Kiwifruit allergy across Europe: Clinical manifestation and IgE recognition patterns to kiwifruit allergens
Background: Kiwifruit is a common cause of food allergy. Symptoms range from mild to anaphylactic reactions. Objective: We sought to elucidate geographic differences across Europe regarding clinical patterns and sensitization to kiwifruit allergens. Factors associated with the severity of kiwifruit...
Published in: | Journal of Allergy and Clinical Immunology |
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ftlitinstagrecon:oai:elaba:4642056 2023-05-15T16:47:32+02:00 Kiwifruit allergy across Europe: Clinical manifestation and IgE recognition patterns to kiwifruit allergens Le, Thuy-Me. Bublin, Merima. Breiteneder, Heimo. Fernandez-Rivas, Montserrat Asero, Riccardo Ballmer-Weber, Barbara Barreales, Laura Bures, Peter Belohlavkova, Simona de Blay, Frederic Clausen, M. Dubakienė, Rūta Gislason, David van Hoffen, Els Jedrzejczak-Czechowicz, Monika. Kowalski, Marek Kralimarkova, Tanya Lidholm, Jonas DeWitt, Asa Marknell Mills, ClareE.N. Papadopoulos, Nikos G. Popov, Todor Purohit, Ashok van Ree, Ronald Seneviratne, Suranjith. Sinaniotis, Athanasios Summers, Colin Vázquez-Cortés, Sonia Vieths, Stefan Vogel, Lothar. Hoffmann-Sommergruber, Karin Knulst, Andre C. 2013 http://vu.lvb.lt/VU:ELABAPDB4642056&prefLang=en_US eng eng info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jaci.2012.09.009 http://vu.lvb.lt/VU:ELABAPDB4642056&prefLang=en_US Journal of allergy and clinical immunology, Milwaukee : Mosby, Inc, 2013, vol. 131, no. 1, p. 164-171 ISSN 0091-6749 Actinidin Allergens Component resolved diagnosis Food allergy ImmunoCAP Kiwifruit Skin prick test info:eu-repo/semantics/article 2013 ftlitinstagrecon https://doi.org/10.1016/j.jaci.2012.09.009 2021-12-02T01:15:01Z Background: Kiwifruit is a common cause of food allergy. Symptoms range from mild to anaphylactic reactions. Objective: We sought to elucidate geographic differences across Europe regarding clinical patterns and sensitization to kiwifruit allergens. Factors associated with the severity of kiwifruit allergy were identified, and the diagnostic performance of specific kiwifruit allergens was investigated. Methods: This study was part of EuroPrevall, a multicenter European study investigating several aspects of food allergy. Three hundred eleven patients with kiwifruit allergy from 12 countries representing 4 climatic regions were included. Specific IgE to 6 allergens (Act d 1, Act d 2, Act d 5, Act d 8, Act d 9, and Act d 10) and kiwifruit extract were tested by using ImmunoCAP. Results: Patients from Iceland were mainly sensitized to Act d 1 (32%), those from western/central and eastern Europe were mainly sensitized to Act d 8 (pathogenesis-related class 10 protein, 58% and 44%, respectively), and those from southern Europe were mainly sensitized to Act d 9 (profilin, 31%) and Act d 10 (nonspecific lipid transfer protein, 22%). Sensitization to Act d 1 and living in Iceland were independently and significantly associated with severe kiwifruit allergy (odds ratio, 3.98 [P 5 .003] and 5.60 [P < .001], respectively). Using a panel of 6 kiwifruit allergens in ImmunoCAP increased the diagnostic sensitivity to 65% compared with 20% for skin prick tests and 46% ImmunoCAP using kiwi extract. Conclusion: Kiwifruit allergen sensitization patterns differ across Europe. The use of specific kiwifruit allergens improved the diagnostic performance compared with kiwifruit extract. Sensitization to Act d 1 and living in Iceland are strong risk factors for severe kiwifruit allergy. Article in Journal/Newspaper Iceland LAEI VL (Lithuanian Institute of Agrarian Economics Virtual Library) Journal of Allergy and Clinical Immunology 131 1 164 171 |
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Open Polar |
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LAEI VL (Lithuanian Institute of Agrarian Economics Virtual Library) |
op_collection_id |
ftlitinstagrecon |
language |
English |
topic |
Actinidin Allergens Component resolved diagnosis Food allergy ImmunoCAP Kiwifruit Skin prick test |
spellingShingle |
Actinidin Allergens Component resolved diagnosis Food allergy ImmunoCAP Kiwifruit Skin prick test Le, Thuy-Me. Bublin, Merima. Breiteneder, Heimo. Fernandez-Rivas, Montserrat Asero, Riccardo Ballmer-Weber, Barbara Barreales, Laura Bures, Peter Belohlavkova, Simona de Blay, Frederic Clausen, M. Dubakienė, Rūta Gislason, David van Hoffen, Els Jedrzejczak-Czechowicz, Monika. Kowalski, Marek Kralimarkova, Tanya Lidholm, Jonas DeWitt, Asa Marknell Mills, ClareE.N. Papadopoulos, Nikos G. Popov, Todor Purohit, Ashok van Ree, Ronald Seneviratne, Suranjith. Sinaniotis, Athanasios Summers, Colin Vázquez-Cortés, Sonia Vieths, Stefan Vogel, Lothar. Hoffmann-Sommergruber, Karin Knulst, Andre C. Kiwifruit allergy across Europe: Clinical manifestation and IgE recognition patterns to kiwifruit allergens |
topic_facet |
Actinidin Allergens Component resolved diagnosis Food allergy ImmunoCAP Kiwifruit Skin prick test |
description |
Background: Kiwifruit is a common cause of food allergy. Symptoms range from mild to anaphylactic reactions. Objective: We sought to elucidate geographic differences across Europe regarding clinical patterns and sensitization to kiwifruit allergens. Factors associated with the severity of kiwifruit allergy were identified, and the diagnostic performance of specific kiwifruit allergens was investigated. Methods: This study was part of EuroPrevall, a multicenter European study investigating several aspects of food allergy. Three hundred eleven patients with kiwifruit allergy from 12 countries representing 4 climatic regions were included. Specific IgE to 6 allergens (Act d 1, Act d 2, Act d 5, Act d 8, Act d 9, and Act d 10) and kiwifruit extract were tested by using ImmunoCAP. Results: Patients from Iceland were mainly sensitized to Act d 1 (32%), those from western/central and eastern Europe were mainly sensitized to Act d 8 (pathogenesis-related class 10 protein, 58% and 44%, respectively), and those from southern Europe were mainly sensitized to Act d 9 (profilin, 31%) and Act d 10 (nonspecific lipid transfer protein, 22%). Sensitization to Act d 1 and living in Iceland were independently and significantly associated with severe kiwifruit allergy (odds ratio, 3.98 [P 5 .003] and 5.60 [P < .001], respectively). Using a panel of 6 kiwifruit allergens in ImmunoCAP increased the diagnostic sensitivity to 65% compared with 20% for skin prick tests and 46% ImmunoCAP using kiwi extract. Conclusion: Kiwifruit allergen sensitization patterns differ across Europe. The use of specific kiwifruit allergens improved the diagnostic performance compared with kiwifruit extract. Sensitization to Act d 1 and living in Iceland are strong risk factors for severe kiwifruit allergy. |
format |
Article in Journal/Newspaper |
author |
Le, Thuy-Me. Bublin, Merima. Breiteneder, Heimo. Fernandez-Rivas, Montserrat Asero, Riccardo Ballmer-Weber, Barbara Barreales, Laura Bures, Peter Belohlavkova, Simona de Blay, Frederic Clausen, M. Dubakienė, Rūta Gislason, David van Hoffen, Els Jedrzejczak-Czechowicz, Monika. Kowalski, Marek Kralimarkova, Tanya Lidholm, Jonas DeWitt, Asa Marknell Mills, ClareE.N. Papadopoulos, Nikos G. Popov, Todor Purohit, Ashok van Ree, Ronald Seneviratne, Suranjith. Sinaniotis, Athanasios Summers, Colin Vázquez-Cortés, Sonia Vieths, Stefan Vogel, Lothar. Hoffmann-Sommergruber, Karin Knulst, Andre C. |
author_facet |
Le, Thuy-Me. Bublin, Merima. Breiteneder, Heimo. Fernandez-Rivas, Montserrat Asero, Riccardo Ballmer-Weber, Barbara Barreales, Laura Bures, Peter Belohlavkova, Simona de Blay, Frederic Clausen, M. Dubakienė, Rūta Gislason, David van Hoffen, Els Jedrzejczak-Czechowicz, Monika. Kowalski, Marek Kralimarkova, Tanya Lidholm, Jonas DeWitt, Asa Marknell Mills, ClareE.N. Papadopoulos, Nikos G. Popov, Todor Purohit, Ashok van Ree, Ronald Seneviratne, Suranjith. Sinaniotis, Athanasios Summers, Colin Vázquez-Cortés, Sonia Vieths, Stefan Vogel, Lothar. Hoffmann-Sommergruber, Karin Knulst, Andre C. |
author_sort |
Le, Thuy-Me. |
title |
Kiwifruit allergy across Europe: Clinical manifestation and IgE recognition patterns to kiwifruit allergens |
title_short |
Kiwifruit allergy across Europe: Clinical manifestation and IgE recognition patterns to kiwifruit allergens |
title_full |
Kiwifruit allergy across Europe: Clinical manifestation and IgE recognition patterns to kiwifruit allergens |
title_fullStr |
Kiwifruit allergy across Europe: Clinical manifestation and IgE recognition patterns to kiwifruit allergens |
title_full_unstemmed |
Kiwifruit allergy across Europe: Clinical manifestation and IgE recognition patterns to kiwifruit allergens |
title_sort |
kiwifruit allergy across europe: clinical manifestation and ige recognition patterns to kiwifruit allergens |
publishDate |
2013 |
url |
http://vu.lvb.lt/VU:ELABAPDB4642056&prefLang=en_US |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Journal of allergy and clinical immunology, Milwaukee : Mosby, Inc, 2013, vol. 131, no. 1, p. 164-171 ISSN 0091-6749 |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jaci.2012.09.009 http://vu.lvb.lt/VU:ELABAPDB4642056&prefLang=en_US |
op_doi |
https://doi.org/10.1016/j.jaci.2012.09.009 |
container_title |
Journal of Allergy and Clinical Immunology |
container_volume |
131 |
container_issue |
1 |
container_start_page |
164 |
op_container_end_page |
171 |
_version_ |
1766037630367039488 |