Variation in survival of children with central nervous system (CNS) malignancies diagnosed in Europe between 1978 and 1992: the EUROCARE study.
EUROCARE is a population-based survival study including data from European Cancer Registries. The present paper analyses survival after a malignant neoplasm of the central nervous system (CNS) in childhood (aged 0--14 years at diagnosis). The database includes 6130 cases from 34 population-based reg...
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ftlshtm:oai:researchonline.lshtm.ac.uk:18114 2023-05-15T16:52:58+02:00 Variation in survival of children with central nervous system (CNS) malignancies diagnosed in Europe between 1978 and 1992: the EUROCARE study. Magnani, C Aareleid, T Viscomi, S Pastore, G Berrino, F EUROCARE Working Group 2001 https://researchonline.lshtm.ac.uk/id/eprint/18114/ unknown Elsevier Magnani, C; Aareleid, T; Viscomi, S; Pastore, G; Berrino, F; EUROCARE Working Group; (2001) Variation in survival of children with central nervous system (CNS) malignancies diagnosed in Europe between 1978 and 1992: the EUROCARE study. European journal of cancer (Oxford, England, 37 (6). pp. 711-721. ISSN 0959-8049 DOI: https://doi.org/10.1016/s0959-8049(01)00046-6 <https://doi.org/10.1016/s0959-8049(01)00046-6> Article PeerReviewed 2001 ftlshtm https://doi.org/10.1016/s0959-8049(01)00046-6 2022-03-03T06:51:51Z EUROCARE is a population-based survival study including data from European Cancer Registries. The present paper analyses survival after a malignant neoplasm of the central nervous system (CNS) in childhood (aged 0--14 years at diagnosis). The database includes 6130 cases from 34 population-based registries in 17 countries: 1558 were primitive neuroectodermal tumours (PNET) and 4087 astrocytoma, ependymoma or other gliomas: these morphologies were grouped in the analyses in order to reduce the diagnostic variability among the registries. 87% of cases were microscopically diagnosed (range among registries 71--100%) and losses to follow-up were limited to 2% (range 0--14%). Actuarial analyses indicate that the European (weighted) average of 5 years cumulative survival for cases diagnosed in 1978--1989 was 53% (95% confidence interval (CI) 49--57) for CNS neoplasms, 44% (95% CI 37--50) for PNET and 60% (95% CI 55--65) for the glioma-related types. Analysis of the sub-set of cases diagnosed in 1985--1989 revealed better results: cumulative survival at 5 years was 61% (95% CI: 55--65) for all CNS neoplasms; 48% (95% CI 41--56) for PNET and 68% (95% CI 62--73) for glioma-related types. Compared with older children, infants showed poorer prognosis: in 1978--1989 the 5-year survival rate was 33% (95% CI 23--45) and in 1985--1989 it was 46% (95% CI 34--59). Variability among countries was very large, with 5-year survival for CNS tumours diagnosed in 1985--1989 ranging from 28% in Estonia (95% CI 17--43) to 73% Sweden (95% CI 59--83) and 75% in Iceland (95% CI 35--95) and 73% in Finland (95% CI 66--79). Time trends were studied in a multivariate analysis observing a reduction in the risk of death in periods of diagnosis 1982--1985 (hazard ratio (HR)=0.85; 95% CI 0.78--0.93) and 1986--1989 (HR=0.70; 95% CI 0.64--0.77) compared with 1978--1981. The analysis were extended to 1990--1992 for the countries whose registries provided data for that period did not indicate any further progress. Results of this study confirm the large variability in European countries and indicate a positive trend in the survival probability for cases diagnosed in the 1980s. Article in Journal/Newspaper Iceland London School of Hygiene & Tropical Medicine: LSHTM Research Online European Journal of Cancer 37 6 711 721 |
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London School of Hygiene & Tropical Medicine: LSHTM Research Online |
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description |
EUROCARE is a population-based survival study including data from European Cancer Registries. The present paper analyses survival after a malignant neoplasm of the central nervous system (CNS) in childhood (aged 0--14 years at diagnosis). The database includes 6130 cases from 34 population-based registries in 17 countries: 1558 were primitive neuroectodermal tumours (PNET) and 4087 astrocytoma, ependymoma or other gliomas: these morphologies were grouped in the analyses in order to reduce the diagnostic variability among the registries. 87% of cases were microscopically diagnosed (range among registries 71--100%) and losses to follow-up were limited to 2% (range 0--14%). Actuarial analyses indicate that the European (weighted) average of 5 years cumulative survival for cases diagnosed in 1978--1989 was 53% (95% confidence interval (CI) 49--57) for CNS neoplasms, 44% (95% CI 37--50) for PNET and 60% (95% CI 55--65) for the glioma-related types. Analysis of the sub-set of cases diagnosed in 1985--1989 revealed better results: cumulative survival at 5 years was 61% (95% CI: 55--65) for all CNS neoplasms; 48% (95% CI 41--56) for PNET and 68% (95% CI 62--73) for glioma-related types. Compared with older children, infants showed poorer prognosis: in 1978--1989 the 5-year survival rate was 33% (95% CI 23--45) and in 1985--1989 it was 46% (95% CI 34--59). Variability among countries was very large, with 5-year survival for CNS tumours diagnosed in 1985--1989 ranging from 28% in Estonia (95% CI 17--43) to 73% Sweden (95% CI 59--83) and 75% in Iceland (95% CI 35--95) and 73% in Finland (95% CI 66--79). Time trends were studied in a multivariate analysis observing a reduction in the risk of death in periods of diagnosis 1982--1985 (hazard ratio (HR)=0.85; 95% CI 0.78--0.93) and 1986--1989 (HR=0.70; 95% CI 0.64--0.77) compared with 1978--1981. The analysis were extended to 1990--1992 for the countries whose registries provided data for that period did not indicate any further progress. Results of this study confirm the large variability in European countries and indicate a positive trend in the survival probability for cases diagnosed in the 1980s. |
format |
Article in Journal/Newspaper |
author |
Magnani, C Aareleid, T Viscomi, S Pastore, G Berrino, F EUROCARE Working Group |
spellingShingle |
Magnani, C Aareleid, T Viscomi, S Pastore, G Berrino, F EUROCARE Working Group Variation in survival of children with central nervous system (CNS) malignancies diagnosed in Europe between 1978 and 1992: the EUROCARE study. |
author_facet |
Magnani, C Aareleid, T Viscomi, S Pastore, G Berrino, F EUROCARE Working Group |
author_sort |
Magnani, C |
title |
Variation in survival of children with central nervous system (CNS) malignancies diagnosed in Europe between 1978 and 1992: the EUROCARE study. |
title_short |
Variation in survival of children with central nervous system (CNS) malignancies diagnosed in Europe between 1978 and 1992: the EUROCARE study. |
title_full |
Variation in survival of children with central nervous system (CNS) malignancies diagnosed in Europe between 1978 and 1992: the EUROCARE study. |
title_fullStr |
Variation in survival of children with central nervous system (CNS) malignancies diagnosed in Europe between 1978 and 1992: the EUROCARE study. |
title_full_unstemmed |
Variation in survival of children with central nervous system (CNS) malignancies diagnosed in Europe between 1978 and 1992: the EUROCARE study. |
title_sort |
variation in survival of children with central nervous system (cns) malignancies diagnosed in europe between 1978 and 1992: the eurocare study. |
publisher |
Elsevier |
publishDate |
2001 |
url |
https://researchonline.lshtm.ac.uk/id/eprint/18114/ |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
Magnani, C; Aareleid, T; Viscomi, S; Pastore, G; Berrino, F; EUROCARE Working Group; (2001) Variation in survival of children with central nervous system (CNS) malignancies diagnosed in Europe between 1978 and 1992: the EUROCARE study. European journal of cancer (Oxford, England, 37 (6). pp. 711-721. ISSN 0959-8049 DOI: https://doi.org/10.1016/s0959-8049(01)00046-6 <https://doi.org/10.1016/s0959-8049(01)00046-6> |
op_doi |
https://doi.org/10.1016/s0959-8049(01)00046-6 |
container_title |
European Journal of Cancer |
container_volume |
37 |
container_issue |
6 |
container_start_page |
711 |
op_container_end_page |
721 |
_version_ |
1766043481143246848 |