Variation in KSHV prevalence between geographically proximate locations in Uganda.
Kaposi's sarcoma-associated herpesvirus (KSHV) transmission within endemic areas may vary. KSHV seroprevalence has been studied by different groups of researchers using different methods, making it difficult to make direct comparisons. Here we show results on KSHV seroprevalence using the same...
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2020
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Online Access: | https://researchonline.lshtm.ac.uk/id/eprint/4657590/ https://researchonline.lshtm.ac.uk/id/eprint/4657590/1/Variation%20in%20KSHV%20prevalence%20between%20geographically%20proximate%20locations%20in%20Uganda.pdf |
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ftlshtm:oai:researchonline.lshtm.ac.uk:4657590 2024-06-09T07:50:06+00:00 Variation in KSHV prevalence between geographically proximate locations in Uganda. Nalwoga, Angela Webb, Emily L Muserere, Claudios Chihota, Belinda Miley, Wendell Labo, Nazzarena Elliott, Alison Cose, Stephen Whitby, Denise Newton, Robert 2020-01 text https://researchonline.lshtm.ac.uk/id/eprint/4657590/ https://researchonline.lshtm.ac.uk/id/eprint/4657590/1/Variation%20in%20KSHV%20prevalence%20between%20geographically%20proximate%20locations%20in%20Uganda.pdf en eng Springer Science and Business Media LLC https://researchonline.lshtm.ac.uk/id/eprint/4657590/1/Variation%20in%20KSHV%20prevalence%20between%20geographically%20proximate%20locations%20in%20Uganda.pdf Nalwoga, Angela; Webb, Emily L <https://researchonline.lshtm.ac.uk/view/creators/eideeweb.html>; Muserere, Claudios; Chihota, Belinda; Miley, Wendell; Labo, Nazzarena; Elliott, Alison <https://researchonline.lshtm.ac.uk/view/creators/icruaell.html>; Cose, Stephen <https://researchonline.lshtm.ac.uk/view/creators/icruscos.html>; Whitby, Denise; Newton, Robert <https://researchonline.lshtm.ac.uk/view/creators/lshrn2.html>; (2020) Variation in KSHV prevalence between geographically proximate locations in Uganda. Infectious agents and cancer, 15 (1). 49-. ISSN 1750-9378 DOI: https://doi.org/10.1186/s13027-020-00313-8 <https://doi.org/10.1186/s13027-020-00313-8> cc_by Article PeerReviewed 2020 ftlshtm https://doi.org/10.1186/s13027-020-00313-8 2024-05-15T00:06:24Z Kaposi's sarcoma-associated herpesvirus (KSHV) transmission within endemic areas may vary. KSHV seroprevalence has been studied by different groups of researchers using different methods, making it difficult to make direct comparisons. Here we show results on KSHV seroprevalence using the same laboratory method from four different but geographically proximate populations in Uganda. Blood samples from the urban Entebbe Mother and Baby Study (EMaBS), the rural General Population Cohort (GPC), the fishing community Lake Victoria Island Intervention Study on Worms and Allergy related Diseases (LaVIISWA) and the high-risk sexual behaviour Good Health for Women Project (GHWP), were tested for IgG antibody levels to K8.1 and ORF73 recombinant proteins using ELISA. All adult participants of the EMaBS study and the GHWP were women, while the GPC (54% female) and LaVIISWA (52% female) studies had both males and females. EMaBS children were all 5 years of age while their mothers were 14 to 47 years of age. GHWP women were 15 to 45 years old, LaVIISWA participants were 1 to 72 years old while GPC participants were 1 to 103 years old. KSHV seropositivity varied in the different populations. In children aged 5 years, EMaBS had the lowest prevalence of 15% followed by GPC at 35% and LaVIISWA at 54%. In adult women, seropositivity varied from 69% (EMaBS) to 80% (LaVIISWA) to 87% (GPC) to 90% (GHWP). The reasons for the variation in prevalence are unclear but may reflect differences in the prevalence of cofactors between these four geographically proximate populations. Article in Journal/Newspaper Victoria Island London School of Hygiene & Tropical Medicine: LSHTM Research Online Infectious Agents and Cancer 15 1 |
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London School of Hygiene & Tropical Medicine: LSHTM Research Online |
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English |
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Kaposi's sarcoma-associated herpesvirus (KSHV) transmission within endemic areas may vary. KSHV seroprevalence has been studied by different groups of researchers using different methods, making it difficult to make direct comparisons. Here we show results on KSHV seroprevalence using the same laboratory method from four different but geographically proximate populations in Uganda. Blood samples from the urban Entebbe Mother and Baby Study (EMaBS), the rural General Population Cohort (GPC), the fishing community Lake Victoria Island Intervention Study on Worms and Allergy related Diseases (LaVIISWA) and the high-risk sexual behaviour Good Health for Women Project (GHWP), were tested for IgG antibody levels to K8.1 and ORF73 recombinant proteins using ELISA. All adult participants of the EMaBS study and the GHWP were women, while the GPC (54% female) and LaVIISWA (52% female) studies had both males and females. EMaBS children were all 5 years of age while their mothers were 14 to 47 years of age. GHWP women were 15 to 45 years old, LaVIISWA participants were 1 to 72 years old while GPC participants were 1 to 103 years old. KSHV seropositivity varied in the different populations. In children aged 5 years, EMaBS had the lowest prevalence of 15% followed by GPC at 35% and LaVIISWA at 54%. In adult women, seropositivity varied from 69% (EMaBS) to 80% (LaVIISWA) to 87% (GPC) to 90% (GHWP). The reasons for the variation in prevalence are unclear but may reflect differences in the prevalence of cofactors between these four geographically proximate populations. |
format |
Article in Journal/Newspaper |
author |
Nalwoga, Angela Webb, Emily L Muserere, Claudios Chihota, Belinda Miley, Wendell Labo, Nazzarena Elliott, Alison Cose, Stephen Whitby, Denise Newton, Robert |
spellingShingle |
Nalwoga, Angela Webb, Emily L Muserere, Claudios Chihota, Belinda Miley, Wendell Labo, Nazzarena Elliott, Alison Cose, Stephen Whitby, Denise Newton, Robert Variation in KSHV prevalence between geographically proximate locations in Uganda. |
author_facet |
Nalwoga, Angela Webb, Emily L Muserere, Claudios Chihota, Belinda Miley, Wendell Labo, Nazzarena Elliott, Alison Cose, Stephen Whitby, Denise Newton, Robert |
author_sort |
Nalwoga, Angela |
title |
Variation in KSHV prevalence between geographically proximate locations in Uganda. |
title_short |
Variation in KSHV prevalence between geographically proximate locations in Uganda. |
title_full |
Variation in KSHV prevalence between geographically proximate locations in Uganda. |
title_fullStr |
Variation in KSHV prevalence between geographically proximate locations in Uganda. |
title_full_unstemmed |
Variation in KSHV prevalence between geographically proximate locations in Uganda. |
title_sort |
variation in kshv prevalence between geographically proximate locations in uganda. |
publisher |
Springer Science and Business Media LLC |
publishDate |
2020 |
url |
https://researchonline.lshtm.ac.uk/id/eprint/4657590/ https://researchonline.lshtm.ac.uk/id/eprint/4657590/1/Variation%20in%20KSHV%20prevalence%20between%20geographically%20proximate%20locations%20in%20Uganda.pdf |
genre |
Victoria Island |
genre_facet |
Victoria Island |
op_relation |
https://researchonline.lshtm.ac.uk/id/eprint/4657590/1/Variation%20in%20KSHV%20prevalence%20between%20geographically%20proximate%20locations%20in%20Uganda.pdf Nalwoga, Angela; Webb, Emily L <https://researchonline.lshtm.ac.uk/view/creators/eideeweb.html>; Muserere, Claudios; Chihota, Belinda; Miley, Wendell; Labo, Nazzarena; Elliott, Alison <https://researchonline.lshtm.ac.uk/view/creators/icruaell.html>; Cose, Stephen <https://researchonline.lshtm.ac.uk/view/creators/icruscos.html>; Whitby, Denise; Newton, Robert <https://researchonline.lshtm.ac.uk/view/creators/lshrn2.html>; (2020) Variation in KSHV prevalence between geographically proximate locations in Uganda. Infectious agents and cancer, 15 (1). 49-. ISSN 1750-9378 DOI: https://doi.org/10.1186/s13027-020-00313-8 <https://doi.org/10.1186/s13027-020-00313-8> |
op_rights |
cc_by |
op_doi |
https://doi.org/10.1186/s13027-020-00313-8 |
container_title |
Infectious Agents and Cancer |
container_volume |
15 |
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1 |
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1801383259490222080 |