Development and validation of the UHPLC method with using of the monolithic column for quantitative determination of famotidine in tablets
Introduction. High performance, expresness due to the using a column lenght of 10 cm and a particle size up to 2 microns are the advantages of the UHPLC method, that allows to prefer this method in the routine quality control in comparison with the others. Monolithic columns just started to find the...
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ftlitinstagrecon:oai:elaba:23296432 2023-05-15T17:14:00+02:00 Development and validation of the UHPLC method with using of the monolithic column for quantitative determination of famotidine in tablets Myhal, Artem Marksa, Mindaugas Golovchenko, Olga Gubar, Svitlana Georgiyants, Victoriya Ivanauskas, Liudas 2017 http://lsmu.lvb.lt/LSMU:ELABAPDB23296432&prefLang=en_US eng eng http://lsmu.lvb.lt/LSMU:ELABAPDB23296432&prefLang=en_US 20th anniversary of BaltPharm Forum (BPhF 2017) : April 28-30, 2017 Jūrmala, Latvia : abstracts / Pharmacists’ Society of Latvia (PSL), Jūrmala : Pharmacists’ Society of Latvia, 2017, p. 17-17 Famotidine administration&dosage analysis Tablets Chromatography high pressure liquid methods info:eu-repo/classification/udc/615.074 info:eu-repo/semantics/conferencePaper 2017 ftlitinstagrecon 2021-12-02T01:05:39Z Introduction. High performance, expresness due to the using a column lenght of 10 cm and a particle size up to 2 microns are the advantages of the UHPLC method, that allows to prefer this method in the routine quality control in comparison with the others. Monolithic columns just started to find their application in the pharmaceutical analysis. Their peculiarity that the porous sorbtion layer is symthesized directly in the column. The sorbtion layer has the biporous structure: transport macropores with the practical size of 1.8-2 microns and mesopores with the partical size of 11-12 nm, where the substances separation is taking place. The aim of the work was to develop a simple method forį the quantitative determination of famotidine in the tablets by UHPLC method with using monolitic column that would reduce the time of analysis, reduce using of toxic reagents and volumes of solvents. Methods and materials. The famotidine tablets, containing 20 mg of active substance (Arterium Corporation, Ukraine), and famotidine substance (Nakoda Chemicals Ild, India) were chosen as objects of study. The sample solutions and the standart solution were prepared in concentration of 0.1 mg/mL. [.]. Conference Object Nakoda LAEI VL (Lithuanian Institute of Agrarian Economics Virtual Library) |
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LAEI VL (Lithuanian Institute of Agrarian Economics Virtual Library) |
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ftlitinstagrecon |
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English |
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Famotidine administration&dosage analysis Tablets Chromatography high pressure liquid methods info:eu-repo/classification/udc/615.074 |
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Famotidine administration&dosage analysis Tablets Chromatography high pressure liquid methods info:eu-repo/classification/udc/615.074 Myhal, Artem Marksa, Mindaugas Golovchenko, Olga Gubar, Svitlana Georgiyants, Victoriya Ivanauskas, Liudas Development and validation of the UHPLC method with using of the monolithic column for quantitative determination of famotidine in tablets |
topic_facet |
Famotidine administration&dosage analysis Tablets Chromatography high pressure liquid methods info:eu-repo/classification/udc/615.074 |
description |
Introduction. High performance, expresness due to the using a column lenght of 10 cm and a particle size up to 2 microns are the advantages of the UHPLC method, that allows to prefer this method in the routine quality control in comparison with the others. Monolithic columns just started to find their application in the pharmaceutical analysis. Their peculiarity that the porous sorbtion layer is symthesized directly in the column. The sorbtion layer has the biporous structure: transport macropores with the practical size of 1.8-2 microns and mesopores with the partical size of 11-12 nm, where the substances separation is taking place. The aim of the work was to develop a simple method forį the quantitative determination of famotidine in the tablets by UHPLC method with using monolitic column that would reduce the time of analysis, reduce using of toxic reagents and volumes of solvents. Methods and materials. The famotidine tablets, containing 20 mg of active substance (Arterium Corporation, Ukraine), and famotidine substance (Nakoda Chemicals Ild, India) were chosen as objects of study. The sample solutions and the standart solution were prepared in concentration of 0.1 mg/mL. [.]. |
format |
Conference Object |
author |
Myhal, Artem Marksa, Mindaugas Golovchenko, Olga Gubar, Svitlana Georgiyants, Victoriya Ivanauskas, Liudas |
author_facet |
Myhal, Artem Marksa, Mindaugas Golovchenko, Olga Gubar, Svitlana Georgiyants, Victoriya Ivanauskas, Liudas |
author_sort |
Myhal, Artem |
title |
Development and validation of the UHPLC method with using of the monolithic column for quantitative determination of famotidine in tablets |
title_short |
Development and validation of the UHPLC method with using of the monolithic column for quantitative determination of famotidine in tablets |
title_full |
Development and validation of the UHPLC method with using of the monolithic column for quantitative determination of famotidine in tablets |
title_fullStr |
Development and validation of the UHPLC method with using of the monolithic column for quantitative determination of famotidine in tablets |
title_full_unstemmed |
Development and validation of the UHPLC method with using of the monolithic column for quantitative determination of famotidine in tablets |
title_sort |
development and validation of the uhplc method with using of the monolithic column for quantitative determination of famotidine in tablets |
publishDate |
2017 |
url |
http://lsmu.lvb.lt/LSMU:ELABAPDB23296432&prefLang=en_US |
genre |
Nakoda |
genre_facet |
Nakoda |
op_source |
20th anniversary of BaltPharm Forum (BPhF 2017) : April 28-30, 2017 Jūrmala, Latvia : abstracts / Pharmacists’ Society of Latvia (PSL), Jūrmala : Pharmacists’ Society of Latvia, 2017, p. 17-17 |
op_relation |
http://lsmu.lvb.lt/LSMU:ELABAPDB23296432&prefLang=en_US |
_version_ |
1766071246604206080 |