CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis

• Published in: Annals of the Rheumatic Diseases
• Main Authors: Kastbom, Alf, Johansson, Martin, Verma, Deepti, Söderkvist, Peter, Rantapaa-Dahlqvist, Solbritt
• Format: Article in Journal/Newspaper
• Language: English
• Published: Reumatologi 2010
• Subjects: Medical and Health Sciences; Medicin och hälsovetenskap; Verma; Northern Sweden
• Online Access: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-54719; https://doi.org/10.1136/ard.2008.106989

Objectives CARD8 and NLRP3 are constituents of the inflammasome which regulates interleukin 1 beta production. The influence of polymorphisms in CARD8 and NLRP3 on rheumatoid arthritis (RA) susceptibility and severity were evaluated. Methods CARD8 p.C10X and NLRP3 p.Q705K genotypes were assessed in andgt;500 controls and patients with early RA from northern Sweden. The patients were monitored regularly over a 2-year period. The 28-joint disease activity score (DAS28) and its separate components were compared across genotypes. Results Patients with one or more variant alleles in CARD8 (CARD8-X) had increased DAS28, tender joint count and erythrocyte sedimentation rate during the 2-year follow-up period despite receiving disease-modifying antirheumatic drugs to a greater extent. CARD8-X was significantly over-represented among patients who received anti-tumour necrosis factor therapy during the first 2 years. CARD8 and NLRP3 genotypes did not influence radiological joint damage and were not associated with an increased susceptibility. Conclusions Carriage of CARD8-X is associated with a worse disease course in early RA. Original Publication:Alf Kastbom, Martin Johansson, Deepti Verma, Peter Söderkvist and Solbritt Rantapaa-Dahlqvist, CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis, 2010, ANNALS OF THE RHEUMATIC DISEASES, (69), 4, 723-726.http://dx.doi.org/10.1136/ard.2008.106989Copyright: BMJ Publishing Grouphttp://group.bmj.com/