Relation of immediate postnatal growth with obesity and related metabolic risk factors in adulthood: the northern Finland birth cohort 1966 study.
The authors examined associations between postnatal growth velocity through age 2 years and metabolic outcomes at age 31 years in a population-based birth-cohort study of 3,778 Finns (1966-1998). Approximately 8 height measurements and 9 weight measurements were obtained from birth to age 2 years. P...
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ftlshtm:oai:researchonline.lshtm.ac.uk:3579 2023-05-15T17:42:39+02:00 Relation of immediate postnatal growth with obesity and related metabolic risk factors in adulthood: the northern Finland birth cohort 1966 study. Tzoulaki, Ioanna Sovio, Ulla Pillas, Demetris Hartikainen, Anna-Liisa Pouta, Anneli Laitinen, Jaana Tammelin, Tuija H Jarvelin, Marjo-Riitta Elliott, Paul 2010 https://researchonline.lshtm.ac.uk/id/eprint/3579/ unknown Oxford University Press (OUP) Tzoulaki, Ioanna; Sovio, Ulla; Pillas, Demetris; Hartikainen, Anna-Liisa; Pouta, Anneli; Laitinen, Jaana; Tammelin, Tuija H; Jarvelin, Marjo-Riitta; Elliott, Paul; (2010) Relation of immediate postnatal growth with obesity and related metabolic risk factors in adulthood: the northern Finland birth cohort 1966 study. American journal of epidemiology, 171 (9). pp. 989-998. ISSN 0002-9262 DOI: https://doi.org/10.1093/aje/kwq027 <https://doi.org/10.1093/aje/kwq027> Article PeerReviewed 2010 ftlshtm https://doi.org/10.1093/aje/kwq027 2022-03-03T06:36:36Z The authors examined associations between postnatal growth velocity through age 2 years and metabolic outcomes at age 31 years in a population-based birth-cohort study of 3,778 Finns (1966-1998). Approximately 8 height measurements and 9 weight measurements were obtained from birth to age 2 years. Peak height velocity (PHV) and peak weight velocity (PWV) in infancy were derived from parametric growth curves fitted to longitudinal height and weight growth data. Body mass index (BMI), waist circumference (WC), high density lipoprotein (HDL) cholesterol, triglycerides, glucose, systolic and diastolic blood pressure (BP), and the metabolic syndrome were measured at age 31 years. PHV was significantly positively associated with systolic and diastolic BP and WC in adulthood. For each 8-cm/year (2-standard-deviation) increase in PHV, WC increased by 1.60 cm (95% confidence interval: 0.73, 2.46), after adjustment for potential confounders, including birth weight. PWV was significantly associated with adulthood systolic BP, WC, and BMI. A 4-kg/year higher PWV was associated with a 1.87-cm (95% confidence interval: 1.08, 2.65) larger WC in adulthood, after adjustment for potential confounders. HDL cholesterol (direct), triglycerides (inverse), and metabolic syndrome (inverse) displayed associations with PWV only after BMI was accounted for. These results showed that growth during the immediate postnatal period is associated with adulthood obesity and BP. Lifestyle changes from early life might be important in reducing adulthood obesity and high-BP risk. Article in Journal/Newspaper Northern Finland London School of Hygiene & Tropical Medicine: LSHTM Research Online American Journal of Epidemiology 171 9 989 998 |
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London School of Hygiene & Tropical Medicine: LSHTM Research Online |
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The authors examined associations between postnatal growth velocity through age 2 years and metabolic outcomes at age 31 years in a population-based birth-cohort study of 3,778 Finns (1966-1998). Approximately 8 height measurements and 9 weight measurements were obtained from birth to age 2 years. Peak height velocity (PHV) and peak weight velocity (PWV) in infancy were derived from parametric growth curves fitted to longitudinal height and weight growth data. Body mass index (BMI), waist circumference (WC), high density lipoprotein (HDL) cholesterol, triglycerides, glucose, systolic and diastolic blood pressure (BP), and the metabolic syndrome were measured at age 31 years. PHV was significantly positively associated with systolic and diastolic BP and WC in adulthood. For each 8-cm/year (2-standard-deviation) increase in PHV, WC increased by 1.60 cm (95% confidence interval: 0.73, 2.46), after adjustment for potential confounders, including birth weight. PWV was significantly associated with adulthood systolic BP, WC, and BMI. A 4-kg/year higher PWV was associated with a 1.87-cm (95% confidence interval: 1.08, 2.65) larger WC in adulthood, after adjustment for potential confounders. HDL cholesterol (direct), triglycerides (inverse), and metabolic syndrome (inverse) displayed associations with PWV only after BMI was accounted for. These results showed that growth during the immediate postnatal period is associated with adulthood obesity and BP. Lifestyle changes from early life might be important in reducing adulthood obesity and high-BP risk. |
format |
Article in Journal/Newspaper |
author |
Tzoulaki, Ioanna Sovio, Ulla Pillas, Demetris Hartikainen, Anna-Liisa Pouta, Anneli Laitinen, Jaana Tammelin, Tuija H Jarvelin, Marjo-Riitta Elliott, Paul |
spellingShingle |
Tzoulaki, Ioanna Sovio, Ulla Pillas, Demetris Hartikainen, Anna-Liisa Pouta, Anneli Laitinen, Jaana Tammelin, Tuija H Jarvelin, Marjo-Riitta Elliott, Paul Relation of immediate postnatal growth with obesity and related metabolic risk factors in adulthood: the northern Finland birth cohort 1966 study. |
author_facet |
Tzoulaki, Ioanna Sovio, Ulla Pillas, Demetris Hartikainen, Anna-Liisa Pouta, Anneli Laitinen, Jaana Tammelin, Tuija H Jarvelin, Marjo-Riitta Elliott, Paul |
author_sort |
Tzoulaki, Ioanna |
title |
Relation of immediate postnatal growth with obesity and related metabolic risk factors in adulthood: the northern Finland birth cohort 1966 study. |
title_short |
Relation of immediate postnatal growth with obesity and related metabolic risk factors in adulthood: the northern Finland birth cohort 1966 study. |
title_full |
Relation of immediate postnatal growth with obesity and related metabolic risk factors in adulthood: the northern Finland birth cohort 1966 study. |
title_fullStr |
Relation of immediate postnatal growth with obesity and related metabolic risk factors in adulthood: the northern Finland birth cohort 1966 study. |
title_full_unstemmed |
Relation of immediate postnatal growth with obesity and related metabolic risk factors in adulthood: the northern Finland birth cohort 1966 study. |
title_sort |
relation of immediate postnatal growth with obesity and related metabolic risk factors in adulthood: the northern finland birth cohort 1966 study. |
publisher |
Oxford University Press (OUP) |
publishDate |
2010 |
url |
https://researchonline.lshtm.ac.uk/id/eprint/3579/ |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
Tzoulaki, Ioanna; Sovio, Ulla; Pillas, Demetris; Hartikainen, Anna-Liisa; Pouta, Anneli; Laitinen, Jaana; Tammelin, Tuija H; Jarvelin, Marjo-Riitta; Elliott, Paul; (2010) Relation of immediate postnatal growth with obesity and related metabolic risk factors in adulthood: the northern Finland birth cohort 1966 study. American journal of epidemiology, 171 (9). pp. 989-998. ISSN 0002-9262 DOI: https://doi.org/10.1093/aje/kwq027 <https://doi.org/10.1093/aje/kwq027> |
op_doi |
https://doi.org/10.1093/aje/kwq027 |
container_title |
American Journal of Epidemiology |
container_volume |
171 |
container_issue |
9 |
container_start_page |
989 |
op_container_end_page |
998 |
_version_ |
1766144538262372352 |