DNA-thioguanine nucleotide concentration and relapse-free survival during maintenance therapy of childhood acute lymphoblastic leukaemia (NOPHO ALL2008): a prospective substudy of a phase 3 trial

• Published in: The Lancet Oncology
• Main Authors: Nielsen, Stine Nygaard, Grell, Kathrine, Nersting, Jacob, Abrahamsson, Jonas, Lund, Bendik, Kanerva, Jukka, Jónsson, Ólafur Gísli, Vaitkevičienė, Goda Elizabeta, Pruunsild, Kaie, Hjalgrim, Lisa Lyngsie, Schmiegelow, Kjeld
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2017
• Subjects: systemic exposure; risk; children; methotrexate; thiopurines; mercaptopurine; 6-thioguanine; pharmacokinetics; 6-mercaptopurine; intensification; Christensen; Norway; Iceland
• Online Access: http://vu.lvb.lt/VU:ELABAPDB49405954&prefLang=en_US

BACKGROUND: Adjustment of mercaptopurine and methotrexate maintenance therapy of acute lymphoblastic leukaemia by leucocyte count is confounded by natural variations. Cytotoxicity is primarily mediated by DNA-incorporated thioguanine nucleotides (DNA-TGN). The aim of this study was to establish whet...