CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis
Objectives CARD8 and NLRP3 are constituents of the inflammasome which regulates interleukin 1 beta production. The influence of polymorphisms in CARD8 and NLRP3 on rheumatoid arthritis (RA) susceptibility and severity were evaluated. Methods CARD8 p.C10X and NLRP3 p.Q705K genotypes were assessed in...
Published in: | Annals of the Rheumatic Diseases |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Reumatologi
2010
|
Subjects: | |
Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-54719 https://doi.org/10.1136/ard.2008.106989 |
id |
ftlinkoepinguniv:oai:DiVA.org:liu-54719 |
---|---|
record_format |
openpolar |
spelling |
ftlinkoepinguniv:oai:DiVA.org:liu-54719 2023-05-15T17:44:46+02:00 CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis Kastbom, Alf Johansson, Martin Verma, Deepti Söderkvist, Peter Rantapaa-Dahlqvist, Solbritt 2010 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-54719 https://doi.org/10.1136/ard.2008.106989 eng eng Reumatologi Hälsouniversitetet Länskliniken för Reumatologi i Östergötland Cellbiologi Umeå University ANNALS OF THE RHEUMATIC DISEASES, 0003-4967, 2010, 69:4, s. 723-726 orcid:0000-0001-7187-1477 orcid:0000-0002-7415-2782 orcid:0000-0001-9867-8706 http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-54719 doi:10.1136/ard.2008.106989 ISI:000275723800019 info:eu-repo/semantics/openAccess Medical and Health Sciences Medicin och hälsovetenskap Article in journal info:eu-repo/semantics/article text 2010 ftlinkoepinguniv https://doi.org/10.1136/ard.2008.106989 2022-05-01T08:24:56Z Objectives CARD8 and NLRP3 are constituents of the inflammasome which regulates interleukin 1 beta production. The influence of polymorphisms in CARD8 and NLRP3 on rheumatoid arthritis (RA) susceptibility and severity were evaluated. Methods CARD8 p.C10X and NLRP3 p.Q705K genotypes were assessed in andgt;500 controls and patients with early RA from northern Sweden. The patients were monitored regularly over a 2-year period. The 28-joint disease activity score (DAS28) and its separate components were compared across genotypes. Results Patients with one or more variant alleles in CARD8 (CARD8-X) had increased DAS28, tender joint count and erythrocyte sedimentation rate during the 2-year follow-up period despite receiving disease-modifying antirheumatic drugs to a greater extent. CARD8-X was significantly over-represented among patients who received anti-tumour necrosis factor therapy during the first 2 years. CARD8 and NLRP3 genotypes did not influence radiological joint damage and were not associated with an increased susceptibility. Conclusions Carriage of CARD8-X is associated with a worse disease course in early RA. Original Publication:Alf Kastbom, Martin Johansson, Deepti Verma, Peter Söderkvist and Solbritt Rantapaa-Dahlqvist, CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis, 2010, ANNALS OF THE RHEUMATIC DISEASES, (69), 4, 723-726.http://dx.doi.org/10.1136/ard.2008.106989Copyright: BMJ Publishing Grouphttp://group.bmj.com/ Article in Journal/Newspaper Northern Sweden LIU - Linköping University: Publications (DiVA) Verma ENVELOPE(8.897,8.897,62.618,62.618) Annals of the Rheumatic Diseases 69 4 723 726 |
institution |
Open Polar |
collection |
LIU - Linköping University: Publications (DiVA) |
op_collection_id |
ftlinkoepinguniv |
language |
English |
topic |
Medical and Health Sciences Medicin och hälsovetenskap |
spellingShingle |
Medical and Health Sciences Medicin och hälsovetenskap Kastbom, Alf Johansson, Martin Verma, Deepti Söderkvist, Peter Rantapaa-Dahlqvist, Solbritt CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis |
topic_facet |
Medical and Health Sciences Medicin och hälsovetenskap |
description |
Objectives CARD8 and NLRP3 are constituents of the inflammasome which regulates interleukin 1 beta production. The influence of polymorphisms in CARD8 and NLRP3 on rheumatoid arthritis (RA) susceptibility and severity were evaluated. Methods CARD8 p.C10X and NLRP3 p.Q705K genotypes were assessed in andgt;500 controls and patients with early RA from northern Sweden. The patients were monitored regularly over a 2-year period. The 28-joint disease activity score (DAS28) and its separate components were compared across genotypes. Results Patients with one or more variant alleles in CARD8 (CARD8-X) had increased DAS28, tender joint count and erythrocyte sedimentation rate during the 2-year follow-up period despite receiving disease-modifying antirheumatic drugs to a greater extent. CARD8-X was significantly over-represented among patients who received anti-tumour necrosis factor therapy during the first 2 years. CARD8 and NLRP3 genotypes did not influence radiological joint damage and were not associated with an increased susceptibility. Conclusions Carriage of CARD8-X is associated with a worse disease course in early RA. Original Publication:Alf Kastbom, Martin Johansson, Deepti Verma, Peter Söderkvist and Solbritt Rantapaa-Dahlqvist, CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis, 2010, ANNALS OF THE RHEUMATIC DISEASES, (69), 4, 723-726.http://dx.doi.org/10.1136/ard.2008.106989Copyright: BMJ Publishing Grouphttp://group.bmj.com/ |
format |
Article in Journal/Newspaper |
author |
Kastbom, Alf Johansson, Martin Verma, Deepti Söderkvist, Peter Rantapaa-Dahlqvist, Solbritt |
author_facet |
Kastbom, Alf Johansson, Martin Verma, Deepti Söderkvist, Peter Rantapaa-Dahlqvist, Solbritt |
author_sort |
Kastbom, Alf |
title |
CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis |
title_short |
CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis |
title_full |
CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis |
title_fullStr |
CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis |
title_full_unstemmed |
CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis |
title_sort |
card8 p.c10x polymorphism is associated with inflammatory activity in early rheumatoid arthritis |
publisher |
Reumatologi |
publishDate |
2010 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-54719 https://doi.org/10.1136/ard.2008.106989 |
long_lat |
ENVELOPE(8.897,8.897,62.618,62.618) |
geographic |
Verma |
geographic_facet |
Verma |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
ANNALS OF THE RHEUMATIC DISEASES, 0003-4967, 2010, 69:4, s. 723-726 orcid:0000-0001-7187-1477 orcid:0000-0002-7415-2782 orcid:0000-0001-9867-8706 http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-54719 doi:10.1136/ard.2008.106989 ISI:000275723800019 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1136/ard.2008.106989 |
container_title |
Annals of the Rheumatic Diseases |
container_volume |
69 |
container_issue |
4 |
container_start_page |
723 |
op_container_end_page |
726 |
_version_ |
1766147044505812992 |