppe Vineis, Paolo Kiltie, Anne E Gulcher, Jeffrey R Thorsteinsdottir, Unnur Kong, Augustine Rafnar, Thorunn Stefansson, Kari 2008 https://researchonline.lshtm.ac.uk/id/eprint/6594/ unknown Nature Research Kiemeney, Lambertus A; Thorlacius, Steinunn; Sulem, Patrick; Geller, Frank; Aben, Katja KH; Stacey, Simon N; Gudmundsson, Julius; Jakobsdottir, Margret; Bergthorsson, Jon T; Sigurdsson, Asgeir; +54 more. Blondal, Thorarinn; Witjes, J Alfred; Vermeulen, Sita H; Hulsbergen-van de Kaa, Christina A; Swinkels, Dorine W; Ploeg, Martine; Cornel, Erik B; Vergunst, Henk; Thorgeirsson, Thorgeir E; Gudbjartsson, Daniel; Gudjonsson, Sigurjon A; Thorleifsson, Gudmar; Kristinsson, Kari T; Mouy, Magali; Snorradottir, Steinunn; Placidi, Donatella; Campagna, Marcello; Arici, Cecilia; Koppova, Kvetoslava; Gurzau, Eugene; Rudnai, Peter; Kellen, Eliane; Polidoro, Silvia; Guarrera, Simonetta; Sacerdote, Carlotta; Sanchez, Manuel; Saez, Berta; Valdivia, Gabriel; Ryk, Charlotta; de Verdier, Petra; Lindblom, Annika; Golka, Klaus; Bishop, D Timothy; Knowles, Margaret A; Nikulasson, Sigfus; Petursdottir, Vigdis; Jonsson, Eirikur; Geirsson, Gudmundur; Kristjansson, Baldvin; Mayordomo, Jose I; Steineck, Gunnar; Porru, Stefano; Buntinx, Frank; Zeegers, Maurice P; Fletcher, Tony <https://researchonline.lshtm.ac.uk/view/creators/ppehtfle.html>; Kumar, Rajiv; Matullo, Giuseppe; Vineis, Paolo; Kiltie, Anne E; Gulcher, Jeffrey R; Thorsteinsdottir, Unnur; Kong, Augustine; Rafnar, Thorunn; Stefansson, Kari; (2008) Sequence variant on 8q24 confers susceptibility to urinary bladder cancer. Nature genetics, 40 (11). pp. 1307-1312. ISSN 1061-4036 DOI: https://doi.org/10.1038/ng.229 <https://doi.org/10.1038/ng.229> Article PeerReviewed 2008 ftlshtm https://doi.org/10.1038/ng.229 2022-03-03T06:39:48Z We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in seven additional case-control groups (2,165 cases and 3,800 controls). The strongest association was observed with allele T of rs9642880 on chromosome 8q24, 30 kb upstream of MYC (allele-specific odds ratio (OR) = 1.22; P = 9.34 x 10(-12)). Approximately 20% of individuals of European ancestry are homozygous for rs9642880[T], and their estimated risk of developing UBC is 1.49 times that of noncarriers. No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any of these three cancers. A weaker signal, but nonetheless of genome-wide significance, was captured by rs710521[A] located near TP63 on chromosome 3q28 (allele-specific OR = 1.19; P = 1. 15 x 10(-7)). Article in Journal/Newspaper Iceland London School of Hygiene & Tropical Medicine: LSHTM Research Online Nature Genetics 40 11 1307 1312 |
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London School of Hygiene & Tropical Medicine: LSHTM Research Online |
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We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in seven additional case-control groups (2,165 cases and 3,800 controls). The strongest association was observed with allele T of rs9642880 on chromosome 8q24, 30 kb upstream of MYC (allele-specific odds ratio (OR) = 1.22; P = 9.34 x 10(-12)). Approximately 20% of individuals of European ancestry are homozygous for rs9642880[T], and their estimated risk of developing UBC is 1.49 times that of noncarriers. No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any of these three cancers. A weaker signal, but nonetheless of genome-wide significance, was captured by rs710521[A] located near TP63 on chromosome 3q28 (allele-specific OR = 1.19; P = 1. 15 x 10(-7)). |
format |
Article in Journal/Newspaper |
author |
Kiemeney, Lambertus A Thorlacius, Steinunn Sulem, Patrick Geller, Frank Aben, Katja KH Stacey, Simon N Gudmundsson, Julius Jakobsdottir, Margret Bergthorsson, Jon T Sigurdsson, Asgeir Blondal, Thorarinn Witjes, J Alfred Vermeulen, Sita H Hulsbergen-van de Kaa, Christina A Swinkels, Dorine W Ploeg, Martine Cornel, Erik B Vergunst, Henk Thorgeirsson, Thorgeir E Gudbjartsson, Daniel Gudjonsson, Sigurjon A Thorleifsson, Gudmar Kristinsson, Kari T Mouy, Magali Snorradottir, Steinunn Placidi, Donatella Campagna, Marcello Arici, Cecilia Koppova, Kvetoslava Gurzau, Eugene Rudnai, Peter Kellen, Eliane Polidoro, Silvia Guarrera, Simonetta Sacerdote, Carlotta Sanchez, Manuel Saez, Berta Valdivia, Gabriel Ryk, Charlotta de Verdier, Petra Lindblom, Annika Golka, Klaus Bishop, D Timothy Knowles, Margaret A Nikulasson, Sigfus Petursdottir, Vigdis Jonsson, Eirikur Geirsson, Gudmundur Kristjansson, Baldvin Mayordomo, Jose I Steineck, Gunnar Porru, Stefano Buntinx, Frank Zeegers, Maurice P Fletcher, Tony Kumar, Rajiv Matullo, Giuseppe Vineis, Paolo Kiltie, Anne E Gulcher, Jeffrey R Thorsteinsdottir, Unnur Kong, Augustine Rafnar, Thorunn Stefansson, Kari |
spellingShingle |
Kiemeney, Lambertus A Thorlacius, Steinunn Sulem, Patrick Geller, Frank Aben, Katja KH Stacey, Simon N Gudmundsson, Julius Jakobsdottir, Margret Bergthorsson, Jon T Sigurdsson, Asgeir Blondal, Thorarinn Witjes, J Alfred Vermeulen, Sita H Hulsbergen-van de Kaa, Christina A Swinkels, Dorine W Ploeg, Martine Cornel, Erik B Vergunst, Henk Thorgeirsson, Thorgeir E Gudbjartsson, Daniel Gudjonsson, Sigurjon A Thorleifsson, Gudmar Kristinsson, Kari T Mouy, Magali Snorradottir, Steinunn Placidi, Donatella Campagna, Marcello Arici, Cecilia Koppova, Kvetoslava Gurzau, Eugene Rudnai, Peter Kellen, Eliane Polidoro, Silvia Guarrera, Simonetta Sacerdote, Carlotta Sanchez, Manuel Saez, Berta Valdivia, Gabriel Ryk, Charlotta de Verdier, Petra Lindblom, Annika Golka, Klaus Bishop, D Timothy Knowles, Margaret A Nikulasson, Sigfus Petursdottir, Vigdis Jonsson, Eirikur Geirsson, Gudmundur Kristjansson, Baldvin Mayordomo, Jose I Steineck, Gunnar Porru, Stefano Buntinx, Frank Zeegers, Maurice P Fletcher, Tony Kumar, Rajiv Matullo, Giuseppe Vineis, Paolo Kiltie, Anne E Gulcher, Jeffrey R Thorsteinsdottir, Unnur Kong, Augustine Rafnar, Thorunn Stefansson, Kari Sequence variant on 8q24 confers susceptibility to urinary bladder cancer. |
author_facet |
Kiemeney, Lambertus A Thorlacius, Steinunn Sulem, Patrick Geller, Frank Aben, Katja KH Stacey, Simon N Gudmundsson, Julius Jakobsdottir, Margret Bergthorsson, Jon T Sigurdsson, Asgeir Blondal, Thorarinn Witjes, J Alfred Vermeulen, Sita H Hulsbergen-van de Kaa, Christina A Swinkels, Dorine W Ploeg, Martine Cornel, Erik B Vergunst, Henk Thorgeirsson, Thorgeir E Gudbjartsson, Daniel Gudjonsson, Sigurjon A Thorleifsson, Gudmar Kristinsson, Kari T Mouy, Magali Snorradottir, Steinunn Placidi, Donatella Campagna, Marcello Arici, Cecilia Koppova, Kvetoslava Gurzau, Eugene Rudnai, Peter Kellen, Eliane Polidoro, Silvia Guarrera, Simonetta Sacerdote, Carlotta Sanchez, Manuel Saez, Berta Valdivia, Gabriel Ryk, Charlotta de Verdier, Petra Lindblom, Annika Golka, Klaus Bishop, D Timothy Knowles, Margaret A Nikulasson, Sigfus Petursdottir, Vigdis Jonsson, Eirikur Geirsson, Gudmundur Kristjansson, Baldvin Mayordomo, Jose I Steineck, Gunnar Porru, Stefano Buntinx, Frank Zeegers, Maurice P Fletcher, Tony Kumar, Rajiv Matullo, Giuseppe Vineis, Paolo Kiltie, Anne E Gulcher, Jeffrey R Thorsteinsdottir, Unnur Kong, Augustine Rafnar, Thorunn Stefansson, Kari |
author_sort |
Kiemeney, Lambertus A |
title |
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer. |
title_short |
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer. |
title_full |
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer. |
title_fullStr |
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer. |
title_full_unstemmed |
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer. |
title_sort |
sequence variant on 8q24 confers susceptibility to urinary bladder cancer. |
publisher |
Nature Research |
publishDate |
2008 |
url |
https://researchonline.lshtm.ac.uk/id/eprint/6594/ |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
Kiemeney, Lambertus A; Thorlacius, Steinunn; Sulem, Patrick; Geller, Frank; Aben, Katja KH; Stacey, Simon N; Gudmundsson, Julius; Jakobsdottir, Margret; Bergthorsson, Jon T; Sigurdsson, Asgeir; +54 more. Blondal, Thorarinn; Witjes, J Alfred; Vermeulen, Sita H; Hulsbergen-van de Kaa, Christina A; Swinkels, Dorine W; Ploeg, Martine; Cornel, Erik B; Vergunst, Henk; Thorgeirsson, Thorgeir E; Gudbjartsson, Daniel; Gudjonsson, Sigurjon A; Thorleifsson, Gudmar; Kristinsson, Kari T; Mouy, Magali; Snorradottir, Steinunn; Placidi, Donatella; Campagna, Marcello; Arici, Cecilia; Koppova, Kvetoslava; Gurzau, Eugene; Rudnai, Peter; Kellen, Eliane; Polidoro, Silvia; Guarrera, Simonetta; Sacerdote, Carlotta; Sanchez, Manuel; Saez, Berta; Valdivia, Gabriel; Ryk, Charlotta; de Verdier, Petra; Lindblom, Annika; Golka, Klaus; Bishop, D Timothy; Knowles, Margaret A; Nikulasson, Sigfus; Petursdottir, Vigdis; Jonsson, Eirikur; Geirsson, Gudmundur; Kristjansson, Baldvin; Mayordomo, Jose I; Steineck, Gunnar; Porru, Stefano; Buntinx, Frank; Zeegers, Maurice P; Fletcher, Tony <https://researchonline.lshtm.ac.uk/view/creators/ppehtfle.html>; Kumar, Rajiv; Matullo, Giuseppe; Vineis, Paolo; Kiltie, Anne E; Gulcher, Jeffrey R; Thorsteinsdottir, Unnur; Kong, Augustine; Rafnar, Thorunn; Stefansson, Kari; (2008) Sequence variant on 8q24 confers susceptibility to urinary bladder cancer. Nature genetics, 40 (11). pp. 1307-1312. ISSN 1061-4036 DOI: https://doi.org/10.1038/ng.229 <https://doi.org/10.1038/ng.229> |
op_doi |
https://doi.org/10.1038/ng.229 |
container_title |
Nature Genetics |
container_volume |
40 |
container_issue |
11 |
container_start_page |
1307 |
op_container_end_page |
1312 |
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1766039572862468096 |