Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway.
BACKGROUND: Little data exists on the prevalence of chronic kidney disease (CKD) in the Russian population. We aimed to estimate the prevalence of CKD in a population-based study in Russia, compare with a similar study in Norway, and investigate whether differences in risk factors explained between-...
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Online Access: | https://researchonline.lshtm.ac.uk/id/eprint/4665276/ https://researchonline.lshtm.ac.uk/id/eprint/4665276/7/Cook_etal_2022_Comparing-prevalence-of-chronic-kidney.pdf |
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ftlshtm:oai:researchonline.lshtm.ac.uk:4665276 2024-06-23T07:50:59+00:00 Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway. Cook, Sarah Solbu, Marit D Eggen, Anne Elise Iakunchykova, Olena Averina, Maria Hopstock, Laila A Kholmatova, Kamila Kudryavtsev, Alexander V Leon, David A Malyutina, Sofia Ryabikov, Andrew Williamson, Elizabeth Nitsch, Dorothea 2022-04-14 text https://researchonline.lshtm.ac.uk/id/eprint/4665276/ https://researchonline.lshtm.ac.uk/id/eprint/4665276/7/Cook_etal_2022_Comparing-prevalence-of-chronic-kidney.pdf en eng BMC https://researchonline.lshtm.ac.uk/id/eprint/4665276/7/Cook_etal_2022_Comparing-prevalence-of-chronic-kidney.pdf Cook, Sarah <https://researchonline.lshtm.ac.uk/view/creators/ppehscoo.html>; Solbu, Marit D; Eggen, Anne Elise; Iakunchykova, Olena; Averina, Maria; Hopstock, Laila A; Kholmatova, Kamila; Kudryavtsev, Alexander V; Leon, David A <https://researchonline.lshtm.ac.uk/view/creators/encddleo.html>; Malyutina, Sofia; +3 more. Ryabikov, Andrew; Williamson, Elizabeth <https://researchonline.lshtm.ac.uk/view/creators/emsuewil.html>; Nitsch, Dorothea <https://researchonline.lshtm.ac.uk/view/creators/encddnit.html>; (2022) Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway. BMC Nephrology, 23 (1). 145-. ISSN 1471-2369 DOI: https://doi.org/10.1186/s12882-022-02738-2 <https://doi.org/10.1186/s12882-022-02738-2> cc_by_4 Article PeerReviewed 2022 ftlshtm https://doi.org/10.1186/s12882-022-02738-2 2024-06-04T14:21:40Z BACKGROUND: Little data exists on the prevalence of chronic kidney disease (CKD) in the Russian population. We aimed to estimate the prevalence of CKD in a population-based study in Russia, compare with a similar study in Norway, and investigate whether differences in risk factors explained between-study differences in CKD. METHODS: We compared age- and sex-standardised prevalence of reduced eGFR (< 60 ml/min/1.73m2 CKD-EPI creatinine equation), albuminuria and or a composite indicator of CKD (one measure of either reduced eGFR or albuminuria) between participants aged 40-69 in the population-based Know Your Heart (KYH) study, Russia (2015-2018 N = 4607) and the seventh Tromsø Study (Tromsø7), Norway (2015-2016 N = 17,646). We assessed the contribution of established CKD risk factors (low education, diabetes, hypertension, antihypertensive use, smoking, obesity) to between-study differences using logistic regression. RESULTS: Prevalence of reduced eGFR or albuminuria was 6.5% (95% Confidence Interval (CI) 5.4, 7.7) in KYH and 4.6% (95% CI 4.0, 5.2) in Tromsø7 standardised for sex and age. Odds of both clinical outcomes were higher in KYH than Tromsø7 (reduced eGFR OR 2.06 95% CI 1.67, 2.54; albuminuria OR 1.54 95% CI 1.16, 2.03) adjusted for sex and age. Risk factor adjustment explained the observed between-study difference in albuminuria (OR 0.92 95% CI 0.68, 1.25) but only partially reduced eGFR (OR 1.42 95% CI 1.11, 1.82). The strongest explanatory factors for the between-study difference was higher use of antihypertensives (Russian sample) for reduced eGFR and mean diastolic blood pressure for albuminuria. CONCLUSIONS: We found evidence of a higher burden of CKD within the sample from the population in Arkhangelsk and Novosibirsk compared to Tromsø, partly explained by between-study population differences in established risk factors. In particular hypertension defined by medication use was an important factor associated with the higher CKD prevalence in the Russian sample. Article in Journal/Newspaper Arkhangelsk Tromsø London School of Hygiene & Tropical Medicine: LSHTM Research Online Norway Tromsø BMC Nephrology 23 1 |
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London School of Hygiene & Tropical Medicine: LSHTM Research Online |
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language |
English |
description |
BACKGROUND: Little data exists on the prevalence of chronic kidney disease (CKD) in the Russian population. We aimed to estimate the prevalence of CKD in a population-based study in Russia, compare with a similar study in Norway, and investigate whether differences in risk factors explained between-study differences in CKD. METHODS: We compared age- and sex-standardised prevalence of reduced eGFR (< 60 ml/min/1.73m2 CKD-EPI creatinine equation), albuminuria and or a composite indicator of CKD (one measure of either reduced eGFR or albuminuria) between participants aged 40-69 in the population-based Know Your Heart (KYH) study, Russia (2015-2018 N = 4607) and the seventh Tromsø Study (Tromsø7), Norway (2015-2016 N = 17,646). We assessed the contribution of established CKD risk factors (low education, diabetes, hypertension, antihypertensive use, smoking, obesity) to between-study differences using logistic regression. RESULTS: Prevalence of reduced eGFR or albuminuria was 6.5% (95% Confidence Interval (CI) 5.4, 7.7) in KYH and 4.6% (95% CI 4.0, 5.2) in Tromsø7 standardised for sex and age. Odds of both clinical outcomes were higher in KYH than Tromsø7 (reduced eGFR OR 2.06 95% CI 1.67, 2.54; albuminuria OR 1.54 95% CI 1.16, 2.03) adjusted for sex and age. Risk factor adjustment explained the observed between-study difference in albuminuria (OR 0.92 95% CI 0.68, 1.25) but only partially reduced eGFR (OR 1.42 95% CI 1.11, 1.82). The strongest explanatory factors for the between-study difference was higher use of antihypertensives (Russian sample) for reduced eGFR and mean diastolic blood pressure for albuminuria. CONCLUSIONS: We found evidence of a higher burden of CKD within the sample from the population in Arkhangelsk and Novosibirsk compared to Tromsø, partly explained by between-study population differences in established risk factors. In particular hypertension defined by medication use was an important factor associated with the higher CKD prevalence in the Russian sample. |
format |
Article in Journal/Newspaper |
author |
Cook, Sarah Solbu, Marit D Eggen, Anne Elise Iakunchykova, Olena Averina, Maria Hopstock, Laila A Kholmatova, Kamila Kudryavtsev, Alexander V Leon, David A Malyutina, Sofia Ryabikov, Andrew Williamson, Elizabeth Nitsch, Dorothea |
spellingShingle |
Cook, Sarah Solbu, Marit D Eggen, Anne Elise Iakunchykova, Olena Averina, Maria Hopstock, Laila A Kholmatova, Kamila Kudryavtsev, Alexander V Leon, David A Malyutina, Sofia Ryabikov, Andrew Williamson, Elizabeth Nitsch, Dorothea Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway. |
author_facet |
Cook, Sarah Solbu, Marit D Eggen, Anne Elise Iakunchykova, Olena Averina, Maria Hopstock, Laila A Kholmatova, Kamila Kudryavtsev, Alexander V Leon, David A Malyutina, Sofia Ryabikov, Andrew Williamson, Elizabeth Nitsch, Dorothea |
author_sort |
Cook, Sarah |
title |
Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway. |
title_short |
Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway. |
title_full |
Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway. |
title_fullStr |
Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway. |
title_full_unstemmed |
Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway. |
title_sort |
comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in russia and norway. |
publisher |
BMC |
publishDate |
2022 |
url |
https://researchonline.lshtm.ac.uk/id/eprint/4665276/ https://researchonline.lshtm.ac.uk/id/eprint/4665276/7/Cook_etal_2022_Comparing-prevalence-of-chronic-kidney.pdf |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Arkhangelsk Tromsø |
genre_facet |
Arkhangelsk Tromsø |
op_relation |
https://researchonline.lshtm.ac.uk/id/eprint/4665276/7/Cook_etal_2022_Comparing-prevalence-of-chronic-kidney.pdf Cook, Sarah <https://researchonline.lshtm.ac.uk/view/creators/ppehscoo.html>; Solbu, Marit D; Eggen, Anne Elise; Iakunchykova, Olena; Averina, Maria; Hopstock, Laila A; Kholmatova, Kamila; Kudryavtsev, Alexander V; Leon, David A <https://researchonline.lshtm.ac.uk/view/creators/encddleo.html>; Malyutina, Sofia; +3 more. Ryabikov, Andrew; Williamson, Elizabeth <https://researchonline.lshtm.ac.uk/view/creators/emsuewil.html>; Nitsch, Dorothea <https://researchonline.lshtm.ac.uk/view/creators/encddnit.html>; (2022) Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway. BMC Nephrology, 23 (1). 145-. ISSN 1471-2369 DOI: https://doi.org/10.1186/s12882-022-02738-2 <https://doi.org/10.1186/s12882-022-02738-2> |
op_rights |
cc_by_4 |
op_doi |
https://doi.org/10.1186/s12882-022-02738-2 |
container_title |
BMC Nephrology |
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23 |
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1 |
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1802641963272372224 |