CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis

• Published in: Annals of the Rheumatic Diseases
• Main Authors: Kastbom, Alf, Johansson, Martin, Verma, Deepti, Söderkvist, Peter, Rantapaa-Dahlqvist, Solbritt
• Format: Article in Journal/Newspaper
• Language: English
• Published: Reumatologi 2010
• Subjects: Medical and Health Sciences; Medicin och hälsovetenskap; Verma; Northern Sweden
• Online Access: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-54719; https://doi.org/10.1136/ard.2008.106989

Objectives CARD8 and NLRP3 are constituents of the inflammasome which regulates interleukin 1 beta production. The influence of polymorphisms in CARD8 and NLRP3 on rheumatoid arthritis (RA) susceptibility and severity were evaluated. Methods CARD8 p.C10X and NLRP3 p.Q705K genotypes were assessed in...