Galactose-alpha-1,3-galactose Specific IgE is Associated with Anaphylaxis but not Asthma.
RATIONALE: IgE antibodies to the mammalian oligosaccharide galactose-alpha-1,3-galactose (alpha-gal) are common in the southeastern United States. These antibodies, which are induced by ectoparasitic ticks, can give rise to positive skin tests or serum assays with cat extract. OBJECTIVE: To evaluate...
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American Thoracic Society
2012
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ftliverpoolstm:oai:archive.lstmed.ac.uk:2802 2023-05-15T17:44:55+02:00 Galactose-alpha-1,3-galactose Specific IgE is Associated with Anaphylaxis but not Asthma. Commins, Scott P Kelly, Libby A Rönmark, Eva James, Hayley R Pochan, Shawna L Peters, Edward J Lundbäck, Bo Nganga, Lucy W Cooper, Phil Hoskins, Janelle M Eapen, Saju S Matos, Luis A McBride, Dane C Heymann, Peter W Woodfolk, Judith A Perzanowski, Matthew S Platts-Mills, Thomas A E 2012-04-01 https://archive.lstmed.ac.uk/2802/ http://ajrccm.atsjournals.org/content/185/7/723.abstract en eng American Thoracic Society Commins, Scott P, Kelly, Libby A, Rönmark, Eva, James, Hayley R, Pochan, Shawna L, Peters, Edward J, Lundbäck, Bo, Nganga, Lucy W, Cooper, Phil, Hoskins, Janelle M, Eapen, Saju S, Matos, Luis A, McBride, Dane C, Heymann, Peter W, Woodfolk, Judith A, Perzanowski, Matthew S and Platts-Mills, Thomas A E (2012) 'Galactose-alpha-1,3-galactose Specific IgE is Associated with Anaphylaxis but not Asthma.'. American Journal of Respiratory and Critical Care Medicine, Vol 185, Issue 7, pp. 723-730. American Journal of Respiratory and Critical Care Medicine, Vol 185, Issue 7, pp. 723-730. QW 900 Anaphylaxis and hypersensitivity. Allergens WF 140 Diseases of the respiratory system (General) Article PeerReviewed 2012 ftliverpoolstm 2023-01-30T21:21:13Z RATIONALE: IgE antibodies to the mammalian oligosaccharide galactose-alpha-1,3-galactose (alpha-gal) are common in the southeastern United States. These antibodies, which are induced by ectoparasitic ticks, can give rise to positive skin tests or serum assays with cat extract. OBJECTIVE: To evaluate the relationship between IgE antibodies to alpha-gal and asthma, and compare this with the relationship between asthma and IgE antibodies to Fel d 1 and other protein allergens. METHODS: Patients being investigated for recurrent anaphylaxis, angioedema, or acute urticaria underwent spirometry, exhaled nitric oxide (eNO), questionnaires, and serum IgE antibody assays. The results were compared with control subjects as well as cohorts from the Emergency Department (ED) in Virginia (n=130), northern Sweden (n=963), and rural Kenya (n=131). MEASUREMENTS AND MAIN RESULTS: Patients in Virginia with high titer IgE antibodies to alpha-gal had normal lung function, low levels of eNO, and low prevalence of asthma symptoms. Among patients in the ED and children in Kenya, there was no association between IgE antibodies to alpha-gal and asthma (odds ratios 1.04 and 0.75, respectively). In Sweden, IgE antibodies to cat were closely correlated with IgE antibodies to Fel d 1 (r=0.83), and to asthma (p<0.001). CONCLUSIONS: These results provide: i) a model of an ectoparasite-induced specific IgE response that can increase total serum IgE without creating a risk for asthma, and ii) further evidence that the main allergens that are causally related to asthma are those that are inhaled. Article in Journal/Newspaper Northern Sweden LSTM Online Archive (Liverpool School of Tropical Medicine) |
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LSTM Online Archive (Liverpool School of Tropical Medicine) |
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English |
topic |
QW 900 Anaphylaxis and hypersensitivity. Allergens WF 140 Diseases of the respiratory system (General) |
spellingShingle |
QW 900 Anaphylaxis and hypersensitivity. Allergens WF 140 Diseases of the respiratory system (General) Commins, Scott P Kelly, Libby A Rönmark, Eva James, Hayley R Pochan, Shawna L Peters, Edward J Lundbäck, Bo Nganga, Lucy W Cooper, Phil Hoskins, Janelle M Eapen, Saju S Matos, Luis A McBride, Dane C Heymann, Peter W Woodfolk, Judith A Perzanowski, Matthew S Platts-Mills, Thomas A E Galactose-alpha-1,3-galactose Specific IgE is Associated with Anaphylaxis but not Asthma. |
topic_facet |
QW 900 Anaphylaxis and hypersensitivity. Allergens WF 140 Diseases of the respiratory system (General) |
description |
RATIONALE: IgE antibodies to the mammalian oligosaccharide galactose-alpha-1,3-galactose (alpha-gal) are common in the southeastern United States. These antibodies, which are induced by ectoparasitic ticks, can give rise to positive skin tests or serum assays with cat extract. OBJECTIVE: To evaluate the relationship between IgE antibodies to alpha-gal and asthma, and compare this with the relationship between asthma and IgE antibodies to Fel d 1 and other protein allergens. METHODS: Patients being investigated for recurrent anaphylaxis, angioedema, or acute urticaria underwent spirometry, exhaled nitric oxide (eNO), questionnaires, and serum IgE antibody assays. The results were compared with control subjects as well as cohorts from the Emergency Department (ED) in Virginia (n=130), northern Sweden (n=963), and rural Kenya (n=131). MEASUREMENTS AND MAIN RESULTS: Patients in Virginia with high titer IgE antibodies to alpha-gal had normal lung function, low levels of eNO, and low prevalence of asthma symptoms. Among patients in the ED and children in Kenya, there was no association between IgE antibodies to alpha-gal and asthma (odds ratios 1.04 and 0.75, respectively). In Sweden, IgE antibodies to cat were closely correlated with IgE antibodies to Fel d 1 (r=0.83), and to asthma (p<0.001). CONCLUSIONS: These results provide: i) a model of an ectoparasite-induced specific IgE response that can increase total serum IgE without creating a risk for asthma, and ii) further evidence that the main allergens that are causally related to asthma are those that are inhaled. |
format |
Article in Journal/Newspaper |
author |
Commins, Scott P Kelly, Libby A Rönmark, Eva James, Hayley R Pochan, Shawna L Peters, Edward J Lundbäck, Bo Nganga, Lucy W Cooper, Phil Hoskins, Janelle M Eapen, Saju S Matos, Luis A McBride, Dane C Heymann, Peter W Woodfolk, Judith A Perzanowski, Matthew S Platts-Mills, Thomas A E |
author_facet |
Commins, Scott P Kelly, Libby A Rönmark, Eva James, Hayley R Pochan, Shawna L Peters, Edward J Lundbäck, Bo Nganga, Lucy W Cooper, Phil Hoskins, Janelle M Eapen, Saju S Matos, Luis A McBride, Dane C Heymann, Peter W Woodfolk, Judith A Perzanowski, Matthew S Platts-Mills, Thomas A E |
author_sort |
Commins, Scott P |
title |
Galactose-alpha-1,3-galactose Specific IgE is Associated with Anaphylaxis but not Asthma. |
title_short |
Galactose-alpha-1,3-galactose Specific IgE is Associated with Anaphylaxis but not Asthma. |
title_full |
Galactose-alpha-1,3-galactose Specific IgE is Associated with Anaphylaxis but not Asthma. |
title_fullStr |
Galactose-alpha-1,3-galactose Specific IgE is Associated with Anaphylaxis but not Asthma. |
title_full_unstemmed |
Galactose-alpha-1,3-galactose Specific IgE is Associated with Anaphylaxis but not Asthma. |
title_sort |
galactose-alpha-1,3-galactose specific ige is associated with anaphylaxis but not asthma. |
publisher |
American Thoracic Society |
publishDate |
2012 |
url |
https://archive.lstmed.ac.uk/2802/ http://ajrccm.atsjournals.org/content/185/7/723.abstract |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
American Journal of Respiratory and Critical Care Medicine, Vol 185, Issue 7, pp. 723-730. |
op_relation |
Commins, Scott P, Kelly, Libby A, Rönmark, Eva, James, Hayley R, Pochan, Shawna L, Peters, Edward J, Lundbäck, Bo, Nganga, Lucy W, Cooper, Phil, Hoskins, Janelle M, Eapen, Saju S, Matos, Luis A, McBride, Dane C, Heymann, Peter W, Woodfolk, Judith A, Perzanowski, Matthew S and Platts-Mills, Thomas A E (2012) 'Galactose-alpha-1,3-galactose Specific IgE is Associated with Anaphylaxis but not Asthma.'. American Journal of Respiratory and Critical Care Medicine, Vol 185, Issue 7, pp. 723-730. |
_version_ |
1766147215373369344 |